Search
Search Results
-
The Sensitivity of Multipotent Mesenchymal Stromal Cells to Short-Term Hypoxic Stress In Vitro Depends on the Efficiency of Homotypic Communication through Gap Junctions
AbstractGap junctions (GJ) provide metabolic cooperation between cells through the direct exchange of cytoplasmic components. The authors analyzed...
-
Homotypical Regulation of the Functional Activity of Multipotent Mesenchymal Stromal Cells: The Role of Gap Junctions
AbstractPerivascular multipotent mesenchymal stromal cells (MSCs) are considered as most likely putative depot for MSCs’ mobilization in the case of...
-
The Role of Gap Junctions in Endothelial–Stromal Cell Interactions
AbstractGap junctions are one of the most highly specialized intercellular communications providing not only electrical coupling but also metabolic...
-
Tight Junctions and Signaling Pathways in Cancer
Tight junctions (TJs) are intercellular connections that close the gap between the individual cells and limit the paracellular entry of harmful...
-
Molecular Architecture and Function of Tight Junctions
Tight junctions, also called zonula occludens, are supramolecular cell–cell adhesion complexes crucial for the architecture of epithelial tissues and...
-
Structure and Functions of Gap Junctions and Their Constituent Connexins in the Mammalian CNS
Abstract —Numerous data obtained in the last 20 years indicate that all parts of the mature central nervous system, from the retina and olfactory bulb...
-
Robo4 inhibits gamma radiation-induced permeability of a murine microvascular endothelial cell by regulating the junctions
BackgroundHematopoietic stem cell transplantation involves irradiation preconditioning which causes bone marrow endothelial cell dysfunction. While...
-
Oligomeric CHMP7 mediates three-way ER junctions and ER-mitochondria interactions
In metazoans the endoplasmic reticulum (ER) undergoes extensive remodeling during the cell cycle. The endosomal sorting complexes required for...
-
Cellular junction dynamics and Alzheimer’s disease: a comprehensive review
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by progressive neuronal damage and cognitive decline. Recent studies...
-
Ceramide/protein phosphatase 2A axis is engaged in gap junction impairment elicited by PCB153 in liver stem-like progenitor cells
The widespread environmental pollutant 2,2′,4,4′,5,5′-hexachlorobiphenyl (PCB153) is a non-dioxin-like toxicant. It is a potential carcinogen...
-
Regulation of Vascular Endothelial Barrier Integrity and Function by Lipid-Derived Mediators
Increased vascular permeability is a cardinal feature of acute lung injury and restoration of the disrupted endothelial barrier function is a...
-
Co-culture Techniques
Co-culturing cells in in vitro tissue models is a common technique for investigating how they interact. These models have been used to simulate a...
-
Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications
Gap junctions consist of arrays of intercellular channels that enable adjacent cells to communicate both electrically and metabolically. Gap...
-
Non-tight Junction Functions of Claudin Proteins: Roles in Cell-Matrix Interactions and Stem Cell Regulations
Tight junctions (TJs) are the most apical components of the junctional complex in epithelial cells, and they play an essential role in maintaining...
-
Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets
Recent studies reported that pancreatic β-cells are heterogeneous in terms of their transcriptional profiles and their abilities for insulin...
-
Chemical and Voltage Gating of Gap Junction Channels Expressed in Xenopus Oocytes
In most tissues, cells in contact with each other directly intercommunicate via cell-to-cell channels aggregated at gap junctions. Direct...
-
Interactomic exploration of LRRC8A in volume-regulated anion channels
Ion channels are critical in enabling ion movement into and within cells and are important targets for pharmacological interventions in different...
-
Trophoblast Syncytialization: A Metabolic Crossroads
During placentation, villous cytotrophoblast (CTB) stem cells proliferate and fuse, giving rise to the multinucleated syncytiotrophoblast (STB),...
-
Mechanisms and significance of entosis for tumour growth and progression
To date, numerous mechanisms have been identified in which one cell engulfs another, resulting in the creation of ‘cell-in-cell’ (CIC) structures,...
-
Structural Features of Neuro-Glio-Vascular Ensembles in the Glomeruli of the Rat Olfactory Bulb
AbstractThe glomeruli of the olfactory bulb of mammals are the primary coding elements of olfactory information. The excitation pattern produced by...
