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Gap Junctions in Ctenophora
Gap junction proteins form specialized intercellular communication channels, including electrical synapses, that regulate cellular metabolism and...
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The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation
Intercellular communication via gap junctions has a fundamental role in regulating cell growth and tissue homeostasis, and its dysregulation may be...
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Interplay between paclitaxel, gap junctions, and kinases: unraveling mechanisms of action and resistance in cancer therapy
This comprehensive review elucidates the multifaceted roles of paclitaxel, a key chemotherapeutic agent, in cancer therapy, with a focus on its...
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The Effect of Pronase on Mollusk, Leech, and Frog Nerve Ganglia Causes the Formation of Neuron–Neuronal Gap Junctions
Abstract—Using electron microscopy, the effect of pronase on nerve ganglia of a mollusk, leech, and frog was studied for the first time. It was...
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Homotypical Regulation of the Functional Activity of Multipotent Mesenchymal Stromal Cells: The Role of Gap Junctions
AbstractPerivascular multipotent mesenchymal stromal cells (MSCs) are considered as most likely putative depot for MSCs’ mobilization in the case of...
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The roles of connexins and gap junctions in the progression of cancer
Gap junctions (GJs), which are composed of connexins (Cxs), provide channels for direct information exchange between cells. Cx expression has a...
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The Sensitivity of Multipotent Mesenchymal Stromal Cells to Short-Term Hypoxic Stress In Vitro Depends on the Efficiency of Homotypic Communication through Gap Junctions
AbstractGap junctions (GJ) provide metabolic cooperation between cells through the direct exchange of cytoplasmic components. The authors analyzed...
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Downregulation of connexin 43-based gap junctions underlies propofol-induced excessive relaxation in hypertensive vascular smooth muscle cells
BackgroundPostinduction hypotension caused by propofol remains a non-negligible problem for anesthesiologists, and is especially severe in chronic...
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Confocal Laser and Electron Microscopic Investigation of Gap Junctions in Anaplastic Astrocytomas
Connexin 43 (Cx43)Connexin 43 (Cx43) is a multifunction protein that forms gap junction channels and hemichannels and is suggested to play an...
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The Role of Gap Junctions in Endothelial–Stromal Cell Interactions
AbstractGap junctions are one of the most highly specialized intercellular communications providing not only electrical coupling but also metabolic...
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The impact of Lactobacillus and Bifidobacterium probiotic cocktail on modulation of gene expression of gap junctions dysregulated by intestinal pathogens
Probiotics are special bacterial strains with strain specific impacts. They can affect health condition in intestine by producing organic acid,...
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Tight Junctions and Signaling Pathways in Cancer
Tight junctions (TJs) are intercellular connections that close the gap between the individual cells and limit the paracellular entry of harmful...
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Tight Junctions, Epithelial-Mesenchymal Transition, and Cancer Metastasis
Epithelial-mesenchymal transition (EMT) induces dynamic changes in the cellular organization leading to functional changes in cell migration,...
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Robo4 inhibits gamma radiation-induced permeability of a murine microvascular endothelial cell by regulating the junctions
BackgroundHematopoietic stem cell transplantation involves irradiation preconditioning which causes bone marrow endothelial cell dysfunction. While...
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Molecular Architecture and Function of Tight Junctions
Tight junctions, also called zonula occludens, are supramolecular cell–cell adhesion complexes crucial for the architecture of epithelial tissues and...
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LncRNA5251 inhibits spermatogenesis via modification of cell-cell junctions
BackgroundMale factors-caused decline in total fertility has raised significant concern worldwide. LncRNAs have been identified to play various roles...
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Structure and Functions of Gap Junctions and Their Constituent Connexins in the Mammalian CNS
Abstract —Numerous data obtained in the last 20 years indicate that all parts of the mature central nervous system, from the retina and olfactory bulb...
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Graphene–molecule–graphene single-molecule junctions to detect electronic reactions at the molecular scale
The ability to measure the behavior of a single molecule during a reaction implies the detection of inherent dynamic and static disordered states,...
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Plakophilin 4 controls the spatio-temporal activity of RhoA at adherens junctions to promote cortical actin ring formation and tissue tension
Plakophilin 4 (PKP4) is a component of cell–cell junctions that regulates intercellular adhesion and Rho-signaling during cytokinesis with an unknown...
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Imaging Techniques to Study Tight Junctions
Tight junctions (TJs) are important regulators of paracellular permeability that act as protective barriers against pathogens and maintain cell...