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Pathogenetic Mechanisms of Mental Disorders: Endogenous Intoxication
AbstractThe review describes the syndrome of endogenous intoxication in patients with mental disorders. Oxidative stress, middle-mass endotoxic...
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Glutamine Defended the Kidneys Versus Lead Intoxication Via Elevating Endogenous Antioxidants, Reducing Inflammation and Carbonyl Stress, as well as Improving Insulin Resistance and Dyslipidemia
Kidneys are primarily sensitive to lead (Pb) poisoning due to their cardinal role in lead excretion. Then, we studied the effect of glutamine (Gln)...
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Postmortem metabolomics: influence of time since death on the level of endogenous compounds in human femoral blood. Necessary to be considered in metabolome study planning?
IntroductionThe (un)targeted analysis of endogenous compounds has gained interest in the field of forensic postmortem investigations. The blood...
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Ergot Alkaloid and Endogenous Hormones Quantities and Relationship in Epichloë Endophyte: Drunken Horse Grass are Affected by Altitude
Achnatherum inebrians is rich in alkaloids (ergonovine and ergine) with analgesic activities and insect resistance activities and prevents animal...
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Protective Effect of Echinops persicus Extract on Oxidative Stress Enzymes in Various Rat Tissues after Carbon Tetrachloride Intoxication
AbstractMedicinal plants have been proposed as potential therapeutic agents for the treatment and prevention of various oxidative stress-related...
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Markers of Endogenous Intoxication in Late-Pregnancy Cows as Predictors of Pneumonia in Newborn Calves
AbstractEndogenous intoxication indices in late-pregnancy cows have been analyzed. The possibility for the use of these indices as predictors of...
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Zinc Oxide Nanoparticles Attenuated Neurochemical and Histopathological Alterations Associated with Aluminium Chloride Intoxication in Rats
The present investigation explored the potential neuroprotective role of zinc oxide nanoparticles (ZnONPs) on aluminum chloride (AlCl 3 )-mediated...
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Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication
Carbon monoxide (CO) is a gaseous molecule known as the silent killer. It is widely believed that an increase in blood carboxyhemoglobin (CO-Hb) is...
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Neuronal haemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein
Parkinson’s disease (PD) presents the selective loss of A9 dopaminergic (DA) neurons of Substantia Nigra pars compacta (SNpc) and the presence of...
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Ultrastructural Changes in the Kidneys and Biochemical Parameters of Blood and Urine in Rats under Acute Intoxication with O,O-Diethyl O-(4-nitrophenyl) Phosphate
AbstractPesticides based on organophosphorus compounds (OPCs) are widely used in agriculture worldwide, which is fraught with acute and chronic human...
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Quantification of 11 metabolites in rat urine after exposure to organophosphates
BackgroundThe aim of the study was to develop a technique for quantitative determination of rat urine metabolites by HPLC–MS/MS, which can be used to...
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Natural intoxication caused by protodioscin in lambs kept in Brachiaria pastures
Protodioscin poisoning of Brachiaria spp. has been a serious problem for lambs in grazing systems. The defoliation process can stimulate the...
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Anti-intoxication and protective effects of a recombinant serine protease inhibitor from Lentinula edodes against acute alcohol-induced liver injury in mice
Serine protease inhibitors (serpins) are involved in inflammation, coagulation, fibrinolysis, tumor suppression, molecular chaperone, chromatin...
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Perindopril Dampens Cd-induced Nephrotoxicity by Suppressing Inflammatory Burden, Ang II/Ang 1–7, and Apoptosis Signaling Pathways
Cadmium (Cd) is one of the most abundant toxic heavy metals, and its exposure is linked to serious kidney intoxication, a major health problem....
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Prognostic Value of Hematological and Biochemical Parameters of Mother and Newborn Calf for Bronchopneumonia Risk Assessment in Neonatal Calves
AbstractSurveys were carried out in order to analyze the markers of endogenous intoxication; the hematological, mineral, and hormonal status of the...
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Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern Humans
Timelines of population-level effects of viruses on humans varied from the evolutionary scale of million years to contemporary spread of viral...
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Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1–7 Signals
Cadmium (Cd) is a serious pollutant in the environment. Candesartan is an angiotensin II (Ang II) receptor antagonist with promising diverse health...
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Hepatoprotective Effect of Nicotinamide Versus Lead-Motivated Hepatotoxicity in Rats via Correcting Effect on Nuclear Factor-kβ Pathway and Glutathione Metabolism
Lead (Pb) poisoning is one of the pivotal environmental issues and prompts liver dysfunction by elevating oxidative stress and inflammation....
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N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations
N -Acetyl-L-cysteine (NAC) is an endogenous cysteine metabolite. The drug is widely used in chronic obstructive pulmonary disease (COPD) and as...
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A soybean based-diet prevents Cadmium access to rat cerebellum, maintaining trace elements homeostasis and avoiding morphological alterations
Cadmium (Cd) is one of the most dangerous heavy metals that exists. A prolonged exposure to Cd causes toxic effects in a variety of tissues,...
