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Reproductive Carrier Screening
People carry varying burden of genetic diseases, like recessive disorders. Therefore, the disease alleles they carry and their potential to pass them...
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Challenges in Reproductive Carrier Screening
Carrier screening is a process that aims to identify carrier individuals who may inherit disease-causing alleles to their future generations. Due to...
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Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease
Alzheimer’s disease (AD) is a chronic illness marked by increasing cognitive decline and nervous system deterioration. At this time, there is no...
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Defined Engineered Human Myocardium for Disease Modeling , Drug Screening, and Heart Repair
Different engineered heart muscle formats have been developed for applications in disease modeling, drug screening, and heart repair. The advantage...
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High-throughput virtual screening of potential inhibitors of GPR52 using docking and biased sampling method for Huntington’s disease therapy
Huntington’s disease (HD) is a rare and progressive neurodegenerative disorder caused by polyglutamine (poly-Q) mutations of the huntingtin ( HTT )...
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Identification of potential JNK3 inhibitors through virtual screening, molecular docking and molecular dynamics simulation as therapeutics for Alzheimer’s disease
Alzheimer’s disease (AD) is a complex neurological disorder and no effective drug is available for its treatment. Numerous pathological conditions...
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An efficient screening system of disease-resistant genes from wild apple, Malus sieversii in response to Valsa mali pathogenic fungus
For molecular breeding of future apples, wild apple ( Malus sieversii ), the primary progenitor of domesticated apples, provides abundant genetic...
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Tissue-Engineered 3D In Vitro Disease Models for High-Throughput Drug Screening
During high-throughput drug screening, in vitro models are fabricated and the effects of therapeutics on the models evaluated in high throughput—for...
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Occurrence of passion fruit woodiness disease in the coastal lowlands of Kenya and screening of passion fruit genotypes for resistance to passion fruit woodiness disease
BackgroundPassion fruit ( Passiflora edulis [Sims]) is an important economic fruit crop in Kenya, grown for domestic, regional and international...
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Ethical Solicitude in Reproductive Carrier Screening
The reproductive carrier screening that helps people know their own carrier status sometimes prevents an individual from having children or take...
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Identification of novel potential cathepsin-B inhibitors through pharmacophore-based virtual screening, molecular docking, and dynamics simulation studies for the treatment of Alzheimer’s disease
Cathepsin B is a cysteine protease lysosomal enzyme involved in several physiological functions. Overexpression of the enzyme enhances its...
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Strategies for Screening Induced Mutants for Stress Tolerance
Crop plants are exposed to a multitude of biotic and abiotic factors, which necessitates improving tolerance/resistance in plant germplasm using...
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Target-Based Screening for Lead Discovery
As a result of the enormous advances in molecular biology, recombinant technology, and genomics over the past few decades, target-based drug...
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Use of Bioinformatics in High-Throughput Drug Screening
Bioinformatics has emerged as a vital component of almost all the fields of biological sciences. Its ability to quickly generate, analyze, and...
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Elucidation of genetic determinants of dyslipidaemia using a global screening array for the early detection of coronary artery disease
Dyslipidemia is a major risk factor for the development of coronary artery disease (CAD). Understanding the genetic determinants of dyslipidemia can...
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Incidence, distribution, disease spectrum, and genetic deficits of congenital heart defects in China: implementation of prenatal ultrasound screening identified 18,171 affected fetuses from 2,452,249 pregnancies
BackgroundCongenital heart defects (CHDs) are the most common birth defects. Assessment of the incidence, distribution, disease spectrum, and genetic...
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Functional screening of congenital heart disease risk loci identifies 5 genes essential for heart development in zebrafish
Congenital heart disease (CHD) is the most common birth defect worldwide and a main cause of perinatal and infant mortality. Our previous genome-wide...
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Epidemiology, screening of isabgol (Plantago ovata Forsk.) genetic material for resistance sources to downy mildew disease and management strategies
Downy mildew caused by Peronospora plantaginis is one of the major threats to isabgol production, resulting in substantial yield losses of crop. The...
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Gestational Diabetes as a Risk Factor for Cardiovascular Disease
Gestational diabetes (GDM), defined as glucose intolerance with first recognition in pregnancy, is one of the most common medical conditions in...
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Machine learning prediction and tau-based screening identifies potential Alzheimer’s disease genes relevant to immunity
With increased research funding for Alzheimer’s disease (AD) and related disorders across the globe, large amounts of data are being generated....
