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Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosome
AbstractDesign and synthesis of conjugates consisting of the macrolide antibiotic desmycosin and fragments of the antibacterial peptide oncocin were...
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Aldsulfin, a novel unusual anti-mannheimiosis epithiodiketopiperazine antibiotic produced by Lasiodiplodia pseudotheobromae FKI-4499
An anti-mannheimiosis agent, aldsulfin, was isolated from a culture broth of the fungus Lasiodiplodia pseudotheobromae FKI-4499, together with a...
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5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity
Tylosin is a 16-membered macrolide broad-spectrum antibiotic that has an important role in veterinary medicine, active against Gram-positive and a...
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New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel
Novel fluorescent derivatives of macrolide antibiotics related to tylosin bearing rhodamine, fluorescein, Alexa Fluor 488, BODIPY FL, and...
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Natural product discovery: past, present, and future
Microorganisms have provided abundant sources of natural products which have been developed as commercial products for human medicine, animal health,...
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Residual Veterinary Pharmaceuticals in Animal Manures and Their Environmental Behaviors in Soils
The worldwide heavy use of veterinary pharmaceuticals in confined animal-feeding operations has resulted in annual discharge of 3,000–27,000 tons of...
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Type II thioesterase gene (ECO-orf27) from Amycolatopsis orientalis influences production of the polyketide antibiotic, ECO-0501 (LW01)
ECO - orf27 associated with the cluster of ECO-0501 (LW01) from Amycolatopsis orientalis is deduced to encode a type II thioesterase. Disruption of ECO -
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Amino acid and peptide derivatives of the tylosin family of macrolide antibiotics modified by aldehyde function
Fourteen new functionally active amino acid and peptide derivatives of the antibiotics tylosin, desmycosin, and 5- O -mycaminosyltylonolide were...
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Paleic acid, a fatty acid from Paenibacillus sp.: taxonomy, fermentation, isolation, structure determination, and anti-Mannheimia and -Pasteurella activity
Paleic acid (1), an antibiotic, was obtained from a fermentation broth of Paenibacillus sp. BMK771-AF3. The compound is a fatty acid (9 Z ,16 R )-16-hydro...
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Ribosomal tunnel and translation regulation
This review describes the results of recent studies of the ribosomal tunnel (RT), the major function of which is to allow the smooth passage of...
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Study of the depletion of tylosin residues in honey extracted from treated honeybee (Apis mellifera) colonies and the effect of the shook swarm procedure
Bee colonies were dosed with tylosin tartrate 1.1 g per hive (single dose in sucrose solution) and samples of honey were then collected at intervals...
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Peptide derivatives of tylosin-related macrolides
Approaches to the synthesis of model compounds based on the tylosin-related macrolides desmycosin and O =mycaminosyltylonolide were developed to study...
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Azalides from Azithromycin to New Azalide Derivatives
Azalides are semi-synthetic macrolides, in which a nitrogen atom is introduced into a macrolactone ring via a Beckmann rearrangement. Starting from...
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Synthesis of 2-Methyl 16-Membered Macrolide Derived from Tylosin
To improve the metabolic stability of a 16-membered macrolide, 2-methylated derivatives of desmycosin were synthesized. Among these derivatives,...
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Semisynthetic preparation of leucomycin derivatives: Introduction of aromatic side chains by reductive amination
A small library of leucomycin A7 derivatives was prepared by NaCNBH 3 /ZnCl 2 -mediated reductive amination of the C18 aldehyde moiety with a variety of...
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Peptide Derivatives of Antibiotics Tylosin and Desmycosin, Protein Synthesis Inhibitors
Biologically active peptide derivatives of 16-member macrolide antibiotics were synthesized as potential probes for the investigation of nascent...
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Astonishing diversity of natural surfactants: 2. Polyether glycosidic ionophores and macrocyclic glycosides
Polyether glycosidic ionophores and macrocyclic glycosides are of great interest, especially for the medicinal and pharmaceutical industries. These...