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Ribosomal tunnel and translation regulation

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Abstract

This review describes the results of recent studies of the ribosomal tunnel (RT), the major function of which is to allow the smooth passage of nascent polypeptides with different sequences from the peptidyl transferase center of the ribosome to the tunnel exit, where the folding of protein molecules begins. The features of structural organization of RT and their role in modulation and stabilization of the nascent chain conformation are discussed. Structural features of macrolide binding sites as well as application of macrolide antibiotics and their derivatives as tools to investigate ligand-tunnel wall interactions are also considered. Several examples of strong and specific interactions of regulatory polypeptides with nucleotide and amino acid residues of RT that lead to ribosome stalling and translational arrest are described in detail. The role of these events in regulation of expression of certain genes is discussed on the basis of recent high-resolution structural studies of nascent chains in the RT.

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Abbreviations

cryo-EM:

cryoelectron microscopy

FRET:

Förster (fluorescence) resonance energy transfer

PTC:

ribosome peptidyl transferase center

RT:

ribosomal tunnel

References

  1. Malkin, L. I., and Rich, A. (1967) J. Mol. Biol., 26, 329–346.

    Article  CAS  PubMed  Google Scholar 

  2. Blobel, G., and Sabatini, D. D. (1970) J. Cell. Biol., 45, 130–145.

    Article  CAS  PubMed  Google Scholar 

  3. Bernabeu, C., and Lake, J. A. (1982) Proc. Natl. Acad. Sci. USA, 79, 3111–3115.

    Article  CAS  PubMed  Google Scholar 

  4. Bernabeu, C., Tobin, E., Fowier, A., Zabin, I., and Lake, J. A. (1983) J. Cell. Biol., 96, 1471–1474.

    Article  CAS  PubMed  Google Scholar 

  5. Milligan, R. A., and Unwin, P. N. T. (1986) Nature, 319, 693–695.

    Article  CAS  PubMed  Google Scholar 

  6. Yonath, A., Leonard, K. R., and Wittmann, H. G. (1987) Science, 236, 813–816.

    Article  CAS  PubMed  Google Scholar 

  7. Ryabova, L. A., Selivanova, O. M., Baranov, V. I., Vasiliev, V. D., and Spirin, A. S. (1988) FEBS Lett., 226, 255–260.

    Article  CAS  PubMed  Google Scholar 

  8. Wang, S., Sakai, H., and Wiedmann, M. (1995) J. Cell. Biol., 130, 519–528.

    Article  CAS  PubMed  Google Scholar 

  9. Frank, J., Zhu, J., Penczek, P., Li, Y., Srivastava, S., Verschoor, A., Radermacher, M., Grassucci, R., Lata, R. K., and Agrawal, R. K. (1995) Nature, 376, 441–444.

    Article  CAS  PubMed  Google Scholar 

  10. Choi, K. M., and Brimacombe, R. (1998) Nucleic Acid Res., 15, 887–895.

    Article  Google Scholar 

  11. Mueller, F., Sommer, I., Baranov, P., Matadeen, R., Stoldt, M., Woehnert, J., Goerlach, M., van Heel, M., and Brimacombe, R. (2000) J. Mol. Biol., 298, 35–59.

    Article  CAS  PubMed  Google Scholar 

  12. Ban, N., Nissen, P., Hansen, J., Moore, P. B., and Steitz, T. A. (2000) Science, 289, 905–920.

    Article  CAS  PubMed  Google Scholar 

  13. Nissen, P., Hansen, J., Ban, N., Moore, P. B., and Steitz, T. A. (2000) Science, 289, 920–930.

    Article  CAS  PubMed  Google Scholar 

  14. Harms, J., Schluenzen, F., Zarivach, R., Bashan, A., Gat, S., Agmon, I., Bartels, H., Franceschi, F., and Yonath, A. (2001) Cell, 107, 679–688.

    Article  CAS  PubMed  Google Scholar 

  15. Brimacombe, R. (2000) Structure, 8, R195–R200.

    Article  CAS  PubMed  Google Scholar 

  16. Sergiev, P., Leonov, A., Dokudovskaya, S., Shpanchenko, O., Dontsova, O., Bogdanov, A., Rinke-Appel, J., Mueller, F., Osswald, M., von Knoblauch, K., and Brimacombe, R. (2001) Cold Spring Harb. Symp. Quant. Biol., 66, 87–100.

    Article  CAS  PubMed  Google Scholar 

  17. Sergiev, P. V., Dontsova, O. V., and Bogdanov, A. A. (2001) Mol. Biol. (Moscow), 35, 559–583.

    Article  CAS  Google Scholar 

  18. Schmeing, T. M., and Ramakrishnan, V. (2009) Nature, 461, 1234–1242.

    Article  CAS  PubMed  Google Scholar 

  19. Hardesty, B., and Kramer, G. (2001) Progr. Nucleic Acid Res. Mol. Biol., 66, 41–66.

    Article  CAS  Google Scholar 

  20. Ramu, H., Mankin, A., and Vazquez-Laslop, N. (2008) Mol. Microbiol., 71, 811–824.

    Article  PubMed  CAS  Google Scholar 

  21. Reusch, R. N., and Sadoff, H. L. (1988) Proc. Natl. Acad. Sci. USA, 85, 4176–4180.

    Article  CAS  PubMed  Google Scholar 

  22. Reusch, R. N. (2000) Biochemistry (Moscow), 65, 280–295.

    CAS  Google Scholar 

  23. Rospert, S. (2004) Curr. Biol., 14, R386–R388.

    Article  CAS  PubMed  Google Scholar 

  24. Mears, J. A., Cannone, J. J., Stegg, S. M., Guttell, R. R., Agrawal, R. K., and Harvey, S. C. (2002) J. Mol. Biol., 321, 215–234.

    Article  CAS  PubMed  Google Scholar 

  25. Sharma, M. R., Booth, T. M., Simpson, L., Maslov, D. A., and Agrawal, R. K. (2009) Proc. Natl. Acad. Sci. USA, 106, 9637–9642.

    Article  CAS  PubMed  Google Scholar 

  26. Kovalskaya, O. M., Sergiev, P. V., Bogdanov, A. A., and Dontsova, O. A. (2007) Uspekhi Biol. Khim., 47, 129–188.

    CAS  Google Scholar 

  27. Kramer, G., Boehringer, D., Ban, N., and Bukau, B. (2009) Nat. Struct. Mol. Biol., 16, 589–597.

    Article  CAS  PubMed  Google Scholar 

  28. Giglione, C., Filulaine, S., and Meinnel, T. (2009) Trends Biochem. Sci., 34, 417–426.

    Article  CAS  PubMed  Google Scholar 

  29. Lu, J., Kobertz, W. R., and Deutsch, C. (2007) J. Mol. Biol., 371, 1378–1391.

    Article  CAS  PubMed  Google Scholar 

  30. Lu, J., and Deutsch, C. (2005) Nat. Struct. Biol., 12, 1123–1129.

    Article  CAS  Google Scholar 

  31. Lu, J., and Deutsch, C. (2008) J. Mol. Biol., 384, 73–86.

    Article  CAS  PubMed  Google Scholar 

  32. Voss, N. R., Gerstein, M., Steitz, T. M., and Moore, P. B. (2006) J. Mol. Biol., 360, 893–906.

    Article  CAS  PubMed  Google Scholar 

  33. Steitz, T. A. (2008) Nat. Rev. Mol. Cell Biol., 9, 242–253.

    Article  CAS  PubMed  Google Scholar 

  34. Spirin, A. S. (2009) J. Biol. Chem., 284, 21103–21119.

    Article  CAS  PubMed  Google Scholar 

  35. Valle, M., Zavialov, A., Sengupta, J., Rawat, U., Ehrenberg, M., and Frank, J. (2003) Cell, 114, 123–134.

    Article  CAS  PubMed  Google Scholar 

  36. Schmeing, T. M., Voorhees, R. M., Kelly, A. C., Gao, Y. G., Murphy, F. V., 4th, Weir, J. R., and Ramakrishnan, V. (2009) Science, 326, 688–694.

    Article  CAS  PubMed  Google Scholar 

  37. Gao, Y. G., Selmer, M., Dunham, C. M., Weixbaumer, A., Kelly, A. C., and Ramakrishnan, V. (2009) Science, 326, 694–699.

    Article  CAS  PubMed  Google Scholar 

  38. Gabashvili, I. S., Grgory, S. T., Valle, M., Grassucci, R., Worbs, M., Wahl, M. C., Dahlberg, A. T., and Frank, J. (2001) Mol. Cell, 8, 181–188.

    Article  CAS  PubMed  Google Scholar 

  39. Gilbert, R. J., Fucini, P., Connel, S., Fuller, S. D., Nierhaus, K. H., Robinson, C. V., Dobson, C. M., and Stuart, D. I. (2004) Mol. Cell, 14, 57–66.

    Article  CAS  PubMed  Google Scholar 

  40. Fulle, S., and Gohlke, H. (2009) J. Mol. Biol., 387, 502–517.

    Article  CAS  PubMed  Google Scholar 

  41. Sergiev, P. V., Bogdanov, A. A., and Dontsova, O. A. (2005) FEBS Lett., 579, 5439–5442.

    CAS  PubMed  Google Scholar 

  42. Kiparisov, S. V., Sergiev, P. V., Bogdanov, A. A., and Dontsova, O. A. (2006) Mol. Biol. (Moscow), 40, 755–768.

    CAS  Google Scholar 

  43. Halic, M., Becker, T., Pool, M. R., Spahn, C. M., Grassucci, R. A., Frank, J., and Beckmann, R. (2004) Nature, 427, 808–814.

    Article  CAS  PubMed  Google Scholar 

  44. Halic, M., Becker, T., Mielke, T., Pool, M. R., Wild, K., Sinning, I., and Beckmann, R. (2006) Nature, 444, 507–511.

    Article  CAS  PubMed  Google Scholar 

  45. Schaffitzel, C., and Ban, N. (2007) J. Struct. Biol., 158, 463–471.

    Article  CAS  PubMed  Google Scholar 

  46. Seidelt, B., Innis, C. F., Wilson, D. N., Gartmann, M., Armache, J.-P., Villa, E., Trabuco, L. G., Becker, T., Mielke, T., Schulten, K., Steitz, T. A., and Beckmann, R. (2009) Science, 326, 1412–1415.

    Article  CAS  PubMed  Google Scholar 

  47. Becker, T., Bhushan, S., Jarasch, A., Armache, J.-P., Funes, S., Jossinet, F., Gumbart, J., Mielke, T., Berninghausen, O., Schulten, K., Westhof, E., Gilmore, R., Mandon, E. C., and Beckmann, R. (2009) Science, 326, 1369–1373.

    Article  CAS  PubMed  Google Scholar 

  48. Woolhead, C. A., McCormick, P. J., and Johnson, A. E. (2004) Cell, 116, 725–736.

    Article  CAS  PubMed  Google Scholar 

  49. Kosolapov, A., and Deutsch, C. (2009) Nat. Struct. Biol., 16, 405–411.

    Article  CAS  Google Scholar 

  50. Tu, L., and Deutsch, C. (2010) J. Mol. Biol., 396, 1346–1350.

    Article  CAS  PubMed  Google Scholar 

  51. Lim, V. I., and Spirin, A. S. (1986) J. Mol. Biol., 188, 565–577.

    Article  CAS  PubMed  Google Scholar 

  52. Bhushan, S., Gartmann, M., Halic, M., Armache, J.-P., Jarasch, A., Mielke, T., Berninghausen, O., Wilson, D. N., and Beckmann, R. (2010) Nat. Struct. Biol., 17, 313–317.

    Article  CAS  Google Scholar 

  53. Marqusee, S., and Baldwin, R. L. (1987) Proc. Natl. Acad. Sci. USA, 84, 8898–8902.

    Article  CAS  PubMed  Google Scholar 

  54. Sicheri, F., and Yang, D. S. (1995) Nature, 375, 427–431.

    Article  CAS  PubMed  Google Scholar 

  55. Barron, L. D., Hecht, L., and Wilson, G. (1997) Biochemistry, 36, 13143–13147.

    Article  CAS  PubMed  Google Scholar 

  56. Mankin, A. (2001) Mol. Biol. (Moscow), 35, 597–609.

    CAS  Google Scholar 

  57. Wilson, D. N., Harms, J. M., Nierhaus, K. H., Schluenzen, F., and Fucini, P. (2005) Biol. Chem., 386, 1239–1252.

    Article  CAS  PubMed  Google Scholar 

  58. Wimberly, B. T. (2009) Curr. Opin. Investig. Drugs, 10, 750–765.

    CAS  PubMed  Google Scholar 

  59. Schlunzen, F., Zarivach, R., Harms, J., Bashan, A., Tocilj, A., Albrecht, R., Yonath, A., and Franceschi, F. (2001) Nature, 413, 814–821.

    Article  CAS  PubMed  Google Scholar 

  60. Hansen, J., Ippolito, J. A., Ban, N., Nissen, P., Moore, P. B., and Steitz, T. A. (2002) Mol. Cell, 10, 117–128.

    Article  CAS  PubMed  Google Scholar 

  61. Omura, S. (2002) Macrolide Antibiotics: Chemistry, Biology and Practice, 2nd Edn., Academic Press.

  62. Hansen, L. H., Mauvais, P., and Douthwaite, S. (1999) Mol. Microbiol., 31, 623–631.

    Article  CAS  PubMed  Google Scholar 

  63. Moazed, D., and Noller, H. F. (1987) Biochemie, 69, 879–884.

    Article  CAS  Google Scholar 

  64. Poulsen, S. M., Kofoed, C., and Vester, B. (2000) J. Mol. Biol., 304, 471–481.

    Article  CAS  PubMed  Google Scholar 

  65. Liu, M., and Douthwaite, S. (2002) Proc. Natl. Acad. Sci. USA, 99, 14658–14663.

    Article  CAS  PubMed  Google Scholar 

  66. Lai, C. J., and Weisblum, B. (1971) Proc. Natl. Acad. Sci. USA, 68, 856–860.

    Article  CAS  PubMed  Google Scholar 

  67. Skinner, R., Cundliffe, E., and Schmidt, F. J. (1983) J. Biol. Chem., 258, 12702–12706.

    CAS  PubMed  Google Scholar 

  68. Douthwaite, S. (1992) J. Bacteriol., 174, 1333–1338.

    CAS  PubMed  Google Scholar 

  69. Sigmund, C. D., and Morgan, E. A. (1982) Proc. Natl. Acad. Sci. USA, 79, 5602–5606.

    Article  CAS  PubMed  Google Scholar 

  70. Weisblum, B. (1995) Antimicrob. Agents Chemother., 39, 577–585.

    CAS  PubMed  Google Scholar 

  71. Vester, B., and Douthwaite, S. (2001) Antimicrob. Agents Chemother., 45, 1–12.

    Article  CAS  PubMed  Google Scholar 

  72. Gregory, S. T., and Dahlberg, A. E. (1999) J. Mol. Biol., 289, 827–834.

    Article  CAS  PubMed  Google Scholar 

  73. Garza-Ramos, G., **ong, L., Zhong, P., and Mankin, A. (2001) J. Bacteriol., 183, 6898–6907.

    Article  CAS  PubMed  Google Scholar 

  74. Petropoulos, A. D., Kouvela, E. C., Dinos, G. P., and Kalpaxis, D. L. (2008) J. Biol. Chem., 283, 4756–4765.

    Article  CAS  PubMed  Google Scholar 

  75. Rodriguez-Fonseca, C., Amils, R., and Garrett, R. A. (1995) J. Mol. Biol., 247, 224–235.

    Article  CAS  PubMed  Google Scholar 

  76. Auerbach, T., Bashan, A., and Yonath, A. (2004) Trends Biotechnol., 22, 570–576.

    Article  CAS  PubMed  Google Scholar 

  77. Steitz, T. A. (2005) FEBS Lett., 579, 955–958.

    Article  CAS  PubMed  Google Scholar 

  78. Tu, D., Blaha, G., Moore, P. B., and Steitz, T. A. (2005) Cell, 121, 257–270.

    Article  CAS  PubMed  Google Scholar 

  79. Vazquez-Laslop, N., Thum, C., and Mankin, A. S. (2008) Mol. Cell, 30, 190–202.

    Article  CAS  PubMed  Google Scholar 

  80. Tenson, T., Lovmar, M., and Ehrenberg, M. (2003) J. Mol. Biol., 330, 1005–1014.

    Article  CAS  PubMed  Google Scholar 

  81. Matsuoka, M., Inoue, M., Endo, Y., and Nakajima, Y. (2003) FEMS Microbiol. Lett., 220, 287–293.

    Article  CAS  PubMed  Google Scholar 

  82. Furneri, P. M., Rapazzo, G., Musumarra, M., Pietro, P., Catania, L. S., and Roccasalva, L. S. (2001) Antibiot. Chemother., 45, 2958–2960.

    Article  CAS  Google Scholar 

  83. Sutcliffe, J. A. (2004) Features, 70, 513–519.

    Google Scholar 

  84. Douthwaite, S., Crain, P. F., Liu, M., and Poehlsgaard, J. (2004) J. Mol. Biol., 337, 1073–1077.

    Article  CAS  PubMed  Google Scholar 

  85. Pfister, P., Corti, N., Hobbie, S., Bruell, C., Zarivach, R., Yonath, A., and Bottger, E. C. (2005) Proc. Natl. Acad. Sci. USA, 102, 5180–5185.

    Article  CAS  PubMed  Google Scholar 

  86. Mankin, A. S. (2008) Curr. Opin. Microbiol., 11, 414–421.

    Article  CAS  PubMed  Google Scholar 

  87. Schroeder, S. J., Blaha, G., and Moore, P. B. (2007) Antimicrob. Agents Chemother., 51, 4462–4465.

    Article  CAS  PubMed  Google Scholar 

  88. Sumbatyan, N. V., Korshunova, G. A., and Bogdanov, A. A. (2003) Biochemistry (Moscow), 68, 1156–1158.

    Article  CAS  Google Scholar 

  89. Korshunova, G. A., Sumbatyan, N. V., Fedorova, N. V., Kuznetsova, I. V., Shishkina, A. V., and Bogdanov, A. A. (2007) Bioorg. Khim., 33, 235–244.

    CAS  PubMed  Google Scholar 

  90. Sumbatyan, N. V., Kuznetsova, I. V., Karpenko, V. V., Fedorova, N. V., Chertkov, V. A., Korshunova, G. A., and Bogdanov, A. A. (2010) Bioorg. Khim., 36, 265–276.

    Google Scholar 

  91. Starosta, A. L., Karpenko, V. V., Shishkina, A. V., Mikolajka, A., Sumbatyan, N. V., Schluenzen, F., Korshunova, G. A., Bogdanov, A. A., and Wilson, D. N. (2010) Chem. Biol., 17, 504–514.

    Article  CAS  PubMed  Google Scholar 

  92. Lovett, P. S., and Rogers, E. J. (1996) Microbiol. Rev., 60, 366–385.

    CAS  PubMed  Google Scholar 

  93. Morris, D. R., and Geballe, A. P. (2000) Mol. Cell Biol., 20, 8635–8642.

    Article  CAS  PubMed  Google Scholar 

  94. Tenson, T., and Ehrenberg, M. (2002) Cell, 108, 591–594.

    Article  CAS  PubMed  Google Scholar 

  95. Nakatogawa, H., and Ito, K. (2002) Cell, 108, 629–636.

    Article  CAS  PubMed  Google Scholar 

  96. Gong, F., and Yanofsky, C. (2002) Science, 297, 1864–1867.

    Article  CAS  PubMed  Google Scholar 

  97. Vazquez-Laslop, N., Thum, C., and Mankin, A. S. (2008) Mol. Cell, 30, 190–202.

    Article  CAS  PubMed  Google Scholar 

  98. Wang, Z., Fang, P., and Sachs, M. (1997) Mol. Cell Biol., 18, 7528–7536.

    Google Scholar 

  99. Raney, A., Law, G. L., Mize, G. J., and Morris, D. R. (2002) J. Biol. Chem., 277, 5988–5994.

    Article  CAS  PubMed  Google Scholar 

  100. Lovett, P. S. (1994) J. Bacteriol., 176, 6415–6417.

    CAS  PubMed  Google Scholar 

  101. Gu, Z., Harrod, R., Rogers, E. J., and Lovett, P. S. (1994) Proc. Natl. Acad. Sci. USA, 91, 5612–5616.

    Article  CAS  PubMed  Google Scholar 

  102. Rogers, E. J., and Lovett, P. S. (1994) Mol. Microbiol., 12, 181–186.

    Article  CAS  PubMed  Google Scholar 

  103. Weisblum, B. (1995) Antimicrob. Agents Chemother., 39, 797–805.

    CAS  PubMed  Google Scholar 

  104. Ramu, H., Mankin, A., and Vasquez-Laslop, N. (2008) Mol. Microbiol., 71, 811–824.

    Article  PubMed  CAS  Google Scholar 

  105. Bayfield, M. A., Thompson, J., and Dahlberg, A. E. (2004) Nucleic Acids Res., 32, 5512–5518.

    Article  CAS  PubMed  Google Scholar 

  106. Nakatogawa, H., and Ito, K. (2004) ChemBioChem, 5, 48–51.

    Article  CAS  PubMed  Google Scholar 

  107. Muto, H., Nakatogawa, H., and Ito, K. (2006) Mol. Cell, 22, 545–552.

    Article  CAS  PubMed  Google Scholar 

  108. Pavlov, M. Y., Watts, R. E., Tan, Z., Cornish, V. W., Ehrenberg, M., and Forster, A. C. (2009) Proc. Natl. Acad. Sci. USA, 106, 50–54.

    Article  CAS  PubMed  Google Scholar 

  109. Muto, H., and Ito, K. (2008) Biochem. Biophys. Res. Commun., 366, 1043–1047.

    Article  CAS  PubMed  Google Scholar 

  110. Wohlgemuth, I., Brenner, S., Beringer, M., and Rodnina, M. V. (2008) J. Biol. Chem., 283, 32229–32235.

    Article  CAS  PubMed  Google Scholar 

  111. Suhonara, T., Abo, T., Inada, T., and Aiba, H. (2002) RNA, 8, 1416–1427.

    Article  CAS  Google Scholar 

  112. Roche, E. D., and Sauer, R. T. (2001) J. Biol. Chem., 276, 28509–28515.

    Article  CAS  PubMed  Google Scholar 

  113. Tanner, D. R., Carillo, D. A., Woolstenhulme, C. J., Broadbent, M. A., and Buskirk, A. R. (2009) J. Biol. Chem., 284, 34809–34818.

    Article  CAS  PubMed  Google Scholar 

  114. Shpanchenko, O. V., Ivanov, P. V., Zvereva, M. E., Bogdanov, A. A., and Dontsova, O. A. (2004) Mol. Biol. (Moscow), 38, 914–925.

    Article  Google Scholar 

  115. Woolhead, C. A., Johnson, A. E., and Bernstein, H. D. (2006) Mol. Cell, 22, 587–598.

    Article  CAS  PubMed  Google Scholar 

  116. Yap, M.-N., and Bernstein, H. D. (2009) Mol. Cell, 34, 201–211.

    Article  CAS  PubMed  Google Scholar 

  117. Schmeing, T. M., Seila, A. C., Hansen, J. L., Freeborn, B., Soukup, J. K., Scaringe, S. A., Strobel, S. A., Moore, P. B., and Steitz, T. A. (2002) Nat. Struct. Biol., 9, 225–230.

    CAS  PubMed  Google Scholar 

  118. Hansen, J. L., Schmeing, T. M., Moore, P. B., and Steitz, T. A. (2002) Proc. Natl. Acad. Sci. USA, 99, 11670–11675.

    Article  CAS  PubMed  Google Scholar 

  119. Bogdanov, A. A. (2003) Mol. Biol. (Moscow), 37, 436–439.

    Article  CAS  Google Scholar 

  120. Wang, D., Ding, X., and Rather, P. N. (2001) J. Bacteriol., 183, 4210–4216.

    Article  CAS  PubMed  Google Scholar 

  121. Ren, D., Bedzyk, L. A., Ye, R. W., Thomas, S. M., and Wood, T. K. (2004) Appl. Environ. Microbiol., 70, 2038–2043.

    Article  CAS  PubMed  Google Scholar 

  122. Hirakawa, H., Inazumi, Y., Masaki, T., Hirata, T., and Yamaguchi, A. (2005) Mol. Microbiol., 55, 1113–1126.

    Article  CAS  PubMed  Google Scholar 

  123. Kazarinoff, M. N., and Snell, E. E. (1977) J. Biol. Chem., 252, 7598–7602.

    CAS  PubMed  Google Scholar 

  124. Gollnicky, P., and Yanofsky, C. J. (1990) J. Bacteriol., 172, 3100–3107.

    Google Scholar 

  125. Gong, F., and Yanofsky, C. (2001) J. Biol. Chem., 276, 1974–1983.

    CAS  PubMed  Google Scholar 

  126. Yanofsky, C. (2007) RNA, 13, 1141–1154.

    Article  CAS  PubMed  Google Scholar 

  127. Gong, F., Ito, K., Nakamura, Y., and Yanofsky, C. (2001) Proc. Natl. Acad. Sci. USA, 98, 8997–9001.

    Article  CAS  PubMed  Google Scholar 

  128. Gong, M., Cruz-Vera, L. R., and Yanofsky, C. (2007) J. Bacteriol., 189, 3147–3155.

    Article  CAS  PubMed  Google Scholar 

  129. Cruz-Vera, L. R., Rajagopal, S., Squires, C., and Yanofsky, C. (2005) Mol. Cell, 19, 333–343.

    Article  CAS  PubMed  Google Scholar 

  130. Cruz-Vera, L. R., New, A., Squires, C., and Yanofsky, C. (2007) J. Bacteriol., 189, 3140–3146.

    Article  CAS  PubMed  Google Scholar 

  131. Mankin, A. S. (2006) Trends Biochem. Sci., 31, 11–13.

    Article  CAS  PubMed  Google Scholar 

  132. Torrice, M. M., Bower, K. S., Lester, H. A., and Dougherty, D. A. (2009) Proc. Natl. Acad. Sci. USA, 106, 11919–11924.

    Article  CAS  PubMed  Google Scholar 

  133. Trabuco, L. G., Harrison, C. B., Schreiner, E., and Schulten, K. (2010) Structure, 18, 627–637.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Belozersky Institute of Physico-Chemical Biology and Chemical Faculty, Lomonosov Moscow State University, 119991, Moscow, Russia

    A. A. Bogdanov, N. V. Sumbatyan, A. V. Shishkina, V. V. Karpenko & G. A. Korshunova

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Correspondence to A. A. Bogdanov.

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Original Russian Text © A. A. Bogdanov, N. V. Sumbatyan, A. V. Shishkina, V. V. Karpenko, G. A. Korshunova, 2010, published in Uspekhi Biologicheskoi Khimii, 2010, Vol. 50, pp. 5–42.

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Bogdanov, A.A., Sumbatyan, N.V., Shishkina, A.V. et al. Ribosomal tunnel and translation regulation. Biochemistry Moscow 75, 1501–1516 (2010). https://doi.org/10.1134/S0006297910130018

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