Search
Search Results
-
Prioritised identification of structural classes of natural products from higher plants in the expedition of antimalarial drug discovery
The emergence and spread of drug-recalcitrant Plasmodium falciparum parasites threaten to reverse the gains made in the fight against malaria. Urgent...
-
Evaluation of xanthene-appended quinoline hybrids as potential leads against antimalarial drug targets
AbstractA series of fused heterocycle xanthene-appended quinoline 6a–n was successfully synthesized with regioselectivity and characterized using IR,
-
Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis
BackgroundMalaria remains a global health burden, and the emergence and increasing spread of drug resistance to current antimalarials poses a major...
-
Distribution patterns of molecular markers of antimalarial drug resistance in Plasmodium falciparum isolates on the Thai-Myanmar border during the periods of 1993–1998 and 2002–2008
BackgroundPolymorphisms of Plasmodium falciparum chloroquine resistance transporter ( pfcrt ), Plasmodium falciparum multi-drug resistance 1 ( pfmdr1 )...
-
New antimalarial iromycin analogs produced by Streptomyces sp. RBL-0292
Two new antimalarial compounds, named prenylpyridones A ( 1 ) and B ( 2 ), were discovered from the actinomycete cultured material of Streptomyces sp....
-
Targeting antimalarial metabolites from the actinomycetes associated with the Red Sea sponge Callyspongia siphonella using a metabolomic method
Malaria is a persistent illness that is still a public health issue. On the other hand, marine organisms are considered a rich source of...
-
Hydroxychloroquine an Antimalarial Drug, Exhibits Potent Antifungal Efficacy Against Candida albicans Through Multitargeting
Candida albicans is the primary etiological agent associated with candidiasis in humans. Unrestricted growth of C. albicans can progress to systemic...
-
Structure-based virtual screening against multiple Plasmodium falciparum kinases reveals antimalarial compounds
The continuous emergence of resistance against most frontline antimalarial drugs has led to countless deaths in malaria-endemic countries, counting...
-
Sheptide A: an antimalarial cyclic pentapeptide from a fungal strain in the Herpotrichiellaceae
As part of ongoing efforts to isolate biologically active fungal metabolites, a cyclic pentapeptide, sheptide A ( 1 ), was discovered from strain...
-
Pharmacology of Manilkara hexandra leaf extract: potent antimalarial by targeting β-hematin formation and pro-inflammatory cytokine investigation
The renewed interest in the bioprospecting of medicinal plants to treat malaria for the endemic population at times of resistance and...
-
Leveraging off higher plant phylogenetic insights for antiplasmodial drug discovery
The antimalarial drug-resistance conundrum which threatens to reverse the great strides taken to curb the malaria scourge warrants an urgent need to...
-
New antimalarial fusarochromanone analogs produced by the fungal strain Fusarium sp. FKI-9521
Two new antimalarial compounds, named deacetyl fusarochromene ( 1 ) and 4′- O -acetyl fusarochromanone ( 2 ), were discovered from the static fungal...
-
Synthesis and antimalarial activity of amide and ester conjugates of siderophores and ozonides
Despite advances in chemotherapeutic interventions for the treatment of malaria, there is a continuing need for the development of new antimalarial...
-
Exploring the antimalarial and antioxidant efficacy of transition metal(II) chelates of thiosemicarbazone ligands: spectral investigations, molecular docking, DFT, MESP and ADMET
Malaria, a relentless and ancient adversary, continues to cast its shadow over vast swathes of the globe, afflicting millions of people and have a...
-
Drug resistance and vaccine target surveillance of Plasmodium falciparum using nanopore sequencing in Ghana
Malaria results in over 600,000 deaths annually, with the highest burden of deaths in young children living in sub-Saharan Africa. Molecular...
-
The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures
BackgroundBy 2016, signs of emergence of Plasmodium falciparum resistance to artemisinin and partner drugs were detected in the Greater Mekong...
-
Quinolone scaffolds as potential drug candidates against infectious microbes: a review
Prevalence of microbial infections and new rising pathogens are signified as causative agent for variety of serious and lethal health crisis in past...
-
Identifying Fast and Slow-Acting Antimalarial Compounds of Pandemic Response Box Against Blood-Stage Culture of Plasmodium falciparum 3D7
The evolving clinical resistance in Plasmodium falciparum and the spike in malarial cases after the COVID-19 outbreak has triggered a search for new...
-
Variation in terpenoids in leaves of Artemisia annua grown under different LED spectra resulting in diverse antimalarial activities against Plasmodium falciparum
BackgroundProductivities of bioactive compounds in high-value herbs and medicinal plants are often compromised by uncontrollable environmental...
-
Drug Repurposing: An Effective Tool in Modern Drug Discovery
AbstractDrug repurposing is using an existing drug for a new treatment that was not indicated before. It has received immense attention during the...
