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Mutation Work on Other Ornamental Plants
The chapter covers mutation work (mutagens, working dose, mutants) carried out throughout the world on approximately 120 ornamental crops.
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Mutation Breeding Research in Sweet Pepper
Sweet pepper is delicious, loved, and an increasingly popular nutritional vegetable that is grown and produced in significant amounts throughout the...
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In silico analysis of the Val66Met mutation in BDNF protein: implications for psychological stress
The brain-derived neurotrophic factor (BDNF) involves stress regulation and psychiatric disorders. The Val66Met polymorphism in the BDNF gene has...
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Protocol on Mutation Induction in Coffee Using In Vitro Tissue Cultures
Pathogens are the major limiting factors in coffee production. Approximately 26% of the global annual coffee production is lost to diseases,...
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A compound heterozygous mutation of ERCC8 is responsible for a family with Cockayne syndrome
BackgroundCockayne syndrome is an inherited heterogeneous defect in transcription-coupled DNA repair (TCR) cause severe clinical syndromes, which may...
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Landscape of KRAS, BRAF, and PIK3CA Mutations and Clinical Features of EBV-Associated and Microsatellite Unstable Gastric Cancer
AbstractPersonalization of gastric cancer (GC) treatment is an urgent problem because of the clinical heterogeneity and aggressive course of the...
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Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers
Chromosomal instability (CIN) is a hallmark of cancer, caused by persistent errors in chromosome segregation during mitosis. Aggressive cancers like...
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Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering
Mutations in amino acid sequences can provoke changes in protein function. Accurate and unsupervised prediction of mutation effects is critical in...
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Harnessing the potential of mutation breeding, CRISPR genome editing, and beyond for sustainable agriculture
By 2050, the global population is projected to exceed 9.5 billion, posing a formidable challenge to ensure food security worldwide. To address this...
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Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers
Mutations in human cells exhibit increased burden in heterochromatic, late DNA replication time (RT) chromosomal domains, with variation in mutation...
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Characterization of immortalized ovarian epithelial cells with BRCA1/2 mutation
We aimed to elucidate the mechanism underlying carcinogenesis by comparing normal and BRCA1/2- mutated ovarian epithelial cells established via Sendai...
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Ultrasensitive quantitation of FLT3-ITD mutation in patients with acute myeloid leukemia using ddPCR
BackgroundFLT3 -ITD mutations occur in 45–50% of cytogenetically normal AML patients. Conventional fragment analysis using capillary electrophoresis...
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Mutation-class dependent signatures outweigh disease-associated processes in cystic fibrosis cells
BackgroundThe phenotypic heterogeneity observed in Cystic Fibrosis (CF) patients suggests the involvement of other genes, besides CFTR . Here, we...
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A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis
Light chain (AL) amyloidosis is a debilitating disease in which mutant antibody light chains (LC), secreted by aberrant plasma cell clones, misfold...
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Concurrent classic driver oncogenes mutation with ROS1 rearrangement predicts superior clinical outcome in NSCLC patients
BackgroundThere is high mortality rate and poor prognosis in lung cancer, especially non-small-cell lung cancer (NSCLC). Recent study showed that...
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Assessing the reliability of point mutation as data augmentation for deep learning with genomic data
BackgroundDeep neural networks (DNNs) have the potential to revolutionize our understanding and treatment of genetic diseases. An inherent limitation...
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Establishment and characterization of a novel dedifferentiated chondrosarcoma cell line, SMU-DDCS, harboring an IDH1 mutation
Dedifferentiated chondrosarcoma (DDCS) is a high-grade subtype with a bi-morphic histological appearance of a conventional chondrosarcoma component...
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Mutation map** of a variegated EMS tomato reveals an FtsH-like protein precursor potentially causing patches of four phenotype classes in the leaves with distinctive internal morphology
BackgroundLeaf variegation is an intriguing phenomenon observed in many plant species. However, questions remain on its mechanisms causing patterns...
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A novel missense mutation in the CRYBA2 caused autosomal dominant presenile cataract in a Chinese family
Presenile cataract is a relatively rare type of cataract, but its genetic mechanisms are currently not well understood. The precise identification of...
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How mutation shapes the rate of population spread in the presence of a mate-finding Allee effect
Although past work has considered how evolution and Allee effects each shape population spread, these factors have rarely been considered together....
