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Autologous mesenchymal stem cell transplantation for spinal fusion: 10 years follow-up of a phase I/II clinical trial
Posterolateral spinal fusion is the standard surgical approach for patients with degenerative disc disease. In our previously published article, we...
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Surgical management of spinal pathologies in the octogenarian: a narrative review
Optimal management paradigms of spinal pathologies in the octogenarian population are controversial given the higher incidence of comorbidities with...
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Comparison of demineralized bone matrix with different cycling crushing times in posterolateral fusion model of athymic rats
Decalcified bone matrix (DBM) is a widely used alternative material for bone transplantation. In the DBM production process, an effective particle...
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Intraoperative Cardiovascular Emergency in Spinal Melioidosis Presenting as a Case of Spinal Epidural Abscess: A Rare Case Study of 2 Patients
Melioidosis rarely presents with spinal involvement, which may lead to neurological complications. It's endemic to Thailand and Australia, but rare...
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Electromagnetic field stimulation facilitates motor neuron excitability, myogenesis and muscle contractility in spinal cord transected rats
Spinal cord injury (SCI) is one of the most devastating injuries which causes either complete or partial loss of movement, balance, muscular...
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MYCN immunohistochemistry as surrogate marker for MYCN-amplified spinal ependymomas
MYCN (master regulator of cell cycle entry and proliferative metabolism) gene amplification defines a molecular subgroup of spinal cord ependymomas...
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The impact of social determinants of health on early outcomes after adult Chiari surgery
We sought to identify social determinants of health (SDoH) for adult patients undergoing Chiari decompression surgery and to analyze their...
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Spinal cord injury dysregulates fibro-adipogenic progenitors miRNAs signaling to promote neurogenic heterotopic ossifications
Neurogenic heterotopic ossifications are intramuscular bone formations develo** following central nervous system injury. The pathophysiology is...
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UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury
Activation of endogenous neural stem cells (NSCs) is greatly significant for the adult neurogenesis; however, it is extremely limited in the spinal...
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Controlling the Immune Response to Zebrafish Spinal Cord Injury via Extracellular Vesicles Secreted by Activated Monocyte-like Cells
AbstractThe immune response to spinal cord injury (SCI) is implemented via local and systemic inflammation, followed by repair and...
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A slow-releasing donor of hydrogen sulfide inhibits neuronal cell death via anti-PANoptosis in rats with spinal cord ischemia‒reperfusion injury
BackgroundSpinal cord ischemia‒reperfusion injury (SCIRI) can lead to paraplegia, which leads to permanent motor function loss. It is a disastrous...
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Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice
Spinal cord injury (SCI) could lead to severe disabilities in motor and sensory functions, and cause a heavy burden on patient physiology and...
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Advancing Use of DEXA Scans to Quantitatively and Qualitatively Evaluate Lateral Spinal Curves, for Preliminary Identification of Adolescent Idiopathic Scoliosis
Dual-energy X-ray absorptiometry (DEXA) scan is an emerging screening method for identifying likely adolescent idiopathic scoliosis (AIS). Using DEXA...
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Mitochondrial transplantation protects against sepsis-induced myocardial dysfunction by modulating mitochondrial biogenesis and fission/fusion and inflammatory response
BackgroundSepsis-induced myocardial dysfunction is associated with worse clinical outcomes and high mortality, but no effective therapeutic...
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Pathophysiology of Spinal Cord Injury and Tissue Engineering Approach for Its Neuronal Regeneration: Current Status and Future Prospects
A spinal cord injury (SCI) is a very debilitating condition causing loss of sensory and motor function as well as multiple organ failures. Current...
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Evaluating osteoporosis and bone quality in the aging spine: modern considerations for surgical management in the geriatric population
Surgical management paradigms of spinal pathologies in the aging population carry inherent substantial risks, with surgical complications being more...
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Low-frequency electromagnetic fields combined with tissue engineering techniques accelerate intervertebral fusion
BackgroundIntervertebral fusion is the most common surgery to treat lumbar degenerative disease (LDD). And the graft material used in the operation...
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Restoration of ER proteostasis attenuates remote apoptotic cell death after spinal cord injury by reducing autophagosome overload
The pathogenic mechanisms that underlie the progression of remote degeneration after spinal cord injury (SCI) are not fully understood. In this...
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A non-invasive system to monitor in vivo neural graft activity after spinal cord injury
Expectations for neural stem/progenitor cell (NS/PC) transplantation as a treatment for spinal cord injury (SCI) are increasing. However, whether and...
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Allogenic bone grafts and postoperative surgical site infection: are positive intraoperative swab cultures predictive for a higher infectious risk?
In spine surgery, allogenic bone grafts are often required to ensure bone fusion, however, the main concern regarding their use is the infection...
