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Monoterpene indole alkaloids with anticancer activity from Tabernaemontana species
Indole alkaloids, predominantly found in plants, are a large group of natural product-derived compounds characterized by a remarkable chemical...
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The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids
Monoterpene indole alkaloids (MIAs) are a structurally diverse family of specialized metabolites mainly produced in Gentianales to cope with...
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Plant cytochrome P450s directing monoterpene indole alkaloid (MIA) and benzylisoquinoline alkaloid (BIA) biosynthesis
The large family of cytochrome P450 enzymes are heme containing proteins generally associated with the cytoplasmic face of the endoplasmic reticulum...
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Reconstitution of monoterpene indole alkaloid biosynthesis in genome engineered Nicotiana benthamiana
Monoterpene indole alkaloids (MIAs) are a diverse class of plant natural products that include a number of medicinally important compounds. We set...
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A review on the genus Melodinus: traditional uses, phytochemical diversity and pharmacological activities of indole alkaloids
Indole alkaloids are an important group of natural products in the plant kingdom for their diversity structures and significant biological effects on...
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Phytochemistry and Pharmacology of Catharanthus roseus (L.) G. Don and Rauvolfia serpentina (L.) Benth. ex Kurz
Catharanthus roseus (L.) G.Don and Rauvolfia serpentina (L.) Benth. ex Kurz are well-known medicinal plants belonging to the family Apocynaceae that...
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Nitrogen-Containing Compounds
Nitrogen-containing compounds include three main metabolic classes: alkaloids, cyanogenic glucosides and glucosinolates. Alkaloids show the most...
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Alkaloid diversification in the genus Palicourea (Rubiaceae: Palicoureeae) viewed from a (retro-)biogenetic perspective
The species-rich genus Palicourea (Rubiaceae: Palicoureeae) is source of an intriguing diversity of alkaloids derived from tryptamine and its...
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Engineering Catharanthus roseus monoterpenoid indole alkaloid pathway in yeast
AbstractCatharanthus roseus (Madagascar periwinkle), a medicinal plant possessing high pharmacological attributes, is widely recognized for the...
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A revised classification of the sister tribes Palicoureeae and Psychotrieae (Rubiaceae) indicates genus-specific alkaloid accumulation
Tribes Palicoureeae and Psychotrieae (Rubiaceae, Gentianales) are complex and speciose sister groups with a pantropical distribution. Since the...
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Agrobacterium-Mediated in Planta Transformation in Periwinkle
Madagascar periwinkle (Catharanthus roseus, family Apocynaceae) is a reservoir of more than 130 monoterpene indole alkaloids (MIAs) including the...
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Sequencing the Genome of Catharanthus roseus: Status and Prospects
Catharanthus roseus is a highly valuable plant often used for its medicinal applications. This plant synthesizes potent antitumor drugs known as...
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Terpenoid indole alkaloid biosynthesis in Catharanthus roseus: effects and prospects of environmental factors in metabolic engineering
AbstractPlants synthesize a vast array of specialized metabolites that primarily contribute to their defense and survival under adverse conditions....
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Biotechnological approaches for the production of camptothecin
AbstractCamptothecin (CPT), an indole alkaloid popular for its anticancer property, is considered the third most promising drug after taxol and...
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Monoterpene indole alkaloids as leads for targeting multidrug resistant cancer cells from the African medicinal plant Tabernaemontana elegans
Multidrug resistance (MDR) is the main challenge in cancer treatment. Several mechanisms of MDR have been proposed, such as an increased drug efflux...
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Developments in biotechnological tools and techniques for production of reserpine
AbstractIn the quest for novel medications, researchers have kept on studying nature to unearth beneficial plant species with medicinal qualities...
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Single-cell RNA sequencing provides a high-resolution roadmap for understanding the multicellular compartmentation of specialized metabolism
Monoterpenoid indole alkaloids (MIAs) are among the most diverse specialized metabolites in plants and are of great pharmaceutical importance. We...
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Genome-wide survey of the GATA gene family in camptothecin-producing plant Ophiorrhiza pumila
BackgroundOphiorrhiza pumila (Rubiaceae) is capable of producing camptothecin (CPT), one monoterpene indole alkaloid extensively employed in the...
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Crosstalk between melatonin and nitric oxide restrains Cadmium-induced oxidative stress and enhances vinblastine biosynthesis in Catharanthus roseus (L) G Don.
Key messageNitric oxide functions downstream of the melatonin in adjusting Cd-induced osmotic and oxidative stresses, upregulating the transcription...
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Alkaloid Synthesis in In Vitro Cultures of Catharanthus Roseus: Potential and Limitations
Catharanthus roseus (L.) G. Don, Madagascar periwinkle, was among the first plants to be explored for the in vitro production of fine chemicals, due...