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Phytochemistry and Pharmacology of Catharanthus roseus (L.) G. Don and Rauvolfia serpentina (L.) Benth. ex Kurz

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Bioprospecting of Tropical Medicinal Plants

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Abstract

Catharanthus roseus (L.) G.Don and Rauvolfia serpentina (L.) Benth. ex Kurz are well-known medicinal plants belonging to the family Apocynaceae that have been traditionally used as medicine since ancient times and distributed worldwide, especially in Asian and African continents. In the Ayurvedic system of medicine, the plant parts of both these plant species are used in folklore herbal formulations for the treatment of cancer, diabetes, stomach disorders, and cardiovascular diseases. The extracts containing bisindole alkaloids (vinblastine, vincristine, and vindesine) from C. roseus are employed for the treatment of cancer, while various disorders related with the central nervous system (CNS) and cardiovascular diseases (CVD) are treated and managed by the extracts and bioactive monoterpene indole alkaloids (MIAs) (ajmaline, ajmalicine, and reserpine) of R. serpentina. In this communication, we have summarized phytochemistry including biosynthesis of major indole alkaloids and their bioactivities for cancer, CNS, and CVD activities. This has provided a systematic insight into phytochemistry and the therapeutic applications of both the species of C. roseus and R. serpentina.

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Acknowledgments

The authors are thankful to the Principal, MK Govt. Degree College, Ninowa, Farrukhabad, Uttar Pradesh, India, and Director, CSIR-National Botanical Research Institute (NBRI), Lucknow, India for encouragement and facilities.

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  1. Department of Chemistry, Ma. Kanshiram Government Degree College, Ninowa (affiliated to Chhatrapati Shahu Ji Maharaj University (CSJM) Kanpur), Farrukhabad, Uttar Pradesh, India

    Sunil Kumar

  2. Botanic Garden Division, CSIR-National Botanical Research Institute, Rana Pratap Marg, Lucknow, Uttar Pradesh, India

    Bikarma Singh

  3. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

    Bikarma Singh

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Correspondence to Bikarma Singh .

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  1. Center for Studies in Stem Cells Cell Therapy and Toxicological Genetics (CeTroGen), Graduate Program in Health and Development in the Midwest RegionFaculty of Medicine (FAMED)Federal University of Mato Grosso do Sul (UFMS) Campo Grande, Cidade Universitária, Pioneiros, Mato Grosso do Sul, Brazil

    Karuppusamy Arunachalam

  2. Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Kunming, Yunnan, China

    Xuefei Yang

  3. Department of Botany, NSS College Nemmara, Palakkad, Kerala, India

    Sreeja Puthanpura Sasidharan

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Kumar, S., Singh, B. (2023). Phytochemistry and Pharmacology of Catharanthus roseus (L.) G. Don and Rauvolfia serpentina (L.) Benth. ex Kurz. In: Arunachalam, K., Yang, X., Puthanpura Sasidharan, S. (eds) Bioprospecting of Tropical Medicinal Plants. Springer, Cham. https://doi.org/10.1007/978-3-031-28780-0_19

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