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Genes divided according to the relative position of the longest intron show increased representation in different KEGG pathways
Despite the fact that introns mean an energy and time burden for eukaryotic cells, they play an irreplaceable role in the diversification and...
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Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion
RNA-binding proteins (RBPs) modulate alternative splicing outcomes to determine isoform expression and cellular survival. To identify RBPs that...
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Regulation of micro- and small-exon retention and other splicing processes by GRP20 for flower development
Pre-mRNA splicing is crucial for gene expression and depends on the spliceosome and splicing factors. Plant exons have an average size of ~180...
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The exon junction complex is required for DMD gene splicing fidelity and myogenic differentiation
Deposition of the exon junction complex (EJC) upstream of exon-exon junctions helps maintain transcriptome integrity by preventing spurious...
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Comprehensive map** of exon junction complex binding sites reveals universal EJC deposition in Drosophila
BackgroundThe exon junction complex (EJC) is involved in most steps of the mRNA life cycle, ranging from splicing to nonsense-mediated mRNA decay...
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Mutational Bias and Natural Selection Driving the Synonymous Codon Usage of Single-Exon Genes in Rice (Oryza sativa L.)
The relative abundance of single-exon genes (SEGs) in higher plants is perplexing. Uncovering the synonymous codon usage pattern of SEGs will benefit...
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Position-dependent effects of RNA-binding proteins in the context of co-transcriptional splicing
Alternative splicing is an important step in eukaryotic mRNA pre-processing which increases the complexity of gene expression programs, but is...
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Myocardin regulates exon usage in smooth muscle cells through induction of splicing regulatory factors
Differentiation of smooth muscle cells (SMCs) depends on serum response factor (SRF) and its co-activator myocardin ( MYOCD ). The role of MYOCD for...
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Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing
It is estimated that 10%–30% of disease-associated genetic variants affect splicing. Splicing variants may generate deleteriously altered gene...
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Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue
Single-nuclei RNA sequencing characterizes cell types at the gene level. However, compared to single-cell approaches, many single-nuclei cDNAs are...
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Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling
Oncogenic alterations in human epidermal growth factor receptor 2 (HER2) occur in approximately 2% of patients with non-small cell lung cancer and...
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The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity
Huntington’s disease is a neurodegenerative disorder caused by a CAG expansion in the first exon of the HTT gene, resulting in an extended...
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The minimum free energy of G-quadruplex-forming sequences of the MSX1 intron is associated with relative molar and premolar size in eutherians
The mammalian dentition is an important model for studying morphological diversity and evolutionary processes. The main characteristics contributing...
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ExOrthist: a tool to infer exon orthologies at any evolutionary distance
Several bioinformatic tools have been developed for genome-wide identification of orthologous and paralogous genes. However, no corresponding tool...
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Non-invasive and high-throughput interrogation of exon-specific isoform expression
Expression of exon-specific isoforms from alternatively spliced mRNA is a fundamental mechanism that substantially expands the proteome of a cell....
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Conservation of a Chromosome 8 Inversion and Exon Mutations Confirm Common Gulonolactone Oxidase Gene Evolution Among Primates, Including H. Neanderthalensis
Ascorbic acid functions as an antioxidant and facilitates other biochemical processes such as collagen triple helix formation, and iron uptake by...
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Reverse complementary matches simultaneously promote both back-splicing and exon-skip**
BackgroundCircular RNAs (circRNAs) play diverse roles in different biological and physiological environments and are always expressed in a...
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A transient in planta editing assay identifies specific binding of the splicing regulator PTB as a prerequisite for cassette exon inclusion
The dynamic interaction of RNA-binding proteins (RBPs) with their target RNAs contributes to the diversity of ribonucleoprotein (RNP) complexes that...
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The Musashi proteins direct post-transcriptional control of protein expression and alternate exon splicing in vertebrate photoreceptors
The Musashi proteins, MSI1 and MSI2, are conserved RNA binding proteins with a role in the maintenance and renewal of stem cells. Contrasting with...
