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A cilia-bound unconventional secretory pathway for Drosophila odorant receptors
BackgroundPost-translational transport is a vital process which ensures that each protein reaches its site of function. Though most do so via an...
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Characterizing Membrane Traffic in the Early Secretory Pathway Using the RUSH Retention System
The early secretory pathway encompasses the endoplasmic reticulum (ER) and the ER–Golgi intermediate compartment (ERGIC) organelles. The ERGIC is now...
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Regulation of SNARE assembly by protein phosphorylation
Protein phosphorylation is emerging as an important regulatory mechanism that controls the secretory pathway. It enables coupling between the...
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The unfolded protein response unfolds
As a key organelle of protein targeting and secretion, the endoplasmic reticulum (ER) plays host to a wide variety of protein maturation steps...
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ATase inhibition rescues age-associated proteotoxicity of the secretory pathway
Malfunction of autophagy contributes to the progression of many chronic age-associated diseases. As such, improving normal proteostatic mechanisms is...
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Protein networking: nicotinic acetylcholine receptors and their protein–protein-associations
Nicotinic acetylcholine receptors (nAChR) are complex transmembrane proteins involved in neurotransmission in the nervous system and at the...
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Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins
Tyrosinase (TYR) and tyrosinase-related proteins 1 and 2 (TYRP1 and TYRP2) are essential for pigmentation. They are generally classified as type-3...
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Quantification of Protein Exit at the Trans-Golgi Network
With one-third of all newly synthesized proteins entering the secretory pathway, correct protein sorting is essential for cellular homeostasis. In...
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Schistosoma mansoni excretory-secretory products induce protein kinase signalling, hyperkinesia, and stem cell proliferation in the opposite sex
Adult male and female schistosomes in copula dwell within human blood vessels and lay eggs that cause the major Neglected Tropical Disease human...
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A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling
Neudesin, originally identified as a neurotrophic factor, has primarily been studied for its neural functions despite its widespread expression....
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Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection
SidE family of Legionella effectors catalyze non-canonical phosphoribosyl-linked ubiquitination (PR-ubiquitination) of host proteins during bacterial...
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The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21,...
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Exploring the co-operativity of secretory structures for defense and pollination in flowering plants
Main conclusionIn flowers multiple secretory systems cooperate to deliver specialized metabolites to support specific roles in defence and...
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Pathway engineering facilitates efficient protein expression in Pichia pastoris
AbstractPichia pastoris has been recognized as an important platform for the production of various heterologous proteins in recent years. The strong...
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Engineering protein translocation and unfolded protein response enhanced human PH-20 secretion in Pichia pastoris
AbstractHyaluronidases catalyze the degradation of hyaluronan (HA), which is finding rising applications in medicine, cosmetic, and food industries....
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Tardigrade secretory proteins protect biological structures from desiccation
Tardigrades, microscopic animals that survive a broad range of environmental stresses, express a unique set of proteins termed tardigrade-specific...
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NMP4, an Arbiter of Bone Cell Secretory Capacity and Regulator of Skeletal Response to PTH Therapy
The skeleton is a secretory organ, and the goal of some osteoporosis therapies is to maximize bone matrix output. Nmp4 encodes a novel transcription...
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Secretory IgA reduced the ergosterol contents of Candida albicans to repress its hyphal growth and virulence
AbstractCa ndid a albicans , one of the most prevalent conditional pathogenic fungi, can cause local superficial infections and lethal systemic...
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In Silico and In Vitro Analysis of Helicobacter pullorum Type Six Secretory Protein Hcp and Its Role in Bacterial Invasion and Pathogenesis
Helicobacter pullorum is a human zoonotic pathogen transmitted through poultry where it is associated with vibrionic hepatitis and colitis. Hemolysin...
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A Senescence-Associated Secretory Phenotype of Bone Marrow Mesenchymal Stem Cells Inhibits the Viability of Breast Cancer Cells
Breast cancer, the most prevalent malignancy in women, often progresses to bone metastases, especially in older individuals. Dormancy, a critical...
