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P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages
BackgroundThe purinergic receptor P2X7 plays a crucial role in infection, inflammation, and cell death. It is thought that P2X7 receptor stimulation...
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Role of Oxysterols in Ocular Degeneration Mechanisms and Involvement of P2X7 Receptor
Ocular degeneration, including cataracts, glaucoma, macular degeneration, and diabetic retinopathy, is a major public health challenge, as it affects...
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The P2X7 Receptor Methods and Protocols
This detailed volume covers diverse aspects of P2X7 receptor analysis, ranging from its molecular structure to related pharmacological and...
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New mechanistic understanding of osteoclast differentiation and bone resorption mediated by P2X7 receptors and PI3K-Akt-GSK3β signaling
ObjectiveOsteoporosis is a global health issue characterized by decreased bone mass and microstructural degradation, leading to an increased risk of...
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Development of Antibody and Nanobody Tools for P2X7
Antibodies that recognize the ATP-gated P2X7 ion channel are etablished research tools. Nanobodies correspond to the antigen-binding variable...
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Agonists, Antagonists, and Modulators of P2X7 Receptors
The P2X7 receptor has been proposed as a novel drug target for different types of diseases associated with inflammation, including brain diseases,...
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Methods for Studying Cholesterol-Dependent Regulation of P2X7 Receptors
Cholesterol dynamically regulates P2X7 receptor function in both physiological and pathological conditions. Studies suggest that cholesterol...
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Administration of P2X7 Receptor Blockers in Oncological Experimental Models
The tumor microenvironment is rich in components that strongly influence cancer cell survival. One of the pivotal molecules present at the tumor bed...
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ATP-gated P2X7 receptor as a potential target for prostate cancer
Prostate cancer is the most common malignancy of the male genitourinary system and is one of the leading causes of male cancer death. The P2X7...
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Suppression of P2X4 and P2X7 by Lactobacillus rhamnosus vitaP1: effects on hangover symptoms
This study aimed to identify substances including Lactobacillus rhamnosus vitaP1 (KACC 92054P) that alleviate hangover-induced emotional anxiety and...
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Preparation of the Murine Anti-Human P2X7 Receptor Monoclonal Antibody (Clone L4)
The murine anti-human P2X7 receptor monoclonal antibody (mAb) (clone L4) has been used to study the expression and function of the P2X7 receptor on...
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Fully Flexible Ligand Docking for the P2X7 Receptor Using ROSIE
The availability of P2X7 receptor structures with allosteric antagonists bound enables us to predict specific interactions between receptor and...
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Characterization of P2X7 Receptors in Human Blood Cells
P2X7 receptors are expressed in different circulating immune cells. Depending on the cell in which they are expressed, their function could vary from...
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Analyzing the Role of the P2X7 Receptor in Epilepsy
Purinergic signaling is increasingly recognized to play a role during the generation of hyperexcitable networks in the brain. Among the purinergic...
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Immunofluorescence Staining of P2X7 Receptors in Whole-Mount Myenteric Plexus Preparations
P2X7 receptors play an important role in cytokine release and immune cell regulation. Their upregulation has been described in inflammatory and...
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Enhanced Transduction of P2X7-Expressing Cells with Recombinant rAAV Vectors
Adeno-associated viruses (AAV) are useful vectors for transducing cells in vitro and in vivo. Targeting of specific cell subsets with AAV is limited...
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Using Symmetrical Organic Cation Solutions to Study P2X7 Ion Permeation
P2X7 receptors are ATP-gated ion channels permeable to metal cations, such as Na+, K+, and Ca2+. They also exhibit permeability to various large...
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Modulation of Cell Energy Metabolism by the P2X7 Receptor
For many years the P2X7 receptor (P2X7R) was considered the prototypic cytolytic receptor due to its ability to cause dramatic changes in plasma...
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Irradiation causes senescence, ATP release, and P2X7 receptor isoform switch in glioblastoma
Glioblastoma (GBM) is the most lethal brain tumor in adults. Radiation, together with temozolomide is the standard treatment, but nevertheless,...
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Hypoxia‐inducible factor 1 alpha (HIF‐1α) stimulated and P2X7 receptor activated by COVID-19, as a potential therapeutic target and risk factor for epilepsy
Based on available evidence, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a neuroinvasive virus. According to the centers for...
