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Modulation of Cell Energy Metabolism by the P2X7 Receptor

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The P2X7 Receptor

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2510))

Abstract

For many years the P2X7 receptor (P2X7R) was considered the prototypic cytolytic receptor due to its ability to cause dramatic changes in plasma membrane permeability, eventually leading to cell death. However, later studies revealed that controlled P2X7R activation has beneficial effects on cell metabolism and nowadays our perception of the physiological role of this receptor has radically changed. Some of the biochemical pathways underlying the trophic effect of the P2X7R are being unveiled, thus disclosing an unanticipated role of P2X7Rs in mitochondrial and glycolytic metabolism. We provide here an update of the effects of the P2X7R on cell energy metabolism.

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Acknowledgments

This work was supported by the Italian Association for Cancer Research (AIRC) grants No. IG 13025, IG 18581, IG 22883; the Ministry of University and Research of Italy, PRIN 2017 grant No. 8YTNWC, and funds from the University of Ferrara.

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Authors and Affiliations

  1. Department of Medical Sciences, University of Ferrara, Ferrara, Italy

    Francesco Di Virgilio, Simonetta Falzoni, Alba Clara Sarti, Paola Chiozzi, Valentina Vultaggio-Poma & Anna Lisa Giuliani

Authors
  1. Francesco Di Virgilio
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  2. Simonetta Falzoni
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  3. Alba Clara Sarti
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  4. Paola Chiozzi
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  5. Valentina Vultaggio-Poma
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  6. Anna Lisa Giuliani
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Corresponding author

Correspondence to Francesco Di Virgilio .

Editor information

Editors and Affiliations

  1. Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany

    Annette Nicke

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Di Virgilio, F., Falzoni, S., Sarti, A.C., Chiozzi, P., Vultaggio-Poma, V., Giuliani, A.L. (2022). Modulation of Cell Energy Metabolism by the P2X7 Receptor. In: Nicke, A. (eds) The P2X7 Receptor. Methods in Molecular Biology, vol 2510. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2384-8_3

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  • DOI: https://doi.org/10.1007/978-1-0716-2384-8_3

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2383-1

  • Online ISBN: 978-1-0716-2384-8

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