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Data-driven structural analysis of small cell lung cancer transcription factor network suggests potential subtype regulators and transition pathways
Small cell lung cancer (SCLC) is an aggressive disease and challenging to treat due to its mixture of transcriptional subtypes and subtype...
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The global integrative network: integration of signaling and metabolic pathways
The crosstalk between signaling and metabolic pathways has been known to play key roles in human diseases and plant biological processes. The...
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Potential network markers and signaling pathways for B cells of COVID-19 based on single-cell condition-specific networks
To explore the potential network markers and related signaling pathways of human B cells infected by COVID-19, we performed standardized integration...
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Unraveling the anti-breast cancer activity of Cimicifugae rhizoma using biological network pathways and molecular dynamics simulation
Cimicifugae is a commonly used treatment for breast cancer, but the specific molecular mechanisms underlying its effectiveness remain unclear. In...
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On the Realisability of Chemical Pathways
The exploration of pathways and alternative pathways that have a specific function is of interest in numerous chemical contexts. A framework for...
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Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals
The genetic roots of the diverse paces and shapes of ageing and of the large variations in longevity observed across the tree of life are poorly...
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A novel hybrid framework for metabolic pathways prediction based on the graph attention network
BackgroundMaking clear what kinds of metabolic pathways a drug compound involves in can help researchers understand how the drug is absorbed,...
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Identification of levoglucosan degradation pathways in bacteria and sequence similarity network analysis
Levoglucosan is produced in the pyrolysis of cellulose and starch, including from bushfires or the burning of biofuels, and is deposited from the...
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Identification of Key Genes and Pathways for Anaerobic Germination Tolerance in Rice Using Weighted Gene Co-Expression Network Analysis (WGCNA) in Association with Quantitative Trait Locus (QTL) Map**
BackgroundRice is one of the most important food crops in the world, and with the development of direct seeding methods for rice, exposure to...
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Screening of ulcerative colitis biomarkers and potential pathways based on weighted gene co-expression network, machine learning and ceRNA hypothesis
BackgroundUlcerative colitis (UC) refers to an intractable intestinal inflammatory disease. Its increasing incidence rate imposes a huge burden on...
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Intrinsic Signaling Pathways and key Regulatory Factors of Stomatal Development
Stomata are small pores on the surface of plant leaves that play a critical role in regulating gas exchange and water loss. The development of...
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Systems Pharmacology for Immunotherapy: A Network Analysis of Signaling Pathways in Multiple Sclerosis for Combination Therapy Development
Develo** combination therapies aimed to target different biological processes is a sought-after goal for treating complex diseases. However, there...
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Modelling signalling pathways – a yeast approach
MAP kinase pathways are conserved signalling systems in eukaryotes that control stress responses, cell growth, and proliferation, as well as...
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Metabolites of Chemical Signaling Pathways from Crop–Microbe Interactions
Crop–microbe interactions play an important role in plant growth, development, and health. These interactions are mediated by chemical signals, which...
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Prediction of plant secondary metabolic pathways using deep transfer learning
BackgroundPlant secondary metabolites are highly valued for their applications in pharmaceuticals, nutrition, flavors, and aesthetics. It is of great...
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Comparative transcriptome and coexpression network analysis reveals key pathways and hub candidate genes associated with sunflower (Helianthus annuus L.) drought tolerance
BackgroundDrought severely limits sunflower production especially at the seedling stage. To investigate the response mechanism of sunflowers to...
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The interplay between Wnt signaling pathways and microtubule dynamics
Wnt signaling pathways represent an evolutionarily highly conserved, intricate network of molecular interactions that regulates various aspects of...
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Identifying key genes and functionally enriched pathways in acute myeloid leukemia by weighted gene co-expression network analysis
Acute myeloid leukemia (AML) is characterized by the uncontrolled proliferation of myeloid leukemia cells in the bone marrow and other hematopoietic...
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Transcriptome and co-expression network analyses of key genes and pathways associated with differential abscisic acid accumulation during maize seed maturation
BackgroundCurrently, mechanical maize kernel harvesting has not been fully utilized in develo** countries including China, partly due to the...
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Multilayer networks of plasmid genetic similarity reveal potential pathways of gene transmission
Antimicrobial resistance (AMR) is a significant threat to public health. Plasmids are principal vectors of AMR genes, significantly contributing to...
