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Autosis: a new form of cell death in myocardial ischemia–reperfusion injury
Cardiomyocytes undergo a variety of cell death events during myocardial ischemia‒reperfusion injury (MIRI). Understanding the causes of cardiomyocyte...
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PIM3 regulates myocardial ischemia/reperfusion injury via ferroptosis
BackgroundMyocardial ischemia/reperfusion (I/R) injury is closely related with cardiovascular diseases; however, the underlying pathogenic mechanisms...
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PCSK9 regulates myocardial ischemia–reperfusion injury through parkin/pink1-mediated autophagy pathway
ObjectivesThis study aimed at investigating the role of the proprotein convertase subtilisin/Kexin type 9 (PCSK9)-mediated autophagy on myocardial...
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MicroRNA-specific therapeutic targets and biomarkers of apoptosis following myocardial ischemia–reperfusion injury
MicroRNAs are single-stranded non-coding RNAs that participate in post-transcriptional regulation of gene expression, it is involved in the...
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Targeting the Ferroptosis and Endoplasmic Reticulum Stress Signaling Pathways by CBX7 in Myocardial Ischemia/reperfusion Injury
Ferroptosis and endoplasmic reticulum stress (ERS) are common events in the process of myocardial ischemia/reperfusion injury (IRI). The suppression...
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The interplay between T lymphocytes and macrophages in myocardial ischemia/reperfusion injury
Acute myocardial infarction is one of the most important causes of death in the world, causing a huge health and economic burden to the world. It is...
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AMPK, a key molecule regulating aging-related myocardial ischemia-reperfusion injury
Aging leads to the threat of more diseases to the biological anatomical structure and the decline of disease resistance, increasing the incidence and...
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Ubiquitin-specific protease 7 regulates myocardial ischemia/reperfusion injury by stabilizing Keap1
Myocardial ischemia/reperfusion (I/R) injury is a complex pathological process that is still not fully understood. The oxidative stress response has...
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NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis
ObjectivesThe inflammatory cascade and cell death post-myocardial ischemia reperfusion (MI/R) are very complex. Despite the understanding that...
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Inhibition of circ_0073932 attenuates myocardial ischemia‒reperfusion injury via miR-493-3p/FAF1/JNK
Oxidative stress and apoptosis play crucial roles in myocardial ischemia‒reperfusion injury (MIRI). In this study, we investigated the role of...
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Modified APJ Receptor Peptide Ligands as Postconditioning Drugs in Myocardial Ischaemia/Reperfusion Injury
The apelin/APJ system is involved in many physiological functions and pathophysiological effects in cardiovascular diseases, making it a promising...
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Histone modification landscape and the key significance of H3K27me3 in myocardial ischaemia/reperfusion injury
Histone modifications play crucial roles in the pathogenesis of myocardial ischaemia/reperfusion (I/R) injury. However, a genome-wide map of histone...
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Gypenoside A Protects Human Myocardial Cells from Ischemia/Reperfusion Injury via the circ_0010729/miR-370-3p/RUNX1 Axis
AbstractIschemia/reperfusion (I/R) injury is one of the major causes of cardiovascular disease. Gypenoside A (GP), the main active component of Gynost...
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The m6A methylation enzyme METTL14 regulates myocardial ischemia/reperfusion injury through the Akt/mTOR signaling pathway
Herein, we investigated the role of the m 6 A methylation enzyme METTL14 in regulating myocardial ischemia/reperfusion injury (IR/I) through the...
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Myocardial Electrophysiological Response to Ischemia and Reperfusion Depends on the Age of Rats
AbstractAge is a major driver of the risk of acute myocardial infarction and malignant ventricular arrhythmias. However, age-related changes in the...
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STUB1 is acetylated by KAT5 and alleviates myocardial ischemia-reperfusion injury through LATS2-YAP-β-catenin axis
Myocardial ischemia-reperfusion injury (MIRI) is involved in the pathogenesis of multiple cardiovascular diseases. This study elucidated the...
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PPARγ Regulates Macrophage Polarization by Inhibiting the JAK/STAT Pathway and Attenuates Myocardial Ischemia/Reperfusion Injury In Vivo
This study aimed to investigate the role of PPARγ and underlying mechanisms in myocardial ischemia/reperfusion injury (IRI). IRI was surgically...
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MiR-130a-3p regulates FUNDC1-mediated mitophagy by targeting GJA1 in myocardial ischemia/reperfusion injury
Understanding the complex pathogenesis in myocardial ischemia/reperfusion (I/R) injury (IRI) is an urgent problem in clinical trials. Increasing...
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Decreased MFN2 activates the cGAS-STING pathway in diabetic myocardial ischaemia–reperfusion by triggering the release of mitochondrial DNA
BackgroundThe cause of aggravation of diabetic myocardial damage is yet to be elucidated; damage to mitochondrial function has been a longstanding...
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The E3 ubiquitin ligase MARCH2 protects against myocardial ischemia-reperfusion injury through inhibiting pyroptosis via negative regulation of PGAM5/MAVS/NLRP3 axis
Inflammasome activation and pyroptotic cell death are known to contribute to the pathogenesis of cardiovascular diseases, such as myocardial...