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A Mutation in Mediator Subunit MED16A Suppresses Nodulation and Increases Arbuscule Density in Medicago truncatula
Nodulation in legumes is regulated to maintain carbon–nitrogen homeostasis. A systemic negative feedback pathway, Autoregulation of Nodulation (AON)...
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Mutation Work on Other Ornamental Plants
The chapter covers mutation work (mutagens, working dose, mutants) carried out throughout the world on approximately 120 ornamental crops.
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Next Generation Mutation Detection Techniques in Crops
Forward and reverse genetic approaches are powerful ways to understand the genetics of traits of importance and to accelerate crop improvement...
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Mutation Breeding Research in Sweet Pepper
Sweet pepper is delicious, loved, and an increasingly popular nutritional vegetable that is grown and produced in significant amounts throughout the...
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Generation of iPSC lines (KAIMRCi003A, KAIMRCi003B) from a Saudi patient with Dravet syndrome carrying homozygous mutation in the CPLX1 gene and heterozygous mutation in SCN9A
The most prevalent form of epileptic encephalopathy is Dravet syndrome (DRVT), which is triggered by the pathogenic variant SCN1A in 80% of cases....
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Novel Gain-of-Function Mutation in the Kv11.1 Channel Found in the Patient with Brugada Syndrome and Mild QTc Shortening
AbstractBrugada syndrome (BrS) is an inherited disease characterized by right precordial ST-segment elevation in the right precordial leads on...
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Evaluation of Volumetric Bone Mineral Density, Bone Microarchitecture, and Bone Strength in Patients with Achondroplasia Caused by FGFR3 c.1138G > A Mutation
Achondroplasia (ACH) is a skeletal disorder caused by fibroblast growth factor receptor 3 ( FGFR3 ) variants. Volumetric bone mineral density (vBMD),...
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RNA Folding, Mutation, and Detection
The structure of RNA molecules is absolutely critical to their functions in a biological system. RNA structure is dynamic and changes in response to...
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Rapid screening of point mutations by mismatch amplification mutation assay PCR
AbstractMetabolic engineering frequently makes use of point mutation and saturation mutation library creation. At present, sequencing is the only...
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Rapid Cycling and Generation Advancement for Accelerated Mutation Breeding in Sorghum
Rapid cycling techniques have become preferred methods in recent years to speed up the plant breeding process, especially for plant varieties...
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Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers
Mutations in human cells exhibit increased burden in heterochromatic, late DNA replication time (RT) chromosomal domains, with variation in mutation...
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MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC
BackgroundAlthough the clinical application of PARP inhibitors has brought hope to ovarian cancer, the problem of its resistance has become...
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A novel mutation in hERG gene associated with azithromycin-induced acquired long QT syndrome
BackgroundMutations in human ether-à-go-go-related gene (hERG) potassium channels are closely associated with long QT syndrome (LQTS). Previous...
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The COL6A5-p.Glu2272* mutation induces chronic itch in mice
Pruritus is a common irritating sensation that provokes the desire to scratch. Environmental and genetic factors contribute to the onset of pruritus....
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Coupling thermotolerance and high production of recombinant protein by CYR1N1546K mutation via cAMP signaling cascades
In recombinant protein-producing yeast strains, cells experience high production-related stresses similar to high temperatures. It is possible to...
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Mutation Breeding in Date Palm (Phoenix dactylifera L.)
Date palm (Phoenix dactylifera L.) is one of the oldest fruit crops grown in the arid regions of the Arabian Peninsula, North Africa, and the Middle...
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Novel mutation in LRP5 gene cause rare osteosclerosis: cases studies and literature review
To study the effects of low-density lipoprotein receptor-related protein 5 ( LRP5 ) gene mutations on bone, and to open up our view of LRP5 and Wnt...
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Harnessing the potential of mutation breeding, CRISPR genome editing, and beyond for sustainable agriculture
By 2050, the global population is projected to exceed 9.5 billion, posing a formidable challenge to ensure food security worldwide. To address this...
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Genomic dissection and mutation-specific target discovery for breast cancer PIK3CA hotspot mutations
BackgroundRecent advancements in high-throughput genomics and targeted therapies have provided tremendous potential to identify and therapeutically...
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Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation
BackgroundBeyond the observed alterations in cellular structure and mitochondria, the mechanisms linking rare genetic mutations to the development of...
