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MicroRNA let-7d attenuates hypertrophic scar fibrosis through modulation of iron metabolism by reducing DMT1 expression
Hypertrophic scar is an unavoidable result of wound healing following burns and trauma, which remains a challenging problem for clinicians....
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Long non-coding RNA DIO3OS/let-7d/NF-κB2 axis regulates cells proliferation and metastasis of thyroid cancer cells
Due to the steadily rising morbidity and mortality, thyroid cancer remains the most commonly seen endocrine cancer. The present study attempted to...
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MiR-let-7d-3p regulates IL-17 expression through targeting AKT1/mTOR signaling in CD4+ T cells
The aberrant expression of interleukin-17 (IL-17) has been reported in the pathogenesis of autoimmune diseases, such as primary Sjögren’s syndrome...
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Let-7d modulates the proliferation, migration, tubulogenesis of endothelial cells
Endothelial cells are important components of peripheral nerve stumps that contribute to Schwann cell migration and peripheral nerve regeneration....
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Time-resolved Small-RNA Sequencing Identifies MicroRNAs Critical for Formation of Embryonic Stem Cells from the Inner Cell Mass of Mouse Embryos
AbstractCells of the inner cell mass (ICM) acquire a unique ability for unlimited self-renewal during transition into embryonic stem cells (ESCs) in...
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Preliminary study on the effect of nucleolin specific aptamer–miRNA let-7d chimera on Janus kinase-2 expression level and activity in gastric cancer (MKN-45) cells
Recently, much attention has been focused on the use of miRNAs in cancer treatment. The role of proto-oncogene Janus kinase-2 (JAK-2) in...
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Association between Yili goose sperm motility and expression profiles of mRNA and miRNA in testis
BackgroundThe study was conducted to find out the candidate microRNA (miRNA) and genes that associated with sperm motility of Yili goose through...
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Epigenetic Regulators of Inflammatory Gene Expression
Epigenetics is defined as changes in the expression of genes whose core is confined within a non-expressed portion of DNA. All the mechanisms of...
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H19 potentiates let-7 family expression through reducing PTBP1 binding to their precursors in cholestasis
Cholestasis induces the hepatic long non-coding RNA H19, which promotes the progression of cholestatic liver fibrosis. However, microRNAs that are...
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Substrate promiscuity of Dicer toward precursors of the let-7 family and their 3′-end modifications
The human let-7 miRNA family consists of thirteen members that play critical roles in many biological processes, including development timing and...
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Epigenetics of Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal variation of the interstitial pulmonary illness characterised by extracellular matrix deposition that...
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Breaking Barriers: Nucleic Acid Aptamers in Gastrointestinal (GI) Cancers Therapy
Conventional cancer therapies can have significant adverse effects as they are not targeted to cancer cells and may damage healthy cells....
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MicroRNA-124-3p suppresses mouse lip mesenchymal cell proliferation through the regulation of genes associated with cleft lip in the mouse
BackgroundCleft lip (CL), one of the most common congenital birth defects, shows considerable geographic and ethnic variation, with contribution of...
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Regulation of SMAD Signaling Pathway by miRNAs Associated with Myocardial Fibrosis: In silico Analysis of Target Gene Networks
AbstractHypertrophic cardiomyopathy (HCM) is a hereditary heart disease caused by mutations in the sarcomere genes, which is accompanied by...
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MicroRNA-26a in respiratory diseases: mechanisms and therapeutic potential
MicroRNAs (miRNAs) are short, non-coding single-stranded RNA molecules approximately 22 nucleotides in length, intricately involved in...
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MicroRNA let-7 and viral infections: focus on mechanisms of action
MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical cellular processes, a number of which are involved in host...
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Identifying Hmga2 preserving visual function by promoting a shift of Müller glia cell fate in mice with acute retinal injury
BackgroundUnlike in lower vertebrates, Müller glia (MG) in adult mammalian retinas lack the ability to reprogram into neurons after retinal injury or...
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Gametic Embryogenesis in Triticum: a Study of Some Critical Factors in Haploid (Microspore) Embryogenesis
This review of embryogenesis from microspores in two types of wheat examines the influences of various procedures used to induce and produce...
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Changes in Content of Small Noncoding RNA in Spermatozoa as a Possible Mechanism of Transgenerational Transmission of Paternal Stress Effect: An Experimental Study
AbstractIt has been proved that paternal stress can affect the phenotype of offspring, inducing somatic, behavioral, hormonal, and molecular changes....
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KATZNCP: a miRNA–disease association prediction model integrating KATZ algorithm and network consistency projection
BackgroundClinical studies have shown that miRNAs are closely related to human health. The study of potential associations between miRNAs and...
