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Laminin 521 Modulates the Сytotoxic Effect of 5-Fluorouracil on HT29 Colorectal Cancer Cells
AbstractThe cytotoxic effect of 5-fluorouracil (5FU) and regorafenib (RF), drugs with different mechanisms of action used to treat colorectal cancer,...
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Establishing extended pluripotent stem cells from human urine cells
BackgroundExtended pluripotent stem cells (EPSCs) can contribute to both embryonic and trophectoderm-derived extraembryonic tissues. Therefore, EPSCs...
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Generation of proximal tubule-enhanced kidney organoids from human pluripotent stem cells
Kidney organoids derived from human pluripotent stem cells (hPSCs) are now being used as models of renal disease and nephrotoxicity screening....
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Mesenchymal stromal cell-associated migrasomes: a new source of chemoattractant for cells of hematopoietic origin
BackgroundMultipotent mesenchymal stromal cells (MSCs) are precursors of various cell types. Through soluble factors, direct cell–cell interactions...
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Cardiac differentiation of chimpanzee induced pluripotent stem cell lines with different subspecies backgrounds
The comparative analysis between humans and non-human primates is an instrumental approach for elucidating the evolutional traits and disease...
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Bioprinting of human pluripotent stem cell derived corneal endothelial cells with hydrazone crosslinked hyaluronic acid bioink
BackgroundHuman corneal endothelial cells lack regenerative capacity through cell division in vivo . Consequently, in the case of trauma or...
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Preclinical Research of Stem Cells: Challenges and Progress
In recent years, great breakthroughs have been made in basic research and clinical applications of stem cells in regenerative medicine and other...
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Induced Pluripotent Stem Cell-Derived Corneal Cells: Current Status and Application
Deficiency and dysfunction of corneal cells leads to the blindness observed in corneal diseases such as limbal stem cell deficiency (LSCD) and...
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Defective perlecan-associated basement membrane regeneration and altered modulation of transforming growth factor beta in corneal fibrosis
In the cornea, the epithelial basement membrane (EBM) and corneal endothelial Descemet’s basement membrane (DBM) critically regulate the...
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Interplay of the transcription factor MRTF-A and matrix stiffness controls mammary acinar structure and protrusion formation
BackgroundOngoing differentiation processes characterize the mammary gland during sexual development and reproduction. In contrast, defective...
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Measuring Early Germ-Layer Specification Bias in Human Pluripotent Stem Cells
Human pluripotent stem cells have a wide variety of potential applications, ranging from clinical translation to in vitro disease modeling. However,...
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Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) hold great potential in the cardiovascular field for human disease modeling,...
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Biofunctionalised bacterial cellulose scaffold supports the patterning and expansion of human embryonic stem cell-derived dopaminergic progenitor cells
BackgroundStem cell-based therapies for neurodegenerative diseases like Parkinson’s disease are a promising approach in regenerative medicine and are...
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Generation of a bank of clinical-grade, HLA-homozygous iPSC lines with high coverage of the Spanish population
BackgroundInduced pluripotent stem cell (iPSC)-derived cell therapies are an interesting new area in the field of regenerative medicine. One of the...
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Derivation of Multipotent Neural Progenitors from Human Embryonic Stem Cells for Cell Therapy and Biomedical Applications
Long-term neuroepithelial-like stem cells (lt-NES) derived from human embryonic stem cells are a stable self-renewing progenitor population with high...
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Equine Induced Pluripotent Stem Cell Culture
Groundbreaking work by Takahashi and Yamanaka in 2006 demonstrated that non-embryonic cells can be reprogrammed into pluripotent stem cells (PSCs) by...
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Reifung von aus pluripotenten Stammzellen gewonnenen Kardiomyozyten und Zukunftsperspektiven für die regenerative Medizin
Aus pluripotenten Stammzellen gewonnene Kardiomyozyten (PSC-CMs) haben ein großes Potenzial als Quelle für Kardiomyozyten, um abgestorbene Zellen bei...
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Genome Editing Using Cas9-gRNA Ribonucleoprotein in Human Pluripotent Stem Cells for Disease Modeling
The discovery that the CRISPR/Cas9 system could be used for genome editing purposes represented a major breakthrough in the field. This advancement...
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Efficient and safe single-cell cloning of human pluripotent stem cells using the CEPT cocktail
Human pluripotent stem cells (hPSCs) are inherently sensitive cells. Single-cell dissociation and the establishment of clonal cell lines have been...
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Roles for Integrin α3β1 in Development and Disease
Integrins are the major cell surface receptors for adhesion to the extracellular matrix, and their roles in normal physiology and disease pathologies...