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Cellular Distribution Pattern of tjp1 (ZO-1) in Xenopus laevis Oocytes Heterologously Expressing Claudins
Epithelial barriers constitute a fundamental requirement in every organism, as they allow the separation of different environments and set boundaries...
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Roles for Claudins in Regulating Lung Barriers and Function
The lung is a unique barrier forming tissue that has a large surface area exposed to the outside environment and that requires exquisite fluid...
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Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment
Claudins are a 27-member family of ~25 kDa membrane proteins that integrate into tight junctions to form molecular barriers at the paracellular...
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Tight Junctions and Signaling Pathways in Cancer
Tight junctions (TJs) are intercellular connections that close the gap between the individual cells and limit the paracellular entry of harmful...
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Tight Junctions, Epithelial-Mesenchymal Transition, and Cancer Metastasis
Epithelial-mesenchymal transition (EMT) induces dynamic changes in the cellular organization leading to functional changes in cell migration,...
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Non-tight Junction Functions of Claudin Proteins: Roles in Cell-Matrix Interactions and Stem Cell Regulations
Tight junctions (TJs) are the most apical components of the junctional complex in epithelial cells, and they play an essential role in maintaining...
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Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion
Biliary excretion is a major drug elimination pathway that affects their efficacy and safety. The currently available in vitro sandwich-cultured...
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Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice
Claudins are a family of integral tight junction proteins that regulate paracellular permeability in polarized epithelia. Overexpression or reduction...
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Regulation of Tight Junction by Cadherin Adhesion and Its Implication in Inflammation and Cancer
Epithelial cells interact with their cellular microenvironment through the formation of different interactions between the plasma membrane-localized...
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Cellular junction dynamics and Alzheimer’s disease: a comprehensive review
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by progressive neuronal damage and cognitive decline. Recent studies...
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Imaging Techniques to Study Tight Junctions
Tight junctions (TJs) are important regulators of paracellular permeability that act as protective barriers against pathogens and maintain cell...
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The Prophylactic Protection of Salmonella Typhimurium Infection by Lentilactobacillus buchneri GX0328-6 in Mice
Salmonellosis is a disease caused by non-typhoid Salmonella, and although some lactic acid bacteria strains have been shown previously to relieve...
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Intracellular Traffic and Non-canonical Roles of ZO-2 Protein
Zonula occludens 2 (ZO-2) is a peripheral tight junction (TJ) protein of the MAGUK family. This chapter describes how ZO-2 together with ZO-1 forms a...
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Tight Junctions
This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow...
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Claudin1 decrease induced by 1,25-dihydroxy-vitamin D3 potentiates gefitinib resistance therapy through inhibiting AKT activation-mediated cancer stem-like properties in NSCLC cells
Claudins, the integral tight junction proteins that regulate paracellular permeability and cell polarity, are frequently dysregulated in cancer;...
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Tetraspanin Tspan8 restrains interferon signaling to stabilize intestinal epithelium by directing endocytosis of interferon receptor
Inflammation can impair intestinal barrier, while increased epithelial permeability can lead to inflammation. In this study, we found that the...
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Sulforaphane metabolites inhibit migration and invasion via microtubule-mediated Claudins dysfunction or inhibition of autolysosome formation in human non-small cell lung cancer cells
Both sulforaphane-cysteine (SFN-Cys) and sulforaphane- N -acetyl- l -cysteine (SFN-NAC) inhibited cancer migration and invasion, but the underlying...
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Surface layer protein A from hypervirulent Clostridioides difficile ribotypes induce significant changes in the gene expression of tight junctions and inflammatory response in human intestinal epithelial cells
BackgroundSurface layer protein A (SlpA), the primary outermost structure of Clostridioides difficile , plays an essential role in C. difficile ...
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Molecular Architecture and Function of Tight Junctions
Tight junctions, also called zonula occludens, are supramolecular cell–cell adhesion complexes crucial for the architecture of epithelial tissues and...
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The Role of Tight Junction Proteins in Cancer
Tight junctions (TJs) proteins are the network of proteins that play a major role in cell–cell communication and maintaining cell polarity. TJs...