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Retinyl Ester Analysis by Orbitrap Mass Spectrometry
Retinoids are light-sensitive molecules that are normally detected by UV absorption techniques. Here we describe the identification and...
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SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma
Cholesterol metabolism reprogramming is one of the significant characteristics of hepatocellular carcinoma (HCC). Cholesterol increases the risk of...
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High cholesterol intake remodels cholesterol turnover and energy homeostasis in Nile tilapia (Oreochromis niloticus)
The roles of dietary cholesterol in fish physiology are currently contradictory. The issue reflects the limited studies on the metabolic consequences...
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Different Pathways of Cellular Cholesterol Efflux
Cholesterol efflux is the first and rate-limiting step of reverse cholesterol transport (RCT) from peripheric cells to the liver. The involvement of...
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Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis
In cell models, changes in the ‘accessible’ pool of plasma membrane (PM) cholesterol are linked with the regulation of endoplasmic reticulum sterol...
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Pyrophosphorylated-Cholesterol-Modified Bone-Targeting Liposome Formulation Procedure
Bone-targeting drug delivery systems have been rapidly developed to increase drug efficacy and safety for musculoskeletal diseases in the past...
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The Cholesterol-5,6-Epoxide Hydrolase: A Metabolic Checkpoint in Several Diseases
Cholesterol-5,6-epoxides (5,6-ECs) are oxysterols (OS) that have been linked to several pathologies including cancers and neurodegenerative diseases....
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Analysis of Cholesterol Lipids Using Gas Chromatography Mass Spectrometry
An optimized Bligh and Dyer protocol and subsequent derivatization is described in this chapter for the extraction of free cholesterol and...
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An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis
Cholesterol is an essential membrane structural component and steroid hormone precursor, and is involved in numerous signaling processes. Astrocytes...
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Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene
Recent findings have shown that fatty acid metabolism is profoundly involved in ferroptosis. However, the role of cholesterol in this process remains...
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Chromogranin A and its derived peptides: potential regulators of cholesterol homeostasis
Chromogranin A (CHGA), a member of the granin family of proteins, has been an attractive therapeutic target and candidate biomarker for several...
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CD63 sorts cholesterol into endosomes for storage and distribution via exosomes
Extracellular vesicles such as exosomes are now recognized as key players in intercellular communication. Their role is influenced by the specific...
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Tetrahedral Boronate Ester as Regulators of Inflammation and Adhesion in ox-LDL Induced Atherosclerotic Model
AbstractObjective: Boron-based molecules have attracted the attention of researchers in recent years, as they have become one of the largest and...
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Cytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress
Sigma-2-ligands (S2L) are characterized by high binding affinities to their cognate sigma-2 receptor, overexpressed in rapidly proliferating tumor...
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Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate
Hedgehog (Hh) is a morphogen that binds to its receptor Patched 1 and activates Smoothened (SMO), thereby governing embryonic development and...
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Sterols, Phospholipids, and Wax Esters—‘Stay Healthy, Avoid Cholesterol’
Due to beneficial side effects of dietary cholesterol and phytosterols, these lipidic compounds need reconsideration as feedstuff for fishes. Studies...
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Monitoring Atheroprotective Macrophage Cholesterol Efflux In Vivo
This chapter provides details on the methodologies currently used to monitor macrophage cholesterol efflux in vivo in mice. The general principles...
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Correlates of normal and decreased HDL cholesterol levels in type 2 diabetes: a cohort-based cross-sectional study
BackgroundThe literature describes an inverse association between the values of triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C)....
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Mechanisms of Lipoproteins and Reverse Cholesterol Transport in Atherosclerotic Cardiovascular Disease
Coronary heart disease (CHD) makes up approximately 42.1% of all cardiovascular disease deaths in the United States. Cholesterol deposition in the...
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Excessive exogenous cholesterol activating intestinal LXRα-ABCA1/G5/G8 signaling pathway can not reverse atherosclerosis in ApoE−/− mice
BackgroundThe long-term excessive intake of exogenous cholesterol can lead to abnormally elevated blood lipid levels and induce cardiovascular and...
