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ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice
The body temperature of mice is higher at night than during the day. We show here that global deletion of acid-sensing ion channel 1a (ASIC1a)...
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Analysis of residue–residue interactions in the structures of ASIC1a suggests possible gating mechanisms
The gating mechanism of acid-sensitive ion channels (ASICs) remains unclear, despite the availability of atomic-scale structures in various...
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Blockade of ASIC1a inhibits acid-induced rat articular chondrocyte senescence through regulation of autophagy
Acid-sensitive ion channel 1a (ASIC1a), which is abundant in chondrocytes, can sense changes in extracellular acidification. Our previous data...
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Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention
Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is...
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Physiologically relevant acid-sensing ion channel (ASIC) 2a/3 heteromers have a 1:2 stoichiometry
Acid-sensing ion channels (ASICs) sense extracellular protons and are involved in synaptic transmission and pain sensation. ASIC1a and ASIC3 are the...
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Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants
Acid-sensing ion channels (ASICs) are trimeric proton-gated cation channels that play a role in neurotransmission and pain sensation. The snake...
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Acidosis induces RIPK1-dependent death of glioblastoma stem cells via acid-sensing ion channel 1a
Eliciting regulated cell death, like necroptosis, is a potential cancer treatment. However, pathways eliciting necroptosis are poorly understood. It...
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Function and phylogeny support the independent evolution of an ASIC-like Deg/ENaC channel in the Placozoa
ASIC channels are bilaterian proton-gated sodium channels belonging to the large and functionally-diverse Deg/ENaC family that also includes peptide-...
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Anxiolytic Effect of Peptides from Sea Anemone Heteractis crispa, Modulators of TRPV1 and ASIC Channels
AbstractA number of studies confirmed the involvement of transient receptor potential vanilloid (TRPV) and acid-sensing (ASIC) ion channels in the...
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Ligand Docking to the Acidic Pocket of the Proton-Gated Ion Channel Asic1A
AbstractIn this study, we performed the docking of ligands of the ASIC1a ion channel, which exert potentiating or inhibitory effects by stabilizing...
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Physiological Functions of Acid-Sensing Ion Channels (ASICS) in the Brain
AbstractThe proton-gated ion channels of the ASIC family have been intensively studied over the last two decades. Despite the great progress achieved...
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Role of NLRP3 Inflammasome in Pathogenesis of Ischemic Stroke
AbstractIschemic stroke (IS) is a prevalent condition worldwide with high mortality and disability risks. The issue of its pathogenetic therapy...
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Mechanism and role of nuclear laminin B1 in cell senescence and malignant tumors
Nuclear lamin B1 (LMNB1) is a member of the nuclear lamin protein family. LMNB1 can maintain and ensure the stability of nuclear structure and...
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Nocistatin and Products of Its Proteolysis Are Dual Modulators of Type 3 Acid-Sensing Ion Channels (ASIC3) with Algesic and Analgesic Properties
AbstractThe neuropeptide nocistatin (NS) is expressed by the nervous system cells and neutrophils as a part of a precursor protein and can undergo...
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Exploring oak processionary caterpillar induced lepidopterism (part 2): ex vivo bio-assays unmask the role of TRPV1
As human skin comes into contact with the tiny hairs or setae of the oak processionary caterpillar, Thaumetopoea processionea , a silent yet intense...
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RNA methylations in hepatic fibrosis, a gradually emerging new treatment strategy
BackgroundHepatic fibrosis (HF) is a pathological process caused by excessive accumulation of extracellular matrix caused by a series of causes,...
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Insight into the pathophysiological advances and molecular mechanisms underlying cerebral stroke: current status
Molecular pathways involved in cerebral stroke are diverse. The major pathophysiological events that are observed in stroke comprises of...
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Mechanisms of the Acidosis Effect on Vascular Tone
AbstractThe activity of many physiological mechanisms depends on pH; therefore, maintaining a normal pH in the body is one of the important tasks of...
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The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases
Pyroptosis is a controlled form of inflammatory cell death characterized by inflammasome activation, pore formation, and cell lysis. According to...
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Cryo-EM structure of the ASIC1a–mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect
Acid-sensing ion channels (ASICs) are neuronal voltage-independent Na + channels that are activated by extracellular acidification. ASICs play...
