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Variations of intronic branchpoint motif: identification and functional implications in splicing and disease
The branchpoint (BP) motif is an essential intronic element for spliceosomal pre-mRNA splicing. In mammals, its sequence composition, distance to the...
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Untangling the Evolution of the Receptor-Binding Motif of SARS-CoV-2
The spike protein determines the host-range specificity of coronaviruses. In particular, the Receptor-Binding Motif in the spike protein from...
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Probable human origin of the SARS-CoV-2 polybasic furin cleavage motif
BackgroundThe key evolutionary step leading to the pandemic virus was the acquisition of the PRRA furin cleavage motif at the spike glycoprotein...
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vamos: variable-number tandem repeats annotation using efficient motif sets
Roughly 3% of the human genome is composed of variable-number tandem repeats (VNTRs): arrays of motifs at least six bases. These loci are highly...
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Protein–Protein Interfaces as Druggable Targets: A Common Motif of the Pyridoxal-5′-Phosphate-Dependent Enzymes to Receive the Coenzyme from Its Producers
AbstractPyridoxal-5′-phosphate (PLP), a phosphorylated form of vitamin B6, acts as a coenzyme for numerous reactions, including those changed in...
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Prediction of motif-mediated viral mimicry through the integration of host–pathogen interactions
One of the mechanisms viruses use in hijacking host cellular machinery is mimicking Short Linear Motifs (SLiMs) in host proteins to maintain their...
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Genome-wide analysis of lectins in cyanobacteria: from evolutionary mode to motif patterns
Lectins are glycoproteins that can bind to specific carbohydrates, and different lectin families exhibit different biological activities. They are...
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Positional motif analysis reveals the extent of specificity of protein-RNA interactions observed by CLIP
BackgroundCrosslinking and immunoprecipitation (CLIP) is a method used to identify in vivo RNA–protein binding sites on a transcriptome-wide scale....
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Biophysical characterization of the DNA binding motif of human phospholipid scramblase 1
Human phospholipid scramblase 1 (hPLSCR1) is a 37 kDa multi-compartmental protein, which was initially identified as a Ca 2+ -dependent phospholipid...
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Chemerin attracts neutrophil reverse migration by interacting with C–C motif chemokine receptor-like 2
Neutrophil reverse migration (rM) is a recently identified phenomenon in which neutrophils migrate away from the inflammatory site back into the...
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ImitateDB: A database for domain and motif mimicry incorporating host and pathogen protein interactions
Molecular mimicry of host proteins by pathogens constitutes a strategy to hijack the host pathways. At present, there is no dedicated resource for...
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LBD18 and IAA14 antagonistically interact with ARF7 via the invariant Lys and acidic residues of the OPCA motif in the PB1 domain
Main conclusionLBD18 and IAA14 antagonistically interact with ARF7 through the electrostatic faces in the ARF7PB1 domain, modulating ARF7...
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Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron
Studying the antibody response to SARS-CoV-2 informs on how the human immune system can respond to antigenic variants as well as other SARS-related...
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Relating spidroin motif prevalence and periodicity to the mechanical properties of major ampullate spider silks
Spider dragline fibers exhibit incredible mechanical properties, outperforming many synthetic polymers in toughness assays, and possess desirable...
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An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking
β-Coronaviruses such as SARS-CoV-2 hijack coatomer protein-I (COPI) for spike protein retrograde trafficking to the progeny assembly site in...
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C-C motif chemokine receptor 2 and 7 synergistically control inflammatory monocyte recruitment but the infecting virus dictates monocyte function in the brain
Inflammatory monocytes (iMO) are recruited from the bone marrow to the brain during viral encephalitis. C-C motif chemokine receptor (CCR) 2...
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Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal Stability to the Serotonin1A Receptor
G protein-coupled receptors (GPCRs) constitute the largest class of membrane proteins that transduce signals across the plasma membrane and...
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A two-sequence motif-based method for the inventory of gene families in fragmented and poorly annotated genome sequences
Databases of genome sequences are growing exponentially, but, in some cases, assembly is incomplete and genes are poorly annotated. For evolutionary...
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Features and Functions of the A-Minor Motif, the Most Common Motif in RNA Structure
AbstractA-minor motifs are RNA tertiary structure motifs that generally involve a canonical base pair and an adenine base forming hydrogen bonds with...
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Tetramic acid-motif natural products from a marine fungus Tolypocladium cylindrosporum FB06 and their anti-Parkinson activities
Tetramic acid-containing natural products are attracting significantly increasing attention from biologists and chemists due to their intriguing...
