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Genomic Resources for Disease Resistance in Watermelon
Watermelon (Citrullus lanatus) (2n = 22) is one of the economically important fresh fruits, widely consumed, with the fruit being almost free from...
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Detection and treatment of Alzheimer’s disease in its preclinical stage
Longitudinal multimodal biomarker studies reveal that the continuum of Alzheimer’s disease (AD) includes a long latent phase, referred to as...
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Systemic screening of Fusarium oxysporum candidate effectors reveals FoSSP17 that suppresses plant immunity and contributes to virulence
Fusarium oxysporum f. sp. cubense ( Foc ) causes Fusarium wilt of banana ( Musa spp.), a notorious soil-borne vascular fungal disease threatening the...
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Artificial intelligence assisted identification of potential tau aggregation inhibitors: ligand- and structure-based virtual screening, in silico ADME, and molecular dynamics study
Alzheimer’s disease (AD) is a severe, growing, multifactorial disorder affecting millions of people worldwide characterized by cognitive decline and...
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Efficient Screening Techniques to Identify Mutants with TR4 Resistance in Banana Protocols
Bananas are a staple food for over 500 million people and are also an important cash crop. Fusarium wilt, caused by the fungus Fusarium oxysporum...
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Screening diverse wheat (Triticum aestivum L.) genotypes for spot blotch resistance
South Asian countries like India face various challenges for wheat ( Triticum aestivum L.) production including spot blotch caused by Bipolaris...
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Accessing Transient Binding Pockets by Protein Engineering and Yeast Surface Display Screening
The binding pocket of some therapeutic targets can acquire multiple conformations that, to some extent, depend on the protein dynamics and the...
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Molecular characterization of phytoplasma strains associated with brinjal little leaf and screening of cultivated and wild relatives of eggplant cultivars for disease resistance
Brinjal little leaf (BLL) is one of the most important and widespread disease of eggplant associated with a phytoplasma in India. It severely infects...
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Comprehensive analysis of little leaf disease incidence and resistance in eggplant
BackgroundLittle leaf disease caused by phytoplasma infection is a significant threat to eggplant (also known as brinjal) cultivation in India. This...
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Proof-of-principle study using Saccharomyces cerevisiae for universal screening test for cancer through ultrasound-based size distinction of circulating tumor cell clusters
Screening strategies for cancer, the second largest cause of deaths, exist, but are invasive, cumbersome, and expensive. Many cancers lack viable...
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Mutation screening in autosomal dominant congenital cataract families from North India
Congenital cataract an opacity of the eye lens is present at birth and results in visual impairment during early childhood. If left untreated, it can...
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Screening and identification of DNA nucleic acid aptamers against F1 protein of Yersinia pestis using SELEX method
BackgroundYersinia pestis is a bacterium that causes the disease plague. It has caused the deaths of many people throughout history. The bacterium...
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The potential molecular markers of inflammatory response in KOA with AD based on single-cell transcriptome sequencing analysis and identification of ligands by virtual screening
Alzheimer's disease (AD) and osteoarthritis (OA) are both senile degenerative diseases. Clinical studies have found that OA patients have a...
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Non-radioactive Rb+ Efflux Assay for Screening KATP Channel Modulators
ATP-sensitive potassium (KATP) channels function as metabolic sensors that link cell membrane excitability to the cellular energy status by...
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Development of antibody to virulence factor flagellin and its evaluation in screening Ralstonia pseudosolanacearum
The bacterial wilt disease caused by Ralstonia pseudosolanacearum presents a notable economic risk to a variety of crucial crops worldwide. During...
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PICLS with human cells is the first high throughput screening method for identifying novel compounds that extend lifespan
Gerontology research on anti-aging interventions with drugs could be an answer to age-related diseases, aiming at closing the gap between lifespan...
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CRISPR-Based Screening in Three-Dimensional Organoid Cultures to Identify TGF-β Pathway Regulators
The CRISPR/Cas technology has revolutionized forward genetic screening, and thereby facilitated genetic dissection of cellular processes and...
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Population WGS-based spinal muscular atrophy carrier screening in a cohort of 1076 healthy Polish individuals
Spinal muscular atrophy is a severe neuromuscular disorder with an autosomal recessive inheritance pattern. The disease-causing gene is SMN1 , and its...
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Screening for agroactive and bioactive metabolites production by actinobacteria isolated from rhizospheric soils
In this study, agroactive and bioactive compound production by actinobacteria isolated from rhizospheres of different plants was screened. Six of the...
