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Syringaresinol protects against diabetic nephropathy by inhibiting pyroptosis via NRF2-mediated antioxidant pathway
Diabetic nephropathy (DN) is one of the serious complications of diabetes that has limited treatment options. As a lytic inflammatory cell death,...
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Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis
Platelets have emerged as key inflammatory cells implicated in the pathology of sepsis, but their contributions to rapid clinical deterioration and...
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Oxygen-Dependent Adaptation Processes in a Human Organism in Normal Living Conditions and during Space Flight
AbstractThe review examines various parties of oxygen-dependent human adaptation to microgravity belonging to different levels of the integral system...
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LPS-related muscle loss is associated with the alteration of Bacteroidetes abundance, systemic inflammation, and mitochondrial morphology in a weaned piglet model
We previously demonstrated that lipopolysaccharide (LPS) injection-induced immune stress could impair muscle growth in weaned piglets, but the...
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Decreased MFN2 activates the cGAS-STING pathway in diabetic myocardial ischaemia–reperfusion by triggering the release of mitochondrial DNA
BackgroundThe cause of aggravation of diabetic myocardial damage is yet to be elucidated; damage to mitochondrial function has been a longstanding...
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Acetate attenuates hyperoxaluria-induced kidney injury by inhibiting macrophage infiltration via the miR-493-3p/MIF axis
Hyperoxaluria is well known to cause renal injury and end-stage kidney disease. Previous studies suggested that acetate treatment may improve the...
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Dysregulated expression of microRNAs acts as prognostic and diagnostic biomarkers for glioma patients
IntroductionMicroRNAs are regulatory non-coding RNAs, with their outstanding regulatory mechanism, that make them potential biomarker for disease...
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Dusp26 phosphatase regulates mitochondrial respiration and oxidative stress and protects neuronal cell death
The dual specificity protein phosphatases (Dusps) control dephosphorylation of mitogen-activated protein kinases (MAPKs) as well as other substrates....
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MSC-Derived Exosomes Ameliorate Intervertebral Disc Degeneration By Regulating the Keap1/Nrf2 Axis
Bone marrow mesenchymal stem cell derived exosomes (BMSC-exos) are a crucial means of intercellular communication and can regulate a range of...
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Alamandine alleviates hypertension and renal damage via oxidative-stress attenuation in Dahl rats
Alamandine (Ala) is a novel member of the renin–angiotensin-system (RAS) family. The present study aimed to explore the effects of Ala on...
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α-KG inhibits tumor growth of diffuse large B-cell lymphoma by inducing ROS and TP53-mediated ferroptosis
Metabolic reprogramming is a hallmark of human malignancies. Dysregulation of glutamine metabolism is essential for tumorigenesis, microenvironment...
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Inflammaging in domestic dogs: basal level concentrations of IL-6, IL-1β, and TNF-α in serum of healthy dogs of different body sizes and ages
Inflammaging, a “hallmark of aging,” refers to a chronic, progressive increase in the proinflammatory status of mammals as they age, and this...
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Alamandine alleviated heart failure and fibrosis in myocardial infarction mice
Alamandine (Ala) is the newest identified peptide of the renin-angiotensin system and has protective effect on myocyte hypertrophy. However, it is...
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Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population
BackgroundHepatic lipase (HL, encoded by LIPC ) is a glycoprotein primarily synthesized and secreted by hepatocytes. Previous studies had...
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Evaluation of urinary 8-hydroxy-2-deoxyguanosine level in experimental Alzheimer’s disease: Impact of carvacrol nanoparticles
The present study aimed to compare the effect of carvacrol essential oil and carvacrol nanoemulsion against experimental Alzheimer’s (AD). Forty male...
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Contribution of SOS genes to H2O2-induced apoptosis-like death in Escherichia coli
Hydrogen peroxide (H 2 O 2 ) is a debriding agent that damages the microbial structure and function by generating various reactive oxygen species (ROS). H
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SIRT6 regulates obesity-induced oxidative stress via ENDOG/SOD2 signaling in the heart
The sirtuin 6 (SIRT6) participates in regulating glucose and lipid homeostasis. However, the function of SIRT6 in the process of cardiac pathogenesis...
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Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer
Ferroptosis, a form of programed cell death, can be promoted by inhibitors of the xCT transporter (erastin) or GPX4 (RSL3). We found that GPX4, but...
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Review of Zinc Oxide Nanoparticles: Toxicokinetics, Tissue Distribution for Various Exposure Routes, Toxicological Effects, Toxicity Mechanism in Mammals, and an Approach for Toxicity Reduction
Zinc oxide (ZnO) nanoparticles (NPs) are widely used as a sunscreen, antibacterial agent, dietary supplement, food additive, and semiconductor...
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The Protective Effects of Taurine, a Non-essential Amino Acid, Against Metals Toxicities: A Review Article
Taurine is a non-proteinogenic amino acid derived from cysteine. It is involved in several phenomena such as the regulation of growth and...
