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A Detached Leaf Assay for Rapidly Screening Plant Pathogen-Biological Control Agents
The detached leaf assay (DLA) is a nondestructive method for evaluating interactions between plants and disease-causing agents that allows quick...
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Genome-wide screening reveals the genetic basis of mammalian embryonic eye development
BackgroundMicrophthalmia, anophthalmia, and coloboma (MAC) spectrum disease encompasses a group of eye malformations which play a role in childhood...
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Promoting Alzheimer’s disease research and therapy with stem cell technology
BackgroundAlzheimer’s disease (AD) is a prevalent form of dementia leading to memory loss, reduced cognitive and linguistic abilities, and decreased...
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Application of three-dimensional cell culture technology in screening anticancer drugs
The drug development process involves a variety of drug activity evaluations, which can determine drug efficacy, strictly analyze the biological...
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Screening of Yardlong bean (Vigna unguiculata (L.) Walp.ssp. unguiculata cv.-gr. sesquipedalis) genotypes for seed, yield and disease resistance traits
Yardlong bean genotypes have wide variability in seed coat colours. This study sought to screen of yardlong bean genotypes based on seed coat colour,...
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3D QSAR based Virtual Screening of Flavonoids as Acetylcholinesterase Inhibitors
In an attempt to develop therapeutic agents to treat Alzheimer’s disease, a series of flavonoid analogues were collected, which already had...
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Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening
Investigating how chromatin organization determines cell-type-specific gene expression remains challenging. Experimental methods for measuring...
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Rapid screening of point mutations by mismatch amplification mutation assay PCR
AbstractMetabolic engineering frequently makes use of point mutation and saturation mutation library creation. At present, sequencing is the only...
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Computational discovery of AKT serine/threonine kinase 1 inhibitors through shape screening for rheumatoid arthritis intervention
Rheumatoid Arthritis (RA) is a chronic, symmetrical inflammatory autoimmune disorder characterized by painful, swollen synovitis and joint erosions,...
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Screening of Key Genes in Retinoblastoma and Construction of ceRNA Regulatory Network
Retinoblastoma (RB) is an intraocular malignancy with a high incidence and very severe symptoms in children and is a rare life-threatening ophthalmic...
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Screening wild Brassica species against Alternaria brassicicola (Schw.) Wiltsh for breeding Alternaria leaf spot resistance in Brassica vegetables
Alternaria leaf spot is a major disease of Brassica crops, and it causes huge economic loss to both the cultivated Brassica oilseeds and vegetables....
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A Robust Phenotypic Screening Assay Utilizing Human Podocytes to Identify Agents that Modulate Lipid Droplets
Lipid droplets (LDs), initially thought to be mere lipid storage structures, are highly dynamic organelles with complex functions that control cell...
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Computational screening of potential drugs against COVID-19 disease: the Neuropilin-1 receptor as molecular target
The transmembrane receptor Neuropilin-1 (NRP-1) was reported to serve as a host cell entry factor for the severe acute respiratory syndrome...
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Identification of novel inhibitors for mycobacterial polyketide synthase 13 via in silico drug screening assisted by the parallel compound screening with genetic algorithm-based programs
Identifying small compounds capable of inhibiting Mycobacterium tuberculosis polyketide synthase 13 (Pks13), in charge of final step of mycolic acid...
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siRNA screening reveals that SNAP29 contributes to exosome release
Cells release extracellular vesicles (EVs) of different sizes. Small EVs (< 200 nm) can originate from the fusion of multivesicular bodies with the...
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Targeted screening and identification of chlorhexidine as a pro-myogenic circadian clock activator
BackgroundThe circadian clock is an evolutionarily conserved mechanism that exerts pervasive temporal control in stem cell behavior. This...
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Resistance to stem rot disease in groundnut (Arachis hypogaea L.) in inter-specific derivatives of wild Arachis species
Stem rot of groundnut, caused by a necrotrophic pathogen Sclerotium rolfsii Sacc., is an important soil-borne disease that can cause a pod yield loss...
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PHDs-seq: a large-scale phenotypic screening method for drug discovery through parallel multi-readout quantification
High-throughput phenotypic screening is a cornerstone of drug development and the main technical approach for stem cell research. However,...
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Association between the non-HDL-cholesterol to HDL- cholesterol ratio and abdominal aortic aneurysm from a Chinese screening program
BackgroundAbdominal aortic aneurysms (AAAs) can result in high mortality upon rupture but are usually undiagnosed because of the absence of symptoms...
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Novel in silico screening system for plant defense activators using deep learning-based prediction of reactive oxygen species accumulation
BackgroundPlant defense activators offer advantages over pesticides by avoiding the emergence of drug-resistant pathogens. However, only a limited...
