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Assessment of Developmental Neurotoxicity Using Semi-automatic Behavior Analysis System for Zebrafish
Traditionally, morphological, conventional, and toxicological approaches have been used to demonstrate neurotoxicity; however, there has been a...
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A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits
Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how the...
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Anti-Hebbian plasticity drives sequence learning in striatum
Spatio-temporal activity patterns have been observed in a variety of brain areas in spontaneous activity, prior to or during action, or in response...
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Origin of acetylcholine antagonism in ELIC, a bacterial pentameric ligand-gated ion channel
ELIC is a prokaryotic homopentameric ligand-gated ion channel that is homologous to vertebrate nicotinic acetylcholine receptors. Acetylcholine binds...
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Voltage Clamp Fluorometry: Illuminating the Dynamics of Ion Channels
Ion channels comprise one of the largest targets for drug development and treatment and have been a subject of enduring fascination since first...
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Structure and Functions of Gap Junctions and Their Constituent Connexins in the Mammalian CNS
Abstract —Numerous data obtained in the last 20 years indicate that all parts of the mature central nervous system, from the retina and olfactory bulb...
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Adam, amigo, brain, and K channel
Voltage-dependent K + (Kv) channels are diverse, comprising the classical Shab − Kv2, Shaker − Kv1, Shal − Kv4, and Shaw − Kv3 families. The Shaker ...
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Astrocytic NMDA Receptors
AbstractAstrocytic NMDA receptors (NMDARs) are heterotetramers, whose expression and properties are largely determined by their subunit composition....
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L-Carnosine Dipeptide (β-Alanyl-L-Histidine): Cryoprotector of Nervous Tissue of Nonhibernating Animals
Abstract—In this work the cryoprotective properties of the dipeptide L -carnosine (β-alanyl- L -histidine) on slices of the rat brain olfactory cortex...
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Bioelectric networks: the cognitive glue enabling evolutionary scaling from physiology to mind
Each of us made the remarkable journey from mere matter to mind: starting life as a quiescent oocyte (“just chemistry and physics”), and slowly,...
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Pheromone sensing in Drosophila requires support cell-expressed Osiris 8
BackgroundThe nose of most animals comprises multiple sensory subsystems, which are defined by the expression of different olfactory receptor...
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Architecture of the human NALCN channelosome
NALCN regulates the resting membrane potential by mediating the Na + leak current in neurons, and it functions as a channelosome in complex with...
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Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
Complex formation between hexokinase-II (HKII) and the mitochondrial VDAC1 is crucial to cell growth and survival. We hypothesize that HKII first...
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Treadmill exercise modulates the medial prefrontal-amygdala neural circuit to improve the resilience against chronic restraint stress
Aerobic exercise effectively ameliorates mental disorders including anxiety and depression. Current findings mainly attribute its neural mechanism to...
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Channelrhodopsins: From Phototaxis to Optogenetics
AbstractChannelrhodopsins stand out among other retinal proteins because of their capacity to generate passive ionic currents following...
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Functional correlates of clinical phenotype and severity in recurrent SCN2A variants
In SCN2A- related disorders, there is an urgent demand to establish efficient methods for determining the gain- (GoF) or loss-of-function (LoF)...
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Intracranial electroencephalography reveals effector-independent evidence accumulation dynamics in multiple human brain regions
Neural representations of perceptual decision formation that are abstracted from specific motor requirements have previously been identified in...
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3D-printed nerve guidance conduits multi-functionalized with canine multipotent mesenchymal stromal cells promote neuroregeneration after sciatic nerve injury in rats
BackgroundNerve injuries are debilitating, leading to long-term motor deficits. Remyelination and axonal growth are supported and enhanced by growth...
