Ranolazine is an anti-arrhythmic drug that targets voltage-gated sodium channels. Lenaeus et al. present a cryo-EM structure of the cardiac sodium channel bound to ranolazine to demonstrate that this compound acts as a structural clamp that inhibits the channels.
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References
Abriel, H. J. Mol. Cell Cardiol. 48, 2–11 (2010).
Clancy, C. E. et al. J. Physiol. 593, 1331–1345 (2015).
Roden, D. M. Card. Electrophysiol. Clin. 6, 695–704 (2014).
Ragsdale, D. S. et al. Science 265, 1724–1728 (1994).
Horvath, B. et al. Front. Pharmacol. 11, 413 (2020).
Li, Z. et al. Angew. Chem. Int. Ed. Engl. 60, 11474–11480 (2021).
Jiang, D. et al. Cell 180, 122–134 (2019).
Lenaeus, M. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-023-00271-5 (2023).
Fuller, H. et al. Heart Rhythm 13, 1679–1686 (2016).
Chakouri, N. et al. Nat. Cardiovasc. Res. 1, 1–13 (2022).
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Fossier, L., Ben-Johny, M. New insights on cardiac Na channel block by an atypical anti-arrhythmic drug. Nat Cardiovasc Res 2, 494–495 (2023). https://doi.org/10.1038/s44161-023-00284-0
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DOI: https://doi.org/10.1038/s44161-023-00284-0
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