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Three-Dimension Co-culture of Hematopoietic Stem Cells and Differentiated Osteoblasts on Gallic Acid Grafted-Chitosan Scaffold as a Model of Hematopoietic Stem Cells Niche
The existing approaches of hematopoietic stem cells (HSCs) expansion in vitro were difficult to meet the needs of clinical application. While in...
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Design, synthesis and mechanism study of novel natural-derived isoquinoline derivatives as antifungal agents
In screening for natural fungicidal leads, two series of novel 3-aryl-isoquinoline derivatives 8 and 9 were designed and synthesized based on...
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Nanoparticles in Biosensor Design for the Agrifood Sector
In the last years, there was an increasing demand for portable, affordable, and effective diagnostics for the agrifood sector. Advances in...
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Combination of Filtered Bone Marrow Aspirate and Biomimetic Scaffold for the Treatment of Knee Osteochondral Lesions: Cellular and Early Clinical Results of a Single Centre Case Series
Background:Osteochondral injury is a very common orthopaedic pathology, mainly affecting young, active population, with limited current treatment...
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Multimodal probing of T-cell recognition with hexapod heterostructures
Studies using antigen-presenting systems at the single-cell and ensemble levels can provide complementary insights into T-cell signaling and...
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Stem Cell Bioreactors: Design, Structure, and Operation of Stem Cell Bioreactors
A bioreactor is a manufactured device or system that helps to produce biologically active substances such as yeast, bacteria, or mammalian cells...
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The Effect of the Mechanical Properties of the 3D Printed Gelatin/Hyaluronic Acid Scaffolds on hMSCs Differentiation Towards Chondrogenesis
Background:Tissue engineering, including 3D bioprinting, holds great promise as a therapeutic tool for repairing cartilage defects. Mesenchymal stem...
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Model organisms and systems in neuroethology: one hundred years of history and a look into the future
The Journal of Comparative Physiology lived up to its name in the last 100 years by including more than 1500 different taxa in almost 10,000...
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Review: Human stem cell-based 3D in vitro angiogenesis models for preclinical drug screening applications
Vascular diseases are the underlying pathology in many life-threatening illnesses. Human cellular and molecular mechanisms involved in angiogenesis...
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Design and Fabrication of Biological Wires for Cardiac Fibrosis Disease Modeling
Extensive progress has been made in develo** engineered models for elucidating human cardiac disease. Cardiac fibrosis is often associated with all...
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Emergence in Biomimetic Materials Systems
The importance of emergent characteristics in the knowledge transfer from biological role models to biomimetic materials systems is discussed. After...
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Peculiarities of meroterpenoids and their bioproduction
AbstractMeroterpenoids are a class of terpenoid-containing hybrid natural products with impressive structural architectures and remarkable...
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Biomimetic smoking robot for in vitro inhalation exposure compatible with microfluidic organ chips
Exposure of lung tissues to cigarette smoke is a major cause of human disease and death worldwide. Unfortunately, adequate model systems that can...
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Recombinant expression a novel fibronectin—collage fusion peptide modulating stem cell stemness via integrin β3
AbstractConstructing bionic extracellular matrix (ECM) is an attractive proposition for tissue engineering and clinical regeneration therapy...
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High-Throughput Assembly of Compositionally Controlled 3D Cell Communities for Developmental Engineering
Cell patterning for 3D culture has increased our understanding of how cells interact among themselves and with their environment during tissue...
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RETRACTED ARTICLE: A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function
Overcoming tumor-mediated immunosuppression and enhancing cytotoxic T-cell activity within the tumor microenvironment are two central...
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Chemical Basis of Carbon Fixation Autotrophic Paleometabolism
AbstractOn the basis of biomimetic, phylometabolic, and thermodynamic analysis of modern CO 2 assimilation pathways, a paleophenotypic reconstruction...
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Advances in Regenerative Medicine and Biomaterials
The low regenerative potential of the human body hinders proper regeneration of dysfunctional or lost tissues and organs due to trauma, congenital...