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PLAUR splicing pattern in hereditary angioedema patients’ monocytes and macrophages
BackgroundThe PLAUR gene encodes the urokinase-like plasminogen activator receptor (uPAR) and may undergo alternative splicing. Excluding cassette...
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Myocardin regulates exon usage in smooth muscle cells through induction of splicing regulatory factors
Differentiation of smooth muscle cells (SMCs) depends on serum response factor (SRF) and its co-activator myocardin ( MYOCD ). The role of MYOCD for...
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Revealing diverse alternative splicing variants of the highly homologous SMN1 and SMN2 genes by targeted long-read sequencing
The survival of motor neuron ( SMN ) genes, SMN1 and SMN2 , are two highly homologous genes related to spinal muscular atrophy (SMA). Different patterns...
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Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells
Dysregulation of anti-apoptotic and pro-apoptotic protein isoforms arising from aberrant splicing is a crucial hallmark of cancers and may contribute...
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Plant Intron-Splicing Efficiency Database (PISE): exploring splicing of ∼1,650,000 introns in Arabidopsis, maize, rice, and soybean from ∼57,000 public RNA-seq libraries
Intron retention is the most common alternative splicing event in plants and plays a crucial role in the responses of plants to environmental...
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SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1
Dysregulation of serine/arginine splicing factors (SRSFs) and abnormal alternative splicing (AS) have been widely implicated in various cancers but...
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Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis
Most mammalian genes generate messenger RNAs with variable untranslated regions (UTRs) that are important post-transcriptional regulators. In cancer,...
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RNA-seq Analysis Reveals Alternative Splicing Under Heat Stress in Rainbow Trout (Oncorhynchus mykiss)
Rainbow trout ( Oncorhynchus mykiss ) is one of the most economically important cold-water farmed species in the world, and transcriptomic studies in...
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Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing
It is estimated that 10%–30% of disease-associated genetic variants affect splicing. Splicing variants may generate deleteriously altered gene...
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Alternative Splicing of Titin mRNA in Rat Soleus after Seven-Day Gravitational Unloading
AbstractChanges in titin alternative splicing in the rat soleus after seven-day gravitational unloading (the hindlimb unloading model) were studied...
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Intronic small nucleolar RNAs regulate host gene splicing through base pairing with their adjacent intronic sequences
BackgroundSmall nucleolar RNAs (snoRNAs) are abundant noncoding RNAs best known for their involvement in ribosomal RNA maturation. In mammals, most...
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Position-dependent effects of RNA-binding proteins in the context of co-transcriptional splicing
Alternative splicing is an important step in eukaryotic mRNA pre-processing which increases the complexity of gene expression programs, but is...
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Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer’s disease
BackgroundMolecular characterization of late-onset Alzheimer’s disease (LOAD), the leading cause of age-related dementia, has revealed transcripts,...
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The Arabidopsis spliceosomal protein SmEb modulates ABA responses by maintaining proper alternative splicing of HAB1
Abscisic acid (ABA) signaling is critical for seed germination and abiotic stress responses in terrestrial plants. Pre-mRNA splicing is known to...
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Analysis of Alternative Splicing and Long Noncoding RNAs After the Edwardsiella anguillarum Infected the Immunized European Eels (Anguilla anguilla) Revealed the Role of Outer Membrane Protein A in OmpA Subunit Vaccine
Edwardsiella anguillarum is a bacterium that commonly infects cultivated eels. Outer membrane protein A (OmpA) emulsified with Freund’s adjuvant has...
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Regulation of micro- and small-exon retention and other splicing processes by GRP20 for flower development
Pre-mRNA splicing is crucial for gene expression and depends on the spliceosome and splicing factors. Plant exons have an average size of ~180...
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Exon-1 skip** and intron-1 retaining by alternative splicing of the c-KIT gene encodes a novel splice variant in the skin of Merino sheep (Ovis aries)
c -KIT , a type III receptor protein tyrosine kinase , plays an essential role in melanocyte development, migration, and survival. Mutations within the c
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The exon junction complex is required for DMD gene splicing fidelity and myogenic differentiation
Deposition of the exon junction complex (EJC) upstream of exon-exon junctions helps maintain transcriptome integrity by preventing spurious...
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Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing
Sequence-specific RNA-binding proteins (RBPs) play central roles in splicing decisions. Here, we describe a modular splicing architecture that...
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Long noncoding RNA DGCR5 involves in tumorigenesis of esophageal squamous cell carcinoma via SRSF1-mediated alternative splicing of Mcl-1
Long noncoding RNAs (lncRNAs) emerge as essential roles in the regulation of alternative splicing (AS) in various malignancies. Serine- and...
