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Crosstalk of cell death pathways unveils an autophagy-related gene AOC3 as a critical prognostic marker in colorectal cancer
The intricate crosstalk of various cell death forms was recently implicated in cancers, laying a foundation for exploring the association between...
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Signaling Pathways in Plant Responses to Abiotic Stress
Recent scientific advancements have significantly improved our understanding of plant signaling pathways under abiotic stress. However, further...
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Discrete Logic Modeling of Cell Signaling Pathways
Cell signaling pathways often crosstalk generating complex biological behaviors observed in different cellular contexts. Frequently, laboratory...
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Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder
Classical metabolomic and new metabolic network methods were used to study the developmental features of autism spectrum disorder (ASD) in newborns ( n ...
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Imprints of indirect interactions on a resource-mediated ant–plant network across different levels of network organization
Indirect interactions are pivotal in the evolution of interacting species and the assembly of populations and communities. Nevertheless, despite...
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Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells
Epithelial–mesenchymal transition (EMT) is a cell remodeling process in which epithelial cells undergo a reversible phenotype switch via the loss of...
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Extreme environmental adaptation mechanisms of Antarctic bryophytes are mainly the activation of antioxidants, secondary metabolites and photosynthetic pathways
The environment in Antarctica is characterized by low temperature, intense UVB and few vegetation types. The Pohlia nutans M211 are bryophytes, which...
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Pathways for Agroecological Transitions
Agroecological transitions entail a reconfiguration of the social and ecological dimensions of agroecosystems to produce and sustain rural...
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EmbryoNet: using deep learning to link embryonic phenotypes to signaling pathways
Evolutionarily conserved signaling pathways are essential for early embryogenesis, and reducing or abolishing their activity leads to characteristic...
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Signaling Pathways Regulating Cartilage Formation
Over the course of many years of investigation, the molecular processes that regulate the differentiation of chondrocytes throughout the development...
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Elevated expression of ISY1, APOA-1, SYNE1, MTG1, and MMP10 at HCC initiation: HCC specific protein network involving interactions of key regulators of lipid metabolism, EGFR signaling, MAPK, and splicing pathways
Identification of molecular regulators of hepatocellular carcinoma (HCC) initiation and progression is not well understood. We chemically induced HCC...
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Co-expression analysis reveals distinct alliances around two carbon fixation pathways in hydrothermal vent symbionts
Most autotrophic organisms possess a single carbon fixation pathway. The chemoautotrophic symbionts of the hydrothermal vent tubeworm Riftia pachyptila ...
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Network-based drug repurposing identifies small molecule drugs as immune checkpoint inhibitors for endometrial cancer
Endometrial cancer (EC) is the 6th most common cancer in women around the world. Alone in the United States (US), 66,200 new cases and 13,030 deaths...
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Identification of common genetic factors and immune-related pathways associating more than two autoimmune disorders: implications on risk, diagnosis, and treatment
Autoimmune disorders (ADs) are chronic conditions resulting from failure or breakdown of immunological tolerance, resulting in the host immune system...
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Stages of preadipocyte differentiation: biomarkers and pathways for extracellular structural remodeling
BackgroundThis study utilized bioinformatics to analyze the underlying biological mechanisms involved in adipogenic differentiation, synthesis of the...
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Evaluation of network-guided random forest for disease gene discovery
BackgroundGene network information is believed to be beneficial for disease module and pathway identification, but has not been explicitly utilized...
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Executable models of immune signaling pathways in HIV-associated atherosclerosis
Atherosclerosis (AS)-associated cardiovascular disease is an important cause of mortality in an aging population of people living with HIV (PLWH)....
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Identifying driver pathways based on a parameter-free model and a partheno-genetic algorithm
BackgroundTremendous amounts of omics data accumulated have made it possible to identify cancer driver pathways through computational methods, which...
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Network pharmacological analysis and experimental study of cucurbitacin B in oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a malignant tumor with a high incidence and poor prognosis. Cucurbitacin B (CuB) is a tetracyclic triterpenoid...
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Deciphering neuroprotective mechanism of nitroxoline in cerebral ischemia: network pharmacology and molecular modeling-based investigations
Cerebral ischemia is one of the major causes of death and disability worldwide. Currently, existing approved therapies are based on reperfusion and...
