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Bioactive peptides from fermented foods and their relevance in COVID-19 mitigation
Bioactive peptides are unique, low molecular weight peptide sequences generally consisting of 2–20 amino acid residues. These peptide sequences are...
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In vitro enzyme inhibitory effects of green and brown Australian seaweeds and potential impact on metabolic syndrome
Hypertension, type-2-diabetes (T2D) and obesity are contributory risk factors for the development of metabolic syndrome. Peptides, polyphenols and...
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A potent virucidal activity of functionalized TiO2 nanoparticles adsorbed with flavonoids against SARS-CoV-2
AbstractThe coronavirus SARS-CoV-2 has caused a pandemic with > 550 millions of cases and > 6 millions of deaths worldwide. Medical management of...
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Sex-specific cardiovascular remodeling leads to a divergent sex-dependent development of heart failure in aged hypertensive rats
IntroductionThe prevalence of heart failure with preserved ejection fraction (HFpEF) is continuously rising and predominantly affects older women...
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Impact of elevated CO2 on yield, nutritional and medicinal properties of Corchorus olitorius
Human activities like burning fossil fuels and destroying forests have greatly boosted atmospheric carbon dioxide (CO 2) . Scientists have linked this...
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In Silico Evaluation of Promising Naturally Occurring Bioactive Ligands Against Molecular Targets of SARS-Cov-2
The fatal virus SARS-CoV-2 emerged in December 2019, which caused a global pandemic of coronavirus disease, also known as COVID-19. Identification of...
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Repurposing of RAS-Pathway Mediated Drugs for Intestinal Inflammation Related Diseases for Treating SARS-CoV-2 Infection
Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is an emerging zoonotic virus, which causes Coronavirus Disease 2019 (COVID-19). Entry...
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Thermodynamically coupled biosensors for detecting neutralizing antibodies against SARS-CoV-2 variants
We designed a protein biosensor that uses thermodynamic coupling for sensitive and rapid detection of neutralizing antibodies against severe acute...
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Genetic variation of pharmacogenomic VIP variants in the Chinese Li population: an updated research
Previous studies have shown that the frequency of very important pharmacogenomic (VIP) genes varies in different populations which leads to the...
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Damage to the Vascular Endothelium as a Leading Mechanism of COVID-19 Systemic Pathology
An analysis of the molecular and pathophysiological mechanisms of COVID-19 is presented. The endothelium of blood vessels, a kind of “endocrine tree”...
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Molecular surveillance revealed no SARS-CoV-2 spillovers to raccoons (Procyon lotor) in four German federal states
Raccoons ( Procyon lotor ), which are closely related to the family Mustelidae, might be susceptible to natural infection by SARS-CoV-2. This...
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Cyanometabolites: molecules with immense antiviral potential
Cyanometabolites are active compounds derived from cyanobacteria that include small low molecular weight peptides, oligosaccharides, lectins,...
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A protective erythropoietin evolutionary landscape, NLRP3 inflammasome regulation, and multisystem inflammatory syndrome in children
The low incidence of pediatric severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and the associated multisystem inflammatory...
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In silico and in vitro assessment of bioactive peptides from Arthrospira platensis phycobiliproteins for DPP-IV inhibitory activity, ACE inhibitory activity, and antioxidant activity
Arthrospira platensis proteins are considered as viable ingredients for functional foods with nutraceutical properties and health-promoting effects....
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Bioinformatics analysis reveals molecular connections between non-alcoholic fatty liver disease (NAFLD) and COVID-19
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has devastatingly impacted people’s lives. Non-alcoholic fatty liver...
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Evaluating the effects of sodium glucose co-transporter -2 inhibitors from a renin–angiotensin–aldosterone system perspective in patients infected with COVID-19: contextualizing findings from the dapagliflozin in respiratory failure in patients with COVID-19 study
Numerous studies demonstrate parallels between CVD, type 2 diabetes mellitus (T2DM) and COVID-19 pathology, which accentuate pre-existing...
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Synthesis of biologically active cefpodoxime and vanillin-based schiff base metal complexes with the detailed biological evaluations
Schiff bases of existing antimicrobial drugs are an area, which is still to be comprehensively explored to improve drug efficiency against...
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Bisulfite-Free Sequencing of 5-Hydroxymethylcytosine with APOBEC-Coupled Epigenetic Sequencing (ACE-Seq)
Here, we provide a detailed protocol for our previously published technique, APOBEC-Coupled Epigenetic Sequencing (ACE-Seq)APOBEC-coupled epigenetic...
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The Variations of Microbial Diversity and Community Structure Along Different Stream Orders in Wuyi Mountains
The surface water is an important habitat for freshwater microorganisms, but there is a lack of understanding of the pattern of microbial diversity...
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SARS CoV-2 spike protein variants exploit DC-SIGN/DC-SIGNR receptor for evolution and severity: an in-silico insight
The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is related with the COVID-19 pandemic. Recent spike protein variations have had an...
