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Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge
The EMDataResource Ligand Model Challenge aimed to assess the reliability and reproducibility of modeling ligands bound to protein and...
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Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling and cloud-native open-source tools
Contemporary pose estimation methods enable precise measurements of behavior via supervised deep learning with hand-labeled video frames. Although...
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Non-destructive wood identification using X-ray µCT scanning: which resolution do we need?
BackgroundTaxonomic identification of wood specimens provides vital information for a wide variety of academic (e.g. paleoecology, cultural heritage...
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Combining the fractional order derivative and machine learning for leaf water content estimation of spring wheat using hyper-spectral indices
Leaf water content (LWC) is a vital indicator of crop growth and development. While visible and near-infrared (VIS–NIR) spectroscopy makes it...
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A versatile tissue-rolling technique for spatial-omics analyses of the entire murine gastrointestinal tract
Tissues are dynamic and complex biological systems composed of specialized cell types that interact with each other for proper biological function....
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Deciphering spatial domains from spatial multi-omics with SpatialGlue
Advances in spatial omics technologies now allow multiple types of data to be acquired from the same tissue slice. To realize the full potential of...
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Field cabbage detection and positioning system based on improved YOLOv8n
BackgroundPesticide efficacy directly affects crop yield and quality, making targeted spraying a more environmentally friendly and effective method...
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Low-cost and reliable substrate-based phenoty** platform for screening salt tolerance of cutting propagation-dependent grass, paspalum vaginatum
BackgroundSalt tolerance in plants is defined as their ability to grow and complete their life cycle under saline conditions. Staple crops have...
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Map** and quantifying unique branching structures in lentil (Lens culinaris Medik.)
BackgroundLentil ( Lens culinaris Medik.) is a globally-significant agricultural crop used to feed millions of people. Lentils have been cultivated...
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High-throughput volumetric map** of synaptic transmission
Volumetric imaging of synaptic transmission in vivo requires high spatial and high temporal resolution. Sha** the wavefront of two-photon...
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Permittivity tensor imaging: modular label-free imaging of 3D dry mass and 3D orientation at high resolution
The dry mass and the orientation of biomolecules can be imaged without a label by measuring their permittivity tensor (PT), which describes how...
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Quantifying cell-state densities in single-cell phenotypic landscapes using Mellon
Cell-state density characterizes the distribution of cells along phenotypic landscapes and is crucial for unraveling the mechanisms that drive...
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DNA simulation benchmarks revealed with the accumulation of high-resolution structures
DNA carries more than the list of biochemical instructions that drive the basic functions of living systems. The sequence of base pairs includes a...
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Electro-elution-based purification of covalent DNA–protein cross-links
Covalent DNA–protein cross-links (DPCs) are pervasive DNA lesions that challenge genome stability and can be induced by metabolic or chemotherapeutic...
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Assessing RNA atomistic force fields via energy landscape explorations in implicit solvent
Predicting the structure and dynamics of RNA molecules still proves challenging because of the relative scarcity of experimental RNA structures on...
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High-throughput single-cell transcriptomics of bacteria using combinatorial barcoding
Microbial split-pool ligation transcriptomics (microSPLiT) is a high-throughput single-cell RNA sequencing method for bacteria. With four...
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The HADDOCK2.4 web server for integrative modeling of biomolecular complexes
Interactions between macromolecules, such as proteins and nucleic acids, are essential for cellular functions. Experimental methods can fail to...
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Quantifying DNA replication speeds in single cells by scEdU-seq
In a human cell, thousands of replication forks simultaneously coordinate duplication of the entire genome. The rate at which this process occurs...
