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Tumour-associated and non-tumour-associated bacteria co-abundance groups in colorectal cancer
Background & aimsGut microbiota is closely related to the occurrence and development of colorectal cancer (CRC). However, the differences in...
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How the Ecology of Calcified Red Macroalgae is Investigated under a Chemical Approach? A Systematic Review and Bibliometric Study
Characteristics such as calcareous morphology and life cycle are used to understand the ecology of calcified rhodophytes. However, there is limited...
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Gapr for large-scale collaborative single-neuron reconstruction
Whole-brain analysis of single-neuron morphology is crucial for unraveling the complex structure of the brain. However, large-scale neuron...
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Gut microbiota Parabacteroides distasonis enchances the efficacy of immunotherapy for bladder cancer by activating anti-tumor immune responses
ObjectiveBladder cancer(BCa) was a disease that seriously affects patients’ quality of life and prognosis. To address this issue, many researches...
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Impact of captivity and natural habitats on gut microbiome in Epinephelus akaara across seasons
BackgroundThe gut microbiota significantly influences the health and growth of red-spotted grouper ( Epinephelus akaara ), a well-known commercial...
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Biofilm-producing ability of methicillin-resistant Staphylococcus aureus clinically isolated in China
BackgroundStaphylococcus aureus , a commensal bacterium, colonizes the skin and mucous membranes of approximately 30% of the human population. Apart...
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Formic acid sandwich method is well-suited for filamentous fungi identification and improves turn around time using Zybio EXS2600 mass spectrometry
ObjectivesMatrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is extensively employed for the identification...
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CRISPR-Cas3 and type I restriction-modification team up against blaKPC-IncF plasmid transfer in Klebsiella pneumoniae
ObjectiveWe explored whether the Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas and restriction-modification (R-M) systems are...
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cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers
The canonical BRG/BRM-associated factor (cBAF) complex is essential for chromatin opening at enhancers in mammalian cells. However, the nature of the...
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Structural basis of MALAT1 RNA maturation and mascRNA biogenesis
The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) long noncoding RNA (lncRNA) has key roles in regulating transcription, splicing,...
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fENko-Kae01 is a flagellum-specific jumbo phage infecting Klebsiella aerogenes
BackgroundKlebsiella aerogenes is an opportunistic pathogen that causes a wide variety of infections. Due to the rising problem of antibiotic...
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Single-base tiled screen unveils design principles of PspCas13b for potent and off-target-free RNA silencing
The development of precise RNA-editing tools is essential for the advancement of RNA therapeutics. CRISPR (clustered regularly interspaced short...
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Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly
The mitochondrial chaperonin, mitochondrial heat shock protein 60 (mtHsp60), promotes the folding of newly imported and transiently misfolded...
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Predicting glycan structure from tandem mass spectrometry via deep learning
Glycans constitute the most complicated post-translational modification, modulating protein activity in health and disease. However, structural...
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Alterations of the bile microbiome is associated with progression-free survival in pancreatic ductal adenocarcinoma patients
BackgroundPatients with pancreatic ductal adenocarcinoma (PDAC) display an altered oral, gastrointestinal, and intra-pancreatic microbiome compared...
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Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy
During formation of the transcription-competent open complex (RPo) by bacterial RNA polymerases (RNAPs), transient intermediates pile up before...
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Lipopeptides from Bacillus velezensis ZLP-101 and their mode of action against bean aphids Acyrthosiphon pisum Harris
BackgroundNatural products are important sources for the discovery of new biopesticides to control the worldwide destructive pests Acyrthosiphon...
