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Epigenetics in Oral Health
An individual’s oral health over their lifetime is governed by a complex and dynamic interplay between their environment and their genetics,...
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Embryologic Development of the Jaws
The development of the jaws influences the face, the periodontium, the teeth, and the airway. It is important that one understands the development of...
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Epigenetics in the Oral Cavity
Epigenetics consider the interface between genetics and environmental factors. Epigenetic modifications include chemical alterations of DNA and...
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Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1
Osteoarthritis (OA) is a prevalent joint disease with no effective treatment strategies. Aberrant mechanical stimuli was demonstrated to be an...
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Heritability of maxillary dental cephalometric variables among monozygotic twins, dizygotic twins and their siblings
ObjectivesThe purpose of this study was to investigate the heritability of dental cephalometric variables by analyzing vertical linear measurements...
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Epigenetics and Periodontitis: A Source of Connection to Systemic Diseases
Over the past 15 years, there has been intense research interest in periodontitis and its associations with several systemic conditions and how...
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Effects of post-COVID-19 vaccination in oral cavity: a systematic review
ObjectivesSARS-CoV-2 virus and its variants continue to be on a rampage worldwide. Several vaccines are being marketed to control their spread and...
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Genetic and Developmental Pathology
A genetic disorder is a disease caused in whole or in part by a change in the DNA sequence away from the normal sequence. These are categorised as...
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Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation
Several chronic disorders including type 2 diabetes (T2D), obesity, heart disease and cancer are preceded by a state of chronic low-grade...
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Demographics, smoking status, and systemic health factors associated with apical periodontitis in a Brazilian rural population: a cross-sectional study
ObjectiveTo determine whether the systemic diseases diabetes mellitus (DM) and arterial hypertension (AH), and smoking status are associated with...
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Isolated dentinogenesis imperfecta: Novel DSPP variants and insights on genetic counselling
ObjectiveDentinogenesis imperfecta (DI) is an inherited dentin defect and may be isolated or associated with disorders such as osteogenesis...
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Patient Assessment
Though the ideal position of the central incisor has not been clearly identified in dental literature for esthetics, function, and airway, several...
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Increased SEC14L2 expression is associated with clinicopathological features and worse prognosis in oral squamous cell carcinoma
Abnormal expression of SEC14L2 has been implicated in many human cancers. However, the role of SEC14L2 in oral squamous cell carcinoma (OSCC) remains...
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Aberrated PSMA1 expression associated with clinicopathological features and prognosis in oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a globally prevalent cancer with significant mortality rates. OSCC a predominant subtype of head and neck...
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Compound heterozygous WNT10A missense variations exacerbated the tooth agenesis caused by hypohidrotic ectodermal dysplasia
BackgroundThe aim of this study was to analyse the differences in the phenotypes of missing teeth between a pair of brothers with hypohidrotic...
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Global perspectives in orofacial cleft management and research
Orofacial clefts (OFCs) refer to clefts of the lip and palate, a heterogeneous group of relatively common congenital conditions that can cause...
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TUSC3, p53 and p21 genetic association with development of oral submucous fibrosis and oral squamous cell carcinoma among addictive tobacco chewers of Pakistan
BackgroundThis study delves into the intricate landscape of oral cancer, a global concern with a high incidence in Asian countries. We focus on oral...
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Molar-incisor hypomineralisation prevalence in a cohort of Australian children with type 1 diabetes
PurposeSystemic diseases or drugs administered early in life may cause a disruption in amelogenesis and contribute to the qualitative defect of...
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Salivary level of microRNA-146a and microRNA-155 biomarkers in patients with oral lichen planus versus oral squamous cell carcinoma
BackgroundOral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa, which has potential for malignant transformation. MicroRNAs...
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Maternal depression in first 1000 days of life and early childhood caries prevalence at 48 months of age
ObjectivesThe aim of this study was to investigate the effect of maternal’s depression trajectory in the first 1000 days of the child’s life on the...
