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Synthesis of Pregnane–Cholesterol and Cholesterol–Cholesterol Prodrugs via Ring A–Ring A Connection. Potential Cytotoxic Activity against Cervical Cancer Cell Line HeLa
AbstractTwo novel pregnane–cholesterol and cholesterol–cholesterol prodrugs have been synthesized. The synthetic route involved preparation of...
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Alterations in Cholesterol and Phosphoinositides Levels in the Intracellular Cholesterol Trafficking Disorder NPC
Lipid mistrafficking is a biochemical hallmark of Niemann-Pick Type C (NPC) disease and is classically characterized with endo/lysosomal accumulation... -
Intracellular cholesterol efflux effects of mannose-beta cyclodextrin conjugates on cholesterol-laden foam cells
Lipid-laden foam cells within the arterial walls play a key role in the development of atherosclerotic lesions at early disease stages, and they have...
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Direct Method for Simultaneous Analysis of Cholesterol and Cholesterol Oxides by HPLC in Meat and Meat Products
Cholesterol and cholesterol oxides have numerous implications for human health, highlighting the importance of determining these compounds in highly... -
Cholesterol and PIP2 Modulation of BKCa Channels
Ca2+/voltage-gated, large conductance K+ channels (BKCa) are formed by homotetrameric association of α (slo1) subunits. Their activity, however, is... -
Cholesterol
The cholesterol determination in meat and meat products is very important because these products are highly demanded. The intake of high levels of... -
Cholesterol and PI(4,5)P2 in Vital Biological Functions From Coexistence to Crosstalk
Cholesterol is an essential component of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), although a minor phospholipid, is...
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Cholesterol and Phosphoinositides in Cilia Biology
Cilia are evolutionarily conserved organelles that can be found on virtually every cell. They appear as hair-like structures emanating from the... -
PI(4,5)P2 and Cholesterol: Synthesis, Regulation, and Functions
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is the most abundant membrane phosphoinositide and cholesterol is an essential component of the... -
Facile immobilization of cholesterol oxidase on Pt,Ru–C nanocomposite and ionic liquid–modified carbon paste electrode for an efficient amperometric free cholesterol biosensing
In present work, the enzyme cholesterol oxidase (ChOx) was immobilized by Nafion® (Naf) on Pt,Ru–C nanocomposite and an ionic liquid (IL) – modified...
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Lactiplantibacillus plantarum PGB02 Improved Serum Cholesterol Profile by Tweaking Genes Involved in Cholesterol Homeostasis in Male Swiss Albino Mice
The effect of Lactiplantibacillus plantarum PGB02 isolated from buttermilk on serum cholesterol profile of normal and hypercholesterolemic mice was...
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Antioxidant and cholesterol regulatory effect of flavonoid-rich silk sericin
Cholesterol is a component of cell membranes and a precursor of hormones, and excess levels are associated with disease development; therefore, it...
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Decrease of cholesterol content in cereal products containing animal-based components
The daily intake of excessive cholesterol plays an important role in the incidence of cardiovascular diseases (CVD), while the main contributors are...
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Phenylalanine functionalized cryogels for selective cholesterol removal from milk
High cholesterol grades are a significant threat factor for coronary heart disease, which leads to heart attacks. General practices focus on lowering...
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Regulation of ThermoTRP Channels by PIP2 and Cholesterol
Transient receptor potential (TRP) ion channels are proteins that are expressed by diverse tissues and that play pivotal functions in physiology.... -
Enzyme sensor for simultaneous determination of cholesterol, triglyceride and HDL cholesterol in serum
A three-electrode lipid biosensor that simultaneously measures the total cholesterol (CHO), triglyceride (TG), and HDL cholesterol (HDL-C) in...
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Analysis of Cholesterol from the Liver Using Gas Chromatography–Mass Spectrometry
Cholesterol is an essential lipid molecule for several biological functions including the proper functioning of cell membranes, lipoproteins, and... -
Crosstalk Between Cholesterol, ABC Transporters, and PIP2 in Inflammation and Atherosclerosis
The lowering of plasma low-density lipoprotein cholesterol (LDL-C) is an easily achievable and highly reliable modifiable risk factor for preventing... -
Analysis of cholesterol-recognition motifs of the plasma membrane Ca2+-ATPase
The plasma membrane Ca 2+ -ATPase (PMCA) is crucial for the fine tuning of intracellular calcium levels in eukaryotic cells. In this study, we show the...
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Highly sensitive electrochemical detection of cholesterol based on Au–Pt NPs/PAMAM–ZIF-67 nanomaterials
A cholesterol biosensor was constructed by bimetallic (Au and Pt) and poly(amidoamine)-zeolite imidazole framework (PAMAM–ZIF-67). First,...