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Regulation of ThermoTRP Channels by PIP2 and Cholesterol

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Cholesterol and PI(4,5)P2 in Vital Biological Functions

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1422))

Abstract

Transient receptor potential (TRP) ion channels are proteins that are expressed by diverse tissues and that play pivotal functions in physiology. These channels are polymodal and are activated by several stimuli. Among TRPs, some members of this family of channels respond to changes in ambient temperature and are known as thermoTRPs. These proteins respond to heat or cold in the noxious range and some of them to temperatures considered innocuous, as well as to mechanical, osmotic, and/or chemical stimuli. In addition to this already complex ability to respond to different signals, the activity of these ion channels can be fine-tuned by lipids. Two lipids well known to modulate ion channel activity are phosphatidylinositol 4,5-bisphosphate (PIP2) and cholesterol. These lipids can either influence the function of these proteins through direct interaction by binding to a site in the structure of the ion channel or through indirect mechanisms, which can include modifying membrane properties, such as curvature and rigidity, by regulating their expression or by modulating the actions of other molecules or signaling pathways that affect the physiology of ion channels. Here, we summarize the key aspects of the regulation of thermoTRP channels by PIP2 and cholesterol.

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Acknowledgments

We thank Itzel Llorente for the preparation of figures and proofreading the manuscript. This work was supported by grants Dirección General de Asuntos del Personal Académico (DGAPA)-Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica (PAPIIT) grant IN200720, Consejo Nacional de Ciencia y Tecnología (CONACyT) grant A1-S-8760, and Secretaría de Educación, Ciencia, Tecnología e Innovación del Gobierno de la Ciudad de México grant SECTEI/208/2019 to T.R and PAPIIT-IN206819 and FORDECYT-PRONACES (FORDECYT-PRONACES/64392/2020), CONACyT to S.L.M.-L.

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  1. Departamento de Neurociencia Cognitiva, División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, Mexico

    Tamara Rosenbaum & Sara L. Morales-Lázaro

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Correspondence to Tamara Rosenbaum .

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  1. Department of Chemistry, University of Illinois Chicago, Chicago, IL, USA

    Avia Rosenhouse- Dantsker

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Rosenbaum, T., Morales-Lázaro, S.L. (2023). Regulation of ThermoTRP Channels by PIP2 and Cholesterol. In: Dantsker, A.R. (eds) Cholesterol and PI(4,5)P2 in Vital Biological Functions. Advances in Experimental Medicine and Biology, vol 1422. Springer, Cham. https://doi.org/10.1007/978-3-031-21547-6_9

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