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Modeling of Quantum Yields, Structure and Function of Cytochrome C and Cardiolipin: Its Enzymatic Activity and Free Radical Processes
AbstractQuantum yields, structure, and enzymatic activity points of coumarin–activated C-334 chemiluminescence of lipid peroxidation processes under...
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Lack of activation of the S113L variant of carnitine palmitoyltransfersase II by cardiolipin
The phospholipid environment of the mitochondrial inner membrane, which contains large amounts of cardiolipin, could play a key role in transport of...
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Characterization of oxidation of glutathione by cytochrome c
Cytochrome c is a member of the respiratory chain of the mitochondria. Non-membrane-bound (free) cytochrome c can be reduced by gluthatione as well...
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Regulatory effect of peroxiredoxin 1 (PRDX1) on doxorubicin-induced apoptosis in triple negative breast cancer cells
Patients with triple negative breast cancer (TNBC) lack the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2;...
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Analysis of lipid composition and characterization of acyl steryl glycosides in rose petals by using nontargeted LC/MS
Edible roses are rich in bioactive metabolites including lipids and they are widely used in food and traditional medicine. The phytochemicals present...
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Structural characterization of phospholipids and sphingolipids by in-source fragmentation MALDI/TOF mass spectrometry
Phospholipids (PLs) and sphingolipids (SLs) perform critical structural and biological functions in cells. The structure of these lipids, including...
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Lipid membrane remodeling and metabolic response during isobutanol and ethanol exposure in Zymomonas mobilis
BackgroundRecent engineering efforts have targeted the ethanologenic bacterium Zymomonas mobilis for isobutanol production. However, significant...
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The evolution of the human mitochondrial bc1 complex- adaptation for reduced rate of superoxide production?
The mitochondrial bc1 complex is a major source of mitochondrial superoxide. While bc1-generated superoxide plays a beneficial signaling role, excess...
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Transcending membrane barriers: advances in membrane engineering to enhance the production capacity of microbial cell factories
Microbial cell factories serve as pivotal platforms for the production of high-value natural products, which tend to accumulate on the cell membrane...
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Formation of intracellular vesicles within the Gram+ Lactococcus lactis induced by the overexpression of Caveolin-1β
BackgroundCaveolae are invaginated plasma membrane domains of 50–100 nm in diameter involved in many important physiological functions in eukaryotic...
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Lipidomics Analysis of Different Marine Fish Oils Using Untargeted Liquid Chromatography–Orbitrap High-Resolution Mass Spectrometry and Chemometrics
Marine fish oils (MFOs) have been known for their nutritional compounds, which benefit human health. MFOs contain various lipids which play an...
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Determination of Gasdermin Pores
The gasdermin family represents a type of membrane pore-forming proteins. The gasdermin family is extensively characterized as the executioner of... -
Enhanced selective capture of phosphomonoester lipids enabling highly sensitive detection of sphingosine 1-phosphate
Sphingolipids play crucial roles in cellular membranes, myelin stability, and signalling responses to physiological cues and stress. Among them,...
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Skeletal muscle overexpression of short isoform Sirt3 altered mitochondrial cardiolipin content and fatty acid composition
Cardiolipin (CL) is a phospholipid at the heart of mitochondrial metabolism, which plays a key role in mitochondrial function and bioenergetics....
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In situ metabolite and lipid analysis of GluN2D−/− and wild-type mice after ischemic stroke using MALDI MSI
The N -methyl-D-aspartate (NMDA) receptor is a crucial mediator of pathological glutamate-driven excitotoxicity and subsequent neuronal death in acute...
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Synthesis, characterization, and cytotoxicity of doxorubicin-loaded polycaprolactone nanocapsules as controlled anti-hepatocellular carcinoma drug release system
BackgroundFree doxorubicin (Dox) is used as a chemotherapeutic agent against hepatocellular carcinoma (HCC), but it results in cardiotoxicty as a...
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Conformation and molecular dynamics simulation of the interaction between cytochrome c and DNA
Cytochrome c (Cyt c) is a key molecule involved in mitochondria-mediated apoptosis. Cyt c is released into the cytoplasm to bind to apoptotic enzyme...
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Effect of N-Acetylcysteine on Cu2+(Fe2+)/H2O2-Mediated Free-Radical Fragmentation of Glycerophosphate in the Presence of Biologically Active Compounds
AbstractThe effect of N -acetylcysteine on homolytic fragmentation of β-glycerophosphate with cleavage of the phosphoester bond has been studied. It...
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Interaction of Chitosan with Anionic Liquid Liposomes: Reversibility of Structural Rearrangements in Lipid Bilayer
AbstractReversibility of structural rearrangements in a liquid liposomal membrane upon electrostatic adsorption/desorption of the cationic polymer...