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Biological properties of caffeine, (+)-catechin, and theobromine: an in silico study
We analyzed here the in silico biological activities of caffeine, (+)-catechin, and theobromine. For this, the PubChem database of the NIH (National...
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A new anticancer derivative of the natural alkaloid, theobromine, as an EGFR inhibitor and apoptosis inducer
The epidermal growth factor receptor (EGFR) plays a key role in the pathogenesis of cancers of different types. It has been shown that EGFR and...
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Bioactive capacity of peanuts with different coat colors
The present work aimed to evaluate three varieties of peanut ( Arachis hypogaea L.) regarding the content of anthocyanins and total phenolics,...
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Theobromine alleviates diet-induced obesity in mice via phosphodiesterase-4 inhibition
PurposeModern science has given much attention to the treatment of obesity by activating brown adipose tissue (BAT) and browning of white adipose...
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Effects of enzymatic and ultrasonic-assisted extraction of bioactive compounds from cocoa bean shells
This study investigated the assistance of ultrasound and Viscozyme L in the extraction of alkaloid and phenolic compounds from cocoa bean ( Theobroma...
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Chocolate: Food for Mood
Chocolate, revered as the “food of the gods,” has a storied history dating back to the Aztecs, who used it for various purposes, including enhancing...
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Use of Design of Experiments to Optimize the Chromatographic Separation and Ultrasound-Assisted Extraction for Simultaneous Determination of Methylxanthines and Flavonoids in Guarana
In this work, Design of Experiments and the Derringer’s desirability function were used to optimize the chromatographic conditions and an...
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Effect of gamma irradiation on the nutritional composition, phenolic compounds and fatty acids profiles in raw cocoa (Theobroma cacao L.) beans
The γ-irradiation effects on nutritional composition, phenolic compounds and fatty acids profile of cocoa beans were investigated. Raw cocoa bean...
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Target Metabolome and Transcriptome Analysis Reveal Molecular Mechanism Associated with Changes of Tea Quality at Different Development Stages
This study aimed to explore the molecular mechanisms underlying the differential quality of tea made from leaves at different development stages....
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Study of thermally induced interactions between theobromine and various sweeteners
In the past few decades, theobromine has been discovered to play an important role in dental caries prevention being used in different toothpastes...
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Influence of geographical origin in the physical and bioactive parameters of single origin dark chocolate
Dark chocolate presents exclusive characteristics that make it a food product with worldwide consumption and also as an ingredient in several food...
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Determining the Authenticity of Cocoa Solid in Chocolates Using Chemical Markers, Antioxidant Activity, and Multivariate Analysis
The objective was to determine the cocoa solids in chocolates using the content of bioactive compounds and their antioxidant capacity combined with...
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Reaction of 1-Allyl(methallyl)theobromine with Halogens
The reactions of bromine and iodine with 1-allyltheobromine and 1-methallyltheobromine were studied. Depending on the nature of the halogen and the...
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Multishell Au@Ag@SiO2 nanorods embedded into a molecularly imprinted polymer as electrochemical sensing platform for quantification of theobromine
A highly uniform and monodisperse silica-encapsulated Au@Ag multilayered core-shell nanorods (~ 80 nm in length) has been prepared with excellent...
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Thermal behavior of different cocoa powder varieties and their physicochemical, phytochemical and microbiological characteristics
Four cocoa powder varieties processed in different European countries (Germany, Poland, Romania and Bulgaria) were subjected to physicochemical,...
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Theobromine, a Methylxanthine in Cocoa Bean, Stimulates Thermogenesis by Inducing White Fat Browning and Activating Brown Adipocytes
Natural medicinal compounds to treat obesity have recently attracted a great deal of attention because of the serious side effects of synthetic...
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Supercritical fluid chromatography coupled to high-resolution tandem mass spectrometry: an innovative one-run method for the comprehensive assessment of chocolate quality and authenticity
To assess chocolate quality and authenticity comprehensively, a combination of various analytical procedures is involved, thereby making the process...
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Poly(vinyldiaminotriazine) nanoparticle adsorption of small drug molecules in aqueous phase and the role of synergistic interaction between hydrogen bonding and hydrophobic affinity
Poly(vinyldiaminotriazine) nanoparticles adsorbed 5-fluorouracil, thymine, theobromine, and xanthine in aqueous phase. Each drug molecule formed...
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Improving the Composition and Bioactivity of Cocoa (Theobroma cacao L.) Bean Shell Extract by Choline Chloride-Lactic Acid Natural Deep Eutectic Solvent Extraction Assisted by Pulsed Electric Field Pre-Treatment
An environmentally friendly method for the release of cocoa bean shell (CBS) extracts is proposed in this paper. This work aims to investigate the...
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Xanthine and Methyl Xanthine Molecules in Reactions with Low-Energy Electrons
AbstractIntense signals of [M–H] – ions have been detected in the low-energy region of the resonance electron capture mass spectra of xanthine and...
