Search
Search Results
-
Hyperbaric Oxygen Upregulates Mst1 to Activate Keap1/Nrf2/HO-1 Pathway Resisting Oxidative Stress in a Rat Model of Acute Myocardial Infarction
This study aimed to investigate the protective effects and mechanisms of hyperbaric oxygen (HBO) preconditioning in a rat model of acute myocardial...
-
Evaluation of enhancing effect of soybean oil on polymalic acid production by Aureobasidium pullulans HA-4D
Polymalic acid (PMA) is a water-soluble polyester produced by Aureobasidium pullulans . In this study, the physiological response of A. pullulans ...
-
Metabolic Engineering Design Strategies for Increasing Carbon Fluxes Relevant for Biosynthesis in Cyanobacteria
Cyanobacteria are promising microbial cell factories for the direct production of biochemicals and biofuels from CO2. Through genetic and metabolic...
-
Strain engineering and bioprocessing strategies for biobased production of porphobilinogen in Escherichia coli
Strain engineering and bioprocessing strategies were applied for biobased production of porphobilinogen (PBG) using Escherichia coli as the cell...
-
Unveiling the underlying molecular mechanisms of high lutein production efficiency in Chlorella sorokiniana FZU60 under a mixotrophy/photoautotrophy two-stage strategy by transcriptomic, physiological, and biochemical analyses
BackgroundChlorella sorokiniana FZU60 is a promising lutein producing microalga. A mixotrophy/photoautotrophy two-stage strategy can achieve high...
-
Microbial Production of Dicarboxylates: Succinic Acid, Malic Acid, and Itaconic Acid
To establish a bio-based economy, suitable biomass-derived platform chemicals have to be identified, which can be an alternative for their...
-
Metabolic Flux Analysis Based on 13C-Labeling Experiments and Integration of the Information with Gene and Protein Expression Patterns
The recent progress on metabolic systems engineering was reviewed, in particular focusing on the metabolic flux analysis (MFA) based on the...
-
Stress Induced by Recombinant Protein Production in Escherichia coli
Strong production of recombinant proteins interferes with cellular processes in many ways. Drainage of precursors and energy urges the cell to...
-
Enhanced Production of 5-aminolevulinic Acid via Flux Redistribution of TCA Cycle toward l-Glutamate in Corynebacterium glutamicum
5-Aminolevulinic acid (ALA), a valuable nonproteinogenic amino acid, has received increasing attention in various fields including medicine,...
-
Control of Fluxes Towards Antibiotics and the Role of Primary Metabolism in Production of Antibiotics
Yield improvements in antibiotic-producing strains have classically been obtained through random mutagenesis and screening. An attractive alternative...
-
The Metabolism of Respiring Carbon Sources by Dekkera bruxellensis and Its Relation with the Production of Acetate
Dekkera bruxellensis has been studied for several aspects of its metabolism over the past years, which has expanded our comprehension on its...
-
From formic acid to single-cell protein: genome-scale revealing the metabolic network of Paracoccus communis MA5
With the increase in population growth and environmental pollution, the daily protein supply is facing great challenges. Single-cell protein (SCP)...
-
Propionate production by Bacteroidia gut bacteria and its dependence on substrate concentrations differs among species
BackgroundPropionate is a food preservative and platform chemical, but no biological process competes with current petrochemical production routes...
-
Metabolic engineering of Synechocystis sp. PCC 6803 for the improved production of phenylpropanoids
BackgroundPhenylpropanoids are a large group of plant secondary metabolites with various biological functions, derived from aromatic amino acids....
-
Recent advances in bio-based production of top platform chemical, succinic acid: an alternative to conventional chemistry
Succinic acid (SA) is one of the top platform chemicals with huge applications in diverse sectors. The presence of two carboxylic acid groups on...
-
Systems metabolic engineering of Escherichia coli for hyper-production of 5‑aminolevulinic acid
Background5-Aminolevulinic acid (5-ALA) is a promising biostimulant, feed nutrient, and photodynamic drug with wide applications in modern...
-
Construction and modular implementation of the THETA cycle for synthetic CO2 fixation
Synthetic biology offers the opportunity to build solutions for improved capture and conversion of carbon dioxide (CO 2 ) that outcompete those evolved...
-
High throughput 13C-metabolic flux analysis of 3-hydroxypropionic acid producing Pichia pastoris reveals limited availability of acetyl-CoA and ATP due to tight control of the glycolytic flux
BackgroundProduction of 3-hydroxypropionic acid (3-HP) through the malonyl-CoA pathway has yielded promising results in Pichia pastoris ( Komagataella...
-
Biomining Microorganisms: Diversity and Modus Operandi
Consortia of biomining microorganisms catalyze metal sulfide dissolution for extraction and recovery of metals such as gold and copper by...
-
Rational and evolutionary engineering of Saccharomyces cerevisiae for production of dicarboxylic acids from lignocellulosic biomass and exploring genetic mechanisms of the yeast tolerance to the biomass hydrolysate
BackgroundLignosulfonates are significant wood chemicals with a $700 million market, produced by sulfite pul** of wood. During the pul** process,...
