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Scaffold Generator: a Java library implementing molecular scaffold functionalities in the Chemistry Development Kit (CDK)
The concept of molecular scaffolds as defining core structures of organic molecules is utilised in many areas of chemistry and cheminformatics, e.g....
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Selective Laser Sintering PLA/Mg Composite Scaffold with Promoted Degradation and Enhanced Mechanical
Polylactic acid (PLA) is widely used in the treatment of bone defects due to its good properties, but the problem of its slow degradation rate needs...
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Scaffold-based three-dimensional cell model of pancreatic cancer is more suitable than scaffold-free three-dimensional cell model of pancreatic cancer for drug discovery
Pancreatic cancer is one of the deadliest malignancies. Three-dimensional (3D) pancreatic cancer cell models for drug screening have been established...
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Electrospun fibrillary scaffold for electrochemical cell biomarkers detection
A novel scaffold for in situ electrochemical detection of cell biomarkers was developed using electrospun nanofibers and commercial adhesive...
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Polydopamine‐based surface functionalization of watermelon rind as a 3D nanofibrous cellulose scaffold for osteogenesis
In this study, we investigated the osteogenic potential of a low cost, sustainable cellulosic scaffold made from decellularized water-melon rind...
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Aryl sulfoxide scaffold useful as herbicide
The escalating demand for effective and sustainable weed management strategies, driven by urbanization expansion, is a critical challenge. Herbicides...
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Cellulose nanofibril/polylysine-based 3D composite antibacterial scaffold for wound healing applications
Bacterial infections are the major inhibitory factors for natural wound healing. 3D bioprinted nanocellulose-based composite scaffold with a...
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Hydroxyapatite Gradient Poly (Vinyl Alcohol)/Bacteria Cellulose Bone Scaffold via Buoyancy-Driven Gradient Method
The repair of bone defects necessitates the establishment of sophisticated gradients. However, most strategies for gradient casting require...
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QSAR Studies on Thiazolidines: A Biologically Privileged Scaffold
A large number of drugs and biologically relevant molecules contain heterocyclic systems. Often the presence of hetero atoms or grou**s imparts...
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Development of Nurr1 agonists from amodiaquine by scaffold hop** and fragment growing
The neuroprotective transcription factor nuclear receptor-related 1 (Nurr1) has shown great promise as a therapeutic target in Parkinson’s and...
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Novel polypeptide composite fibrous scaffold with internal chemical boundary
Cell migration determines the complete development of mammalian tissue and other pathological phenomena. To investigate the effect of chemical...
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Highly Porous and Rigid, Full-thickness Human Skin Model from the Slime-webbed Fiber Scaffold
Collagen is the most prevalent scaffold material for in vitro skin models. The major limitation of collagen scaffold is its mechanical weakness,...
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Biomimetic bone-periosteum scaffold for spatiotemporal regulated innervated bone regeneration and therapy of osteosarcoma
The complexity of repairing large segment defects and eradicating residual tumor cell puts the osteosarcoma clinical management challenging. Current...
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Biomimetic ECM-Based Hybrid Scaffold for Cartilage Tissue Engineering Applications
Conventional methods have failed to show the ability of articular cartilage to completely restore. Decellularized extracellular matrix has achieved...
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Research progress of multi-enzyme complexes based on the design of scaffold protein
Multi-enzyme complexes designed based on scaffold proteins are a current topic in molecular enzyme engineering. They have been gradually applied to...
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Synthesis of electrospun PVA/chitosan nanofibrous scaffold impregnated with CuO nanoparticles for wound healing
In the current study, cupric oxide nanoparticles (CuO NPs) are chemically synthesized and blended with polyvinyl alcohol and chitosan (PVA-CS)...
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Baghdadite reinforced polycaprolactone scaffold for bone tissue engineering
In this work, baghdadite (Bag) bioceramic powder was synthesized using the mechanical activation method and was characterized using X-ray diffraction...
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Calcium phosphate coating enhances osteointegration of melt electrowritten scaffold by regulating macrophage polarization
The osteoimmune microenvironment induced by implants plays a significant role in bone regeneration. It is essential to efficiently and timely switch...
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ScaffoldGVAE: scaffold generation and hop** of drug molecules via a variational autoencoder based on multi-view graph neural networks
In recent years, drug design has been revolutionized by the application of deep learning techniques, and molecule generation is a crucial aspect of...
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Highly Porous 3D Printed Scaffold Incorporated with Graphene Oxide-Merwinite and Coated with IGF1 Loaded Nanofibers for Calvarial Defect Repair
Critical-sized calvarial bone defects remain a significant challenge in orthopedic surgery, especially for irregularly shaped bones. Herein, we...
