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Fabrication and Osteoblastic Adhesion Behavior of Regenerated Silk Fibroin/PLLA Nanofibrous Scaffold by Double Syringe Electrospinning
In this work, regenerated silk fibroin (SF)/poly-L-lactic acid (PLLA) composite electrospun fibers were successfully prepared by electrospinning...
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Nanotopographical cues for regulation of macrophages and osteoclasts: emerging opportunities for osseointegration
Nanotopographical cues of bone implant surface has direct influences on various cell types during the establishment of osseointegration, a...
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Hydroxycarbonate apatite formation, cytotoxicity, and antibacterial properties of rubidium-doped mesoporous bioactive glass nanoparticles
Rubidium (Rb) has been shown to impact biological activity. This work synthesized Rb-doped mesoporous bioactive glass nanoparticles (MBGNs) based on...
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A simple and inexpensive method for evaluation of in vitro cell adhesion on screws
Only a limited number of techniques are available for assessing the effect of different coating materials on cell adherence to screws. In this study,...
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Bone tissue engineering for osteointegration: Where are we now?
Bone fracture healing is a challenging process, due to insufficient and slow tissue repair. Sufferers from bone fractures struggle with one-third of...
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Bilayered porous composite scaffolds for enhanced treatment of bone cancer through chemo-photothermal combination therapy
The combination of therapeutic materials and biocompatible scaffolds to create multifunctional scaffolds with therapeutic and restorative functions...
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Evaluation of In Vitro Bioactivity, Cytotoxicity, and Drug Release Behavior of Er2O3 and Tb2O3-Containing Bioactive Glass Particles and Nanofibers
Silicate-based bioactive glasses doped with Er 3+ and Tb 3+ ions (1, 3, and 5 wt%) were synthesized in the form of powders and nanofibers using sol–gel...
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Protein-Based Hybrid Scaffolds: Application in Bone Tissue Engineering
Proteins are one of the most prevalent components of the extracellular matrix, which are used in bone tissue engineering for construction of...
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In Vitro Fabrication and Biocompatibility Assay of a Biomimetic Osteoblastic Niche
A novel HAp-CS/Gel biomimetic osteoblastic niche was fabricated by freeze-drying, and its mechanical strength and biocompatibility were...
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Application of Bioactive Compounds and Biomaterials in Promoting Cell Differentiation, Proliferation, and Tissue Regeneration
Cells, mainly stem cells, possess immense potential in regenerative medicine. Stem cells (SCs) can also play a crucial role in treating diseases due...
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Fabrication and Characterization of Gelatin/Calcium Phosphate Electrospun Composite Scaffold for Bone Tissue Engineering
Although bone tissue has a unique healing capacity that does not induce scar tissue formation, complex fractures can lead to delayed healing. Tissue...
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Modifying Porous Bacterial Cellulose with Chondroitin Sulfate/Gelatin for Improved Biocompatibility
Lacking large pores and insufficient bioactivity are two critical disadvantages of bacterial cellulose (BC). In this study, a new type of coating,...
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Physicochemical and microstructural properties of porous Zn-doped hydroxyapatite ceramics: cell behavior on their surfaces
Porous hydroxyapatite (HAp) ceramics with macropores of more than 200 μm were fabricated via our new method comprising chemical synthesis and heat...
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Chitosan-based Hydrogels in Drug Delivery
Hydrogels are three-dimensional cross-linked hydrophilic polymers that are able to absorb large quantities of water and swell. They have various...
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Organ-Derived Extracellular Matrix (ECM) Hydrogels: Versatile Systems to Investigate the Impact of Biomechanics and Biochemistry on Cells in Disease Pathology
The extracellular matrix (ECM) provides instructive and constructive support to cells in all organs. The ECM’s composition and structure are...
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Biomineralized tetramethylpyrazine-loaded PCL/gelatin nanofibrous membrane promotes vascularization and bone regeneration of rat cranium defects
Conventional electrospinning produces nanofibers with smooth surfaces that limit biomineralization ability. To overcome this disadvantage, we...
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Effect of piezoelectricity of nanocomposite electrospun scaffold on cell behavior in bone tissue engineering
Piezoelectric materials can generate electrical activity under deformation. Various types of these materials have been used for tissue regeneration,...
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Materialistic characterization, thermal properties, and cytocompatibility investigations on acrylic acid-functionalized nSiO2-reinforced PEEK polymeric nanocomposite
Polyether ether ketone (PEEK) is a biocompatible alternative to metallic biomaterials because of its unique properties and biocompatibility. Its...
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Hydrogel Biomaterial in Bone Tissue Engineering
The repair of critical-sized bone defect caused by trauma or disease poses a remarkable clinical challenge. Even though conventional methods such as...
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Collagen and Gelatin from Fish Processing By-Products for Biomedical Applications
Fish discards that otherwise constitute a threat to environmental health are also a reservoir of bioactive molecules, peptides, and polymers that...