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Homogeneous multi-payload antibody–drug conjugates
Many systemic cancer chemotherapies comprise a combination of drugs, yet all clinically used antibody–drug conjugates (ADCs) contain a single-drug...
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Progress in graphene-based electrochemical sensors for antibiotic residue detection
The presence of antibiotic residues in food products due to the extensive use of antibiotics in animal farming poses significant risks to human...
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Transforming Agri-crop Residue Biomass for Value Addition: An Innovative Strategy Toward Resilient Circular Economy
Cereal straws, such as barley straw, wheat straw, maize, corncobs, corn stove, miscanthus, rice straw, sugarcane bagasse, manure, seaweeds and algae,...
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Targeting multi-drug-resistant Acinetobacter baumannii: a structure-based approach to identify the promising lead candidates against glutamate racemase
ContextAcinetobacter baumannii , one of the critical ESKAPE pathogens, is a highly resilient, multi-drug-resistant, Gramnegative, rod-shaped, highly...
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Transforming Agri-Crop Residue Biomass for Value Addition: An Innovative Strategy Toward Resilient Circular Economy
Cereal straws, such as barley straw, wheat straw, maize, corncobs, corn stove, miscanthus, rice straw, sugarcane bagasse, manure, seaweeds and algae,...
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Optimization of a Multi-Residue Screening Method for the Detection of 71 Antimicrobial Residues in Milk Products: the Case of Labneh
Labneh is a dairy product highly consumed in Lebanon, prepared from straining yogurt. Because there is a lack of surveillance of the antimicrobial...
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A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyethyl)-RNA
Steric exclusion is a key element of enzyme substrate specificity, including in polymerases. Such substrate specificity restricts the enzymatic...
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Advances in Analysis of Contaminants in Foodstuffs on the Basis of Orbitrap Mass Spectrometry: a Review
It is a complex and time-consuming business to monitor potential contaminants in foodstuffs. Due to their complexity, false-positive results often...
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Detection of benzylpenicillin sodium and ampicillin residue based on flower-like silver nanostructures using surface-enhanced Raman spectroscopy
The capability to evaluate antibiotic residues in a sensitive, rapid, and reliable manner, is of great importance. Surface-enhanced Raman...
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Simultaneous determination of sulfonylurea herbicides in tomatoes using the QuEChERS method coupled with HPLC
The simultaneous determination of trace pesticides in complex matrices containing high concentrations of natural pigments remains challenging. In...
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Analysis of 207 residual pesticides in hot pepper powder using LC–MS/MS
This study investigated the determination of 207 pesticides in hot pepper powder and found patterns of pesticide use by production from five regions,...
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Analysis of Food Contaminants, Residues, and Chemical Constituents of Concern
Consumer concerns and government regulations focused on the safety of foods dictate the need for analysis of various food contaminants, residues, and...
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Validation of HPLC-UV Multi-Residue Method for the Simultaneous Determination of Tetracycline, Oxytetracycline, Spiramycin and Neospiramycin in Raw Milk
The use of antimicrobial agents in livestock breeding is inevitable for prophylactic and treatment purposes, in order to maintain health and improve...
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Analysis of thermal decomposition of magnetic nanoparticles synthesized by reverse coprecipitation and partial oxidation of ferrous ions
Magnetite nanoparticles were synthesized by two methods: reverse coprecipitation and partial oxidation of ferrous ions. The particles were...
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Establishment of analysis method for the quantification of residues of halquinol and its metabolites in livestock and fishery products using liquid chromatography–tandem mass spectrometry
In this study, an analysis method was established for the quantification of residues of halquinol and its metabolites in livestock and fishery...
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Analysis of Polysaccharides by Ultracentrifugation. Size, Conformation and Interactions in Solution
The launch of the XL-I analytical ultracentrifuge by Beckman Instruments (Palo Alto, USA) in 1996 and subsequent development of penetrating...
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Domino Dendrimers
Domino dendrimers have recently been developed and introduced as a potential platform for a single triggered multi-prodrug. Surprisingly, three...
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Moisture and Total Solids Analysis
Moisture assays can be one of the most important analyses performed on a food product and yet one of the most difficult from which to obtain accurate...
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Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R
Acquired drug resistance poses a challenge for single-target FGFR inhibitors, leading to the development of dual- or multi-target FGFR inhibitors....
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Amphipathic dendritic poly-peptides carrier to deliver antisense oligonucleotides against multi-drug resistant bacteria in vitro and in vivo
BackgroundOutbreaks of infection due to multidrug-resistant (MDR) bacteria, especially Gram-negative bacteria, have become a global health issue in...
