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A Method to Collect Cerebrospinal Fluid from Mouse Cisterna Magna to Determine Extracellular Tau Levels
Despite being a cytoplasmic protein abundant in neurons, tau is detectable in various extracellular fluids. In addition to being passively released...
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Detection of Glymphatic Outflow of Tau from Brain to Cerebrospinal Fluid in Mice
Glymphatic system denotes a brain-wide pathway that eliminates extracellular solutes from brain. It is driven by the flow of brain interstitial fluid...
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Fluid Mechanics: Applications
In this chapter, we will focus on some selected applications of fluid mechanics. Food processing and manufacturing operations involve handling...
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Elements of Fluid Flow
Most materials encountered in food processes are in the fluid state, i.e. liquid and gaseous. This chapter covers the flow properties of fluids and...
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CFD Simulation of Wet Spouted Fluidized Bed using Two-fluid Model with Variable Restitution Coefficient and Diameter
AbstractGas-solid fluidized bed usually forms wet particle fluidization system due to a small amount of liquid on the particle surface, resulting in...
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Achieving deep intratumoral penetration and multimodal combined therapy for tumor through algal photosynthesis
BackgroundElevated interstitial fluid pressure within tumors, resulting from impaired lymphatic drainage, constitutes a critical barrier to effective...
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Blood-Arachnoid Barrier as a Dynamic Physiological and Pharmacological Interface Between Cerebrospinal Fluid and Blood
The blood-arachnoid barrier (BAB) consists of arachnoid epithelial cells linked by tight junctions, and forms one of the interfaces between blood and...
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Automated and fast online method for simultaneously determining a broad spectrum of per- and polyfluoroalkyl substances in a small volume of cerebrospinal fluid
Per- and polyfluoroalkyl substances (PFASs) are potentially neurotoxic compounds. Levels of PFASs in cerebrospinal fluid (CSF) could directly reflect...
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A numerical study on the effect of static magnetic field on the hemodynamics of magnetic fluid in biological porous media
High interstitial fluid pressure in the tumor is among the most important barriers to drug delivery. The use of the static magnetic field is one of...
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Computational modeling of PET tracer distribution in solid tumors integrating microvasculature
BackgroundWe present computational modeling of positron emission tomography radiotracer uptake with consideration of blood flow and interstitial...
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Insights from molecular simulations on liquid slip over nanostructured surfaces
The current study focuses on non-equilibrium molecular dynamics (NEMD) simulations to investigate the slip properties of water flowing over different...
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Wearing the Lab: Advances and Challenges in Skin-Interfaced Systems for Continuous Biochemical Sensing
Continuous, on-demand, and, most importantly, contextual data regarding individual biomarker concentrations exemplify the holy grail for personalized...
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Anatomy and Physiology of the Blood-Brain Barriers*
This chapter covers the three main barrier layers separating blood and the CNS: the endothelium of the brain vasculature, the epithelium of the...
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A 3D-printed multi-compartment device that enables dynamic PK/PD profiles of antibiotics
Pathogens develop resistance to various drugs while under the selective pressure of antibiotics resulting in the emergence of bacterial strains that...
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Simultaneous glutamine metabolism and PD-L1 inhibition to enhance suppression of triple-negative breast cancer
Blockade of programmed cell death 1 ligand (PD-L1) has been used to treat triple-negative breast cancer (TNBC), and various strategies are under...
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Wearable chemical sensors for biomarker discovery in the omics era
Biomarkers are crucial biological indicators in medical diagnostics and therapy. However, the process of biomarker discovery and validation is...
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Field effect transistor based wearable biosensors for healthcare monitoring
The rapid advancement of wearable biosensors has revolutionized healthcare monitoring by screening in a non-invasive and continuous manner. Among...
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Green Fabrication of Nonenzymatic Glucose Sensor Using Multi-Walled Carbon Nanotubes Decorated with Copper (II) Oxide Nanoparticles for Tear Fluid Analysis
In this report, a green, simple, inexpensive, and effective nonenzymatic electrochemical glucose sensor was fabricated using multi-walled carbon...
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Passive-Flow-Based MPS: Emerging Physiological Flow-Mimetic Platforms for Studying Effects of Flow on Single Tissues and Inter-tissue Interactions
Flow at various scales, such as perfusion flow and interstitial flow, is a critical component of the physiology of living systems. Microphysiological...
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Effect of Silicon Segregation in the Argon Arc Welded Incoloy 20 Superalloy
Incoloy 20 is prone to hot cracking due to micro-segregation of alloying elements. The aim of the work is to investigate the chances of curtailing...