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Non-competitive fluorescence polarization immunoassay for detection of H5 avian influenza virus using a portable analyzer
Nowadays, the diagnosis of viral infections is receiving broad attention. We have developed a non-competitive fluorescence polarization immunoassay...
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A conserved multi-epitope-based vaccine designed by targeting hemagglutinin protein of highly pathogenic avian H5 influenza viruses
The highly pathogenic avian H5N1 influenza viruses have been recognized as a potential pandemic threat to humans, and to the poultry industry since...
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A strip test for the optical determination of influenza virus H3 subtype using gold nanoparticle coated polystyrene latex microspheres
A strip test is described for the optical determination of influenza virus H3 subtype. It utilizes gold nanoparticle (AuNP) coated polystyrene latex...
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Influenza Vaccine: An Engineering Vision from Virological Importance to Production
According to data from the World Health Organization (WHO) every year, millions of people are affected by flu. Flu is a disease caused by influenza...
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Novel pyrazolothienopyridinones as potential GABAA receptor modulators
The synthesis of novel pyrazolothienopyridinone derivatives as potential GABA A receptor modulators was performed and is herein described. A crucial...
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The role of G protein conformation in receptor–G protein selectivity
G protein-coupled receptors (GPCRs) selectively activate at least one of the four families of heterotrimeric G proteins, but the mechanism of...
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Peptide Models of the Cytoplasmic Tail of Influenza A/H1N1 Virus Hemagglutinin Expand Understanding its pH-Dependent Modes of Interaction with Matrix Protein M1
Influenza A virus hemagglutinin (HA) is a major virus antigen. No cryo-electron microscopy or X-ray data can be obtained for the HA intraviral...
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Rapid Subty** and Pathoty** of Avian Influenza Virus using Chip-based RT-PCR
Frequent outbreaks of avian influenza viruses (AIV), which are influenza A viruses, result in heavy economic and national damages. However, current...
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Protocol for Classification Single-Cell PBMC Types from Pathological Samples Using Supervised Machine Learning
Peripheral blood mononuclear cells (PBMC) are mixed subpopulations of blood cells composed of five cell types. PBMC are widely used in the study of...
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Reverse Genetics and Its Usage in the Development of Vaccine Against Poultry Diseases
Vaccines are the most effective and economic way of combating poultry viruses. However, the use of traditional live-attenuated poultry vaccines has...
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Antigenic characterization of influenza and SARS-CoV-2 viruses
Antigenic characterization of emerging and re-emerging viruses is necessary for the prevention of and response to outbreaks, evaluation of infection...
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Vaccine design via antigen reorientation
A major challenge in creating universal influenza vaccines is to focus immune responses away from the immunodominant, variable head region of...
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Tobacco-Based Vaccines, Hopes, and Concerns: A Systematic Review
Emerging infectious diseases have vigorously devastated the global economy and health sector; cost-effective plant-based vaccines (PBV) can be the...
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G-Quadruplex-Based Aptamers in Therapeutic Applications
Nucleic acid aptamers are single or multiple stranded DNA or RNA molecules identified to recognize with high affinity specific targets including...
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G-Quadruplex-Based Aptamers in Therapeutic Applications
Nucleic acid aptamers are single or multiple stranded DNA or RNA molecules identified to recognize with high affinity specific targets including...
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3,5-Dibromophenyl-functionalised imidazolium salts and their corresponding [Au(NHC)2]+ complexes: synthesis, supramolecular chemistry and anti-cancer activity
The synthesis and spectroscopic and structural characterisation of new 3,5-dibromophenyl-functionalised imidazolium salts and their corresponding...
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Quantitative analysis of respiratory viruses based on lab-on-a-chip platform
The quantitative analysis of respiratory viruses is of great importance for rapid diagnosis, precision medicine, and prognosis. Several current...
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Insights into structural and inhibitory mechanisms of low pH-induced conformational change of influenza HA2 protein: a computational approach
Though oseltamivir and zanamivir are the active anti-influenza drugs, the emergence of different strains of influenza A virus with mutations creates...
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Targeted Cancer Therapy: KRAS-Specific Treatments for Pancreatic Cancer
Pancreatic cancer is highly dependent on the activity of the KRAS oncogene, which controls the redox homeostasis and induces metabolic reprogramming....
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Haemagglutinin displayed on the surface of Lactococcus lactis confers broad cross-clade protection against different H5N1 viruses in chickens
BackgroundThe highly pathogenic avian influenza (HPAI) H5N1 virus poses a potential threat to the poultry industry. The currently available avian...
