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Reverse Genetics and Its Usage in the Development of Vaccine Against Poultry Diseases

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Vaccine Design

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2411))

Abstract

Vaccines are the most effective and economic way of combating poultry viruses. However, the use of traditional live-attenuated poultry vaccines has problems such as antigenic differences with the currently circulating strains of viruses and the risk of reversion to virulence. In veterinary medicine, reverse genetics is applied to solve these problems by develo** genotype-matched vaccines, better attenuated and effective live vaccines, broad-spectrum vaccine vectors, bivalent vaccines, and genetically tagged recombinant vaccines that facilitate the serological differentiation of vaccinated animals from infected animals. In this chapter, we discuss reverse genetics as a tool for the development of recombinant vaccines against economically devastating poultry viruses.

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Authors and Affiliations

  1. Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India

    Barnali Nath, Sudhir Morla & Sachin Kumar

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  1. Barnali Nath
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  2. Sudhir Morla
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  3. Sachin Kumar
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Correspondence to Sachin Kumar .

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  1. Lankenau Institute for Medical Research, Wynnewood, PA, USA

    Sunil Thomas

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Nath, B., Morla, S., Kumar, S. (2022). Reverse Genetics and Its Usage in the Development of Vaccine Against Poultry Diseases. In: Thomas, S. (eds) Vaccine Design. Methods in Molecular Biology, vol 2411. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1888-2_4

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  • DOI: https://doi.org/10.1007/978-1-0716-1888-2_4

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1887-5

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