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Digital PCR using a simple PDMS microfluidic chip and standard laboratory equipment
Digital PCR (dPCR) enables sensitive and precise quantification of template nucleic acid without calibration. However, dPCR is not yet in widespread...
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Towards a microfluidic H295R steroidogenesis assay—biocompatibility study and steroid detection on a thiol-ene-based chip
The development of cell-based microfluidic assays offers exciting new opportunities in toxicity testing, allowing for integration of new...
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Immunogenicity Monitoring Cell Chip Incorporating Finger-Actuated Microfluidic and Colorimetric Paper-Based Analytical Functions
Recently, with the development of microfluidic chips, attempts to integrate cell culture and biomedical material testing functions into a single chip...
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Revolutionizing the female reproductive system research using microfluidic chip platform
Comprehensively understanding the female reproductive system is crucial for safeguarding fertility and preventing diseases concerning women's health....
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Microfluidic chip immunoassay based on rolling circle amplification and G-quadruplex/Thioflavin T for multiplex detection of CTX I
A label-free immunoassay based on rolling circle amplification (RCA) and G-quadruplex/Thioflavin T (G4/ThT) is proposed to realize the sensitive...
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Nickel-Doped Microfluidic Chip for Rapid and Efficient Immunomagnetic Separation and Detection of Breast Cancer Cell-Derived Exosomes
Breast cancer cell-derived exosomes have high potential as biomarkers for continuous biopsies and longitudinal monitoring in breast cancer. However,...
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PMMA/paper hybrid microfluidic chip for simultaneous determination of arginine and valine in human plasma
The simultaneous determination is reported of arginine (Arg) and valine (Val) amino acids in plasma using flower-shaped μPADs and PMMA/paper hybrid...
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A microfluidic chip using Au@SiO2 array–based highly SERS-active substrates for ultrasensitive detection of dual cervical cancer–related biomarkers
In this work, a microfluidic chip using Au@SiO 2 array–based highly active SERS substrates was developed for quantitative detection of squamous cell...
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Microfluidic Cartridge for Bead-Based Affinity Assays
Within the vast field of medical biotechnology, the biopharmaceutical industry is particularly fast-growing and highly competitive, so reducing time...
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A tri-fluid tortuous microfluidic chip for green synthesis of nanoparticles and inactivation of a model gram-negative bacteria: Intracellular components evaluation
The development of green synthesis route using plant extract as a simple, cost-effective, and eco-friendly method for the synthesis of nanoparticles...
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Advances in microfluidic technology for sperm screening and in vitro fertilization
About 18% of reproductive-age adults worldwide are affected by infertility. In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI)...
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Lab-on-chip technologies for space research — current trends and prospects
The in-depth analysis concerning application of microfluidic instruments for space biology research is presented. The article focuses on recently...
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A high-throughput microfluidic diploid yeast long-term culturing (DYLC) chip capable of bud reorientation and concerted daughter dissection for replicative lifespan determination
BackgroundBudding yeast, Saccharomyces cerevisiae , has been extensively favored as a model organism in aging and age-related studies, thanks to...
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Nanosensor-Enabled Microfluidic Biosensors for the Detection of Pathogenic Bacteria
The standard techniques to detect pathogenic bacteria include culture, enzyme-linked immunosorbent assay (ELISA), and polymerase chain reaction...
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A tempo-spatial controllable microfluidic shear-stress generator for in-vitro mimicking of the thrombus
Pathological conditions linked to shear stress have been identified in hematological diseases, cardiovascular diseases, and cancer. These conditions...
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Advances in Technical Assessment of Spiral Inertial Microfluidic Devices Toward Bioparticle Separation and Profiling: A Critical Review
Separation of micro- and nano-sized bioparticles is essential for efficient diagnostics, chemical and biological analyses, drug development, food and...
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Multi-layered Microfluidic Drug Screening Platform Enabling Simultaneous Generation of Linear and Logarithmic Concentration Gradients
Since many microfluidic devices have limited drug dose order of gradients and incorporate 2D cell culture, we here present a multi-layered platform...
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Mass spectrometry coupling of chip-based supercritical fluid chromatography enabled by make-up flow-assisted backpressure regulation
This work introduces a novel microfluidic backpressure pressure control developed for chip-based supercritical fluid chromatography (chipSFC). The...
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A microfluidic platform for simulating stem cell migration using in vivo-like gradients of stem cell mobilizer
Stem cell mobilization by cytokines and peptide drugs contributes to wound healing in injured tissues. Owing to the short half-life of cytokines and...