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Chiral phosphoric acid-catalyzed enantioselective phosphinylation of 3,4-dihydroisoquinolines with diarylphosphine oxides
Chiral phosphorous-containing compounds are playing a more and more significant role in several different research fields. Here, we show a chiral...
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Recent progress on asymmetric multicomponent reactions via chiral phosphoric acid catalysis
Multicomponent reactions (MCRs) are very important to provide enantiomerically enriched compounds with high structural diversity and complexity....
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Modular and diverse synthesis of amino acids via asymmetric decarboxylative protonation of aminomalonic acids
Stereoselective protonation is a challenge in asymmetric catalysis. The small size and high rate of transfer of protons mean that face-selective...
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Chiral polyanilines: synthesis, chirality influencing parameters and applications
Recently supramolecular chirality has received increasing interest due to its potential applications in enantioselective sensors and chromatographic...
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Asymmetric dearomatization catalysed by chiral Brønsted acids via activation of ynamides
Chiral Brønsted acid-catalysed asymmetric synthesis has received tremendous interest over the past decades, and numerous efficient synthetic methods...
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MATEO: intermolecular α-amidoalkylation theoretical enantioselectivity optimization. Online tool for selection and design of chiral catalysts and products
The enantioselective Brønsted acid-catalyzed α-amidoalkylation reaction is a useful procedure is for the production of new drugs and natural...
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An unprecedented synthesis of axially chiral biaryls by rearrangement and aromatization of carbocations with central-to-axial conversion of chirality
The central-to-axial chirality conversion represents a fascinating class of chemical processes consisting of the destruction of stereogenic centers...
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Recent advances in the construction of axially chiral arylpyrroles
Catalytic enantioselective preparation of axially chiral molecules has gained considerable interest over the past decades, due to their numerous...
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Discovery and synthesis of atropisomerically chiral acyl-substituted stable vinyl sulfoxonium ylides
Atropisomerism is a type of conformational chirality that plays a critical role in various fields of chemistry, including synthetic, medicinal and...
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Nucleic Acids in Green Chemistry
Deoxyribonucleic acid (DNA) is one of the most important biopolymers for all living organisms; DNA exhibits characteristic physical properties...
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Synthesis, Alpha-Glucosidase Inhibition and Antibacterial Activities of the New Chiral (R)-3,3′-Disubstituted BINOL-Phosphates
AbstractA new class of 3,3′-disubstituted chiral ( R )-BINOL-derived phosphoric acid derivatives has been prepared. The synthetic method has been...
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Discovery, characterization and mechanism of a Microbacterium esterase for key d-biotin chiral intermediate synthesis
Esterases are crucial biocatalysts in chiral compound synthesis. Herein, a novel esterase EstSIT01 belonging to family V was identified from Microbacte...
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Synthesis of Chiral Macrocycles Based on Bispidine
AbstractFirst representatives of chiral ferrocenophanes have been synthesized from bispidines. Their structure in solution has been found to be...
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Cobalt(III) hydride HAT mediated enantioselective intramolecular hydroamination access to chiral pyrrolidines
Enantioenriched pyrrolidines and derivatives are ubiquitous substructures in compounds of importance to medicinal and biological chemistry. Herein,...
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Enantioselective synthesis of amino acids from ammonia
Metal-catalysed reactions involving ammonia gas are plagued by ammonia’s strong Lewis basicity, which leads to poor chemoselectivity and...
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One-pot remote desymmetrization/peterson-olefination for the construction of silicon-stereogenic silyl ethers
Chiral silyl ethers and silanols are important synthetic intermediates and bioactive compounds. In this work, we developed a one-pot remote...
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Recent Progress in Asymmetric Relay Catalysis of Metal Complex with Chiral Phosphoric Acid
Asymmetric metal/organo relay catalysis, utilizing a metal complex and a chiral organocatalyst in a one-pot cascade reaction, is aimed to...
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Chiral Brønsted acid-catalyzed asymmetric intermolecular [4 + 2] annulation of ynamides with para-quinone methides
Catalytic asymmetric transformations of ynamides have attracted considerable attention in recent years. However, most of them were limited to...
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Applications of Capillary Electrophoresis-Mass Spectrometry to Chiral Analysis
Capillary electrophoresis (CE) is a technique that has already proven its importance in the separation of enantiomers. The combination of CE with...
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Atropoenantioselective synthesis of heterobiaryl N-oxides via dynamic kinetic resolution
A highly efficient enantioselective construction of heterobiaryl N -oxides was developed. A series of axially chiral heterobiaryl N -oxides were...
