Search
Search Results
-
On the Verge of Impossibility: Accounting for Variability Arising from Permutations of Comorbidities that Affect the Fate of Drugs in the Human Body
Contending with variability in drug exposure and effect in disease populations requires patient characterization for changes in drug metabolism and...
-
Use of Reductive Amination to Produce Capsular Polysaccharide-Based Glycoconjugates
Reductive amination is a relatively simple and convenient strategy for coupling purified polysaccharides to carrier proteins. Following their...
-
Multimodal Control of Bacterial Gene Expression by Red and Blue Light
By applying sensory photoreceptors, optogenetics realizes the light-dependent control of cellular events and state. Given reversibility,...
-
An optimized bioluminescent substrate for non-invasive imaging in the brain
Bioluminescence imaging (BLI) allows non-invasive visualization of cells and biochemical events in vivo and thus has become an indispensable...
-
Combination of MALDI-MSI and cassette dosing for evaluation of drug distribution in human skin explant
Study of skin penetration and distribution of the drug compounds in the skin is a major challenge in the development of topical drug products for...
-
Expression, Purification, and Biological Evaluation of XTEN-GCSF in a Neutropenic Rat Model
Granulocyte colony-stimulating factor (GCSF) stimulates the proliferation of neutrophils but it has low serum half-life. Therefore, the present study...
-
Monitoring Multidrug Resistance P-Glycoprotein Drug Transport Activity with Single-Photon Emission Computed Tomography and Positron Emission Tomography Radiopharmaceuticals
Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (Pgp) is one of the best characterized transporter-mediated barriers to...
-
The Blood-Brain Barrier in Stroke and Trauma and How to Enhance Drug Delivery
Ischemic or hemorrhagic stroke and traumatic brain injury (TBI) cause marked changes in blood-brain barrier (BBB) function. Such changes increase...
-
Engineering siRNA therapeutics: challenges and strategies
Small interfering RNA (siRNA) is a potential method of gene silencing to target specific genes. Although the U.S. Food and Drug Administration (FDA)...
-
Nanoemulsions-Based Systems for Breast Cancer Treatment
Breast cancer is the most prevalent malignancy in this group of patients and is the second most deadly disease in women after lung cancer. Nowadays,...
-
Drug Discovery Methods for Studying Brain Drug Delivery and Distribution
Methods used in drug discovery laboratories for assessing the delivery of small molecules to the brain have changed significantly in recent years....
-
Lab-on-a-Chip Systems for Biomedical Analysis
Over the last few decades, significant progress has been made in the field of chemical and biochemical analysis, especially for clinical...
-
Lab-on-a-Chip Systems for Biomedical Analysis
Over the last few decades, significant progress has been made in the field of chemical and biochemical analysis, especially for clinical...
-
Capillary Electrophoresis–Mass Spectrometry (CE-MS) by Sheath–Flow Nanospray Interface and Its Use in Biopharmaceutical Applications
Both capillary electrophoresis (CE) and mass spectrometry (MS) technologies are powerful analytical tools that have been used extensively in the...
-
Manufacturing the Biopharmaceutical Drug Product
Manufacture of the finished drug product is the last process step (from starting materials to drug substance and now to drug product) for the...
-
Activation of human STING by a molecular glue-like compound
Stimulator of interferon genes (STING) is a dimeric transmembrane adapter protein that plays a key role in the human innate immune response to...
-
Energy-Efficient One-Step Synthesis of a [Re,W]/α-Al2O3 Ceramic Catalytic Converter for the Dehydrogenation of Ethylbenzene to Styrene
AbstractA porous ceramic catalytic converter was synthesized on the basis of a coarse α-Al 2 O 3 powder filler using ultrafine strengthening binders of...
-
Genome-wide screen identifies new set of genes for improved heterologous laccase expression in Saccharomyces cerevisiae
The yeast Saccharomyces cerevisiae is widely used as a host cell for recombinant protein production due to its fast growth, cost-effective culturing,...
-
Drug Delivery to the Brain: Physiological Concepts, Methodologies, and Approaches
An important property in any central nervous system (CNS) drug is the ability to cross into the brain and reach therapeutic concentrations at safe...
-
Chemoresistance Mechanisms in Non-Small Cell Lung Cancer—Opportunities for Drug Repurposing
Globally, lung cancer contributes significantly to the public health burden–associated mortality. As this form of cancer is insidious in nature,...
